Chemometrically assissted optimization and validation of RP-HPLC method for the analysis of itraconazole and its impurities

Acta Pharmaceutica

Volumn 63, Issue 2, 2013, Pages 159-173

  Kasagić, Irena ^a   Malenović, Andelija D S ^b   Jovanović, Marko ^b   Rakić, Tijana ^b   Stojanović, Biljana Jančić ^b   Ivanović, Darko ^b  

^a UNIVERSITY OF BANJA LUKA   (Bosnia and Herzegovina)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Box Behnken design; fractional factorial design; high performance liquid chromatography; itraconazole; itraconazole impurities

Indexed keywords

ACETONITRILE; HYDROXYITRACONAZOLE; ITRACONAZOLE; OMICRAL; PHOSPHORIC ACID; UNCLASSIFIED DRUG; WATER;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL STRUCTURE; CHEMOMETRICS; COLUMN CHROMATOGRAPHY; DRUG CAPSULE; DRUG DETERMINATION; DRUG DOSAGE FORM; DRUG IMPURITY; FACTORIAL DESIGN; FLOW RATE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; PARTICLE SIZE; PH; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TEMPERATURE; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 84880796841     PISSN: 13300075     EISSN: 18469558     Source Type: Journal    
DOI: 10.2478/acph-2013-0015     Document Type: Article

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