Drug impurity profiling: Method optimization on dissimilar chromatographic systems. Part I: pH optimization of the aqueous phase

Analytica Chimica Acta

Volumn 656, Issue 1-2, 2009, Pages 85-92

  Dumarey, M ^a   Sneyers, R ^b   Janssens, W ^b   Somers, I ^b   Vander Heyden, Y ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Dissimilar chromatographic systems; High Performance Liquid Chromatography (HPLC); Impurity profiling; pH optimization

Indexed keywords

AQUEOUS PHASE; BEST STRATEGY; CHROMATOGRAPHIC SYSTEMS; IMPURITY PROFILE; IMPURITY PROFILING; INTERMEDIATE CONDITIONS; LINEAR MODEL; MAXIMAL INFORMATION; METHOD DEVELOPMENT; MOBILE PHASE; ORGANIC MODIFIER; PH OPTIMIZATION; PH VALUE; RETENTION TIME; SECOND DEGREE POLYNOMIALS; STATIONARY PHASIS; STRAIGHT LINES;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IMPURITIES; LIQUIDS; OPTIMIZATION; SEPARATION;

PH EFFECTS;

ITRACONAZOLE;

ACIDITY; AQUEOUS SOLUTION; ARTICLE; CHROMATOGRAPHY; DRUG IMPURITY; DRUG ISOLATION; DRUG SCREENING; PH; PRIORITY JOURNAL; STATISTICAL MODEL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; TEMPERATURE; WATER;

EID: 70449644893     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2009.10.013     Document Type: Article

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