An Analysis of the Role of the Indigenous Microbiota in Cholesterol Gallstone Pathogenesis

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Fremont Rahl, Jacqueline J ^a,e   Ge, Zhongming ^a   Umana, Carlos ^a   Whary, Mark T ^a   Taylor, Nancy S ^a   Muthupalani, Sureshkumar ^a   Carey, Martin C ^b   Fox, James G ^a,c   Maurer, Kirk J ^d  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d Department of Obstetrics Gynecology   (United States)

^e TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; MUCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE COURSE; DISEASE PREDISPOSITION; FEMALE; GALLSTONE; INFLAMMATION; INTESTINE FLORA; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; PATHOGENESIS; PHENOTYPE; PREVALENCE; STONE FORMATION;

ANIMALS; ANIMALS, NEWBORN; BILE; CHOLELITHIASIS; CHOLESTEROL; DISEASE MODELS, ANIMAL; FEMALE; GALLSTONES; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICROBIOTA; MUCINS; PHENOTYPE; PREVALENCE;

EID: 84880790162     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070657     Document Type: Article

References (41)

1. Van Erpecum KJ, (2011) Pathogenesis of cholesterol and pigment gallstones: an update. Clin Res Hepatol Gastroenterol 35: 281-287.
2. Jungst C, Kullak-Ublick GA, Jungst D, (2006) Gallstone disease: Microlithiasis and sludge. Best Pract Res Clin Gastroenterol 20: 1053-1062.
3. Wittenburg H, (2010) Hereditary liver disease: gallstones. Best Pract Res Clin Gastroenterol 24: 747-756.
4. Katsika D, Grjibovski A, Einarsson C, Lammert F, Lichtenstein P, et al. (2005) Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs. Hepatology 41: 1138-1143.
5. Carey MC, Paigen B, (2002) Epidemiology of the American Indians' burden and its likely genetic origins. Hepatology 36: 781-791.
6. Maurer KJ, Rao VP, Ge Z, Rogers AB, Oura TJ, et al. (2007) T-cell function is critical for murine cholesterol gallstone formation. Gastroenterology 133: 1304-1315.
7. Liu B, Beral V, Balkwill A, Green J, Sweetland S, et al. (2008) Gallbladder disease and use of transdermal versus oral hormone replacement therapy in postmenopausal women: prospective cohort study. BMJ 337: a386.
8. Volzke H, Baumeister SE, Alte D, Hoffmann W, Schwahn C, et al. (2005) Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion 71: 97-105.
9. Maurer KJ, Ihrig MM, Rogers AB, Ng V, Bouchard G, et al. (2005) Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology 128: 1023-1033.
10. Dewhirst FE, Chien CC, Paster BJ, Ericson RL, Orcutt RP, et al. (1999) Phylogeny of the defined murine microbiota: altered Schaedler flora. Appl Environ Microbiol 65: 3287-3292.
11. Singer SM, Nash TE, (2000) The role of normal flora in Giardia lamblia infections in mice. J Infect Dis 181: 1510-1512.
12. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, et al. (2009) A core gut microbiome in obese and lean twins. Nature 457: 480-484.
13. Turnbaugh PJ, Backhed F, Fulton L, Gordon JI, (2008) Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3: 213-223.
14. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, et al. (2008) Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455: 1109-1113.
15. Potter M (1985) History of the BALB/c family. The BALB/c Mouse: Genetics and Immunology, Current Topics in Microbiology and Immunology, Vol 122 New York: Springer-Verlag. 1-5.
16. Hilgers J, van Nie R, Ivanyi D, Hilkens J, Michalides R, et al. (1985) Genetic differences in BALB/c sublines. Curr Top Microbiol Immunol 122: 19-30.
17. Petkov PM, Ding Y, Cassell MA, Zhang W, Wagner G, et al. (2004) An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Res 14: 1806-1811.
18. Sarma-Rupavtarm RB, Ge Z, Schauer DB, Fox JG, Polz MF, (2004) Spatial distribution and stability of the eight microbial species of the altered schaedler flora in the mouse gastrointestinal tract. Appl Environ Microbiol 70: 2791-2800.
19. Lofgren JL, Whary MT, Ge Z, Muthupalani S, Taylor NS, et al. (2011) Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. Gastroenterology 140: 210-220.
20. Whary MT, Taylor NS, Feng Y, Ge Z, Muthupalani S, et al. (2011) Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-)) mice. Immunology 133: 165-178.
21. Wang DQ, Paigen B, Carey MC, (1997) Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile. J Lipid Res 38: 1395-1411.
22. Delzenne NM, Neyrinck AM, Backhed F, Cani PD, (2011) Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol 7: 639-646.
23. Kootte RS, Vrieze A, Holleman F, Dallinga-Thie GM, Zoetendal EG, et al. (2012) The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes Metab 14: 112-120.
24. Tilg H, Kaser A, (2011) Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 121: 2126-2132.
25. Khanuja B, Cheah YC, Hunt M, Nishina PM, Wang DQ, et al. (1995) Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc Natl Acad Sci U S A 92: 7729-7733.
26. Wang DQ, Afdhal NH, (2004) Genetic analysis of cholesterol gallstone formation: searching for Lith (gallstone) genes. Curr Gastroenterol Rep 6: 140-150.
27. Jones SA, (2012) Physiology of FGF15/19. Adv Exp Med Biol 728: 171-182.
28. van Berge Henegouwen GP, Hofmann AF, (1978) Nocturnal gallbladder storage and emptying in gallstone patients and healthy subjects. Gastroenterology 75: 879-885.
29. Palazzo M, Balsari A, Rossini A, Selleri S, Calcaterra C, et al. (2007) Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion. J Immunol 178: 4296-4303.
30. Wang HH, Afdhal NH, Gendler SJ, Wang DQ, (2004) Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice. Am J Physiol Gastrointest Liver Physiol 287: G547-554.
31. Honda K, Littman DR, (2012) The microbiome in infectious disease and inflammation. Annu Rev Immunol 30: 759-795.
32. McGuckin MA, Linden SK, Sutton P, Florin TH, (2011) Mucin dynamics and enteric pathogens. Nat Rev Microbiol 9: 265-278.
33. Sharma R, Young C, Neu J, (2010) Molecular modulation of intestinal epithelial barrier: contribution of microbiota. J Biomed Biotechnol 2010: 305879.
34. Ljungh A, Wadstrom T, (2006) Lactic acid bacteria as probiotics. Curr Issues Intest Microbiol 7: 73-89.
35. Hayashi T, Ishida T, Motoya S, Itoh F, Takahashi T, et al. (2001) Mucins and immune reactions to mucins in ulcerative colitis. Digestion 63Suppl 1: 28-31.
36. Snyder JD, Walker WA, (1987) Structure and function of intestinal mucin: developmental aspects. Int Arch Allergy Appl Immunol 82: 351-356.
37. Behar J, Mawe GM, Carey MC, (2013) Roles of cholesterol and bile salts in the pathogenesis of gallbladder hypomotility and inflammation: cholecystitis is not caused by cystic duct obstruction. Neurogastroenterol Motil 25: 283-290.
38. Wang HH, Afdhal NH, Gendler SJ, Wang DQ, (2006) Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice. Gastroenterology 131: 210-222.
39. Backhed F, Crawford PA, (2010) Coordinated regulation of the metabolome and lipidome at the host-microbial interface. Biochim Biophys Acta 1801: 240-245.
40. Ley RE, (2010) Obesity and the human microbiome. Curr Opin Gastroenterol 26: 5-11.
41. Morowitz MJ, Carlisle EM, Alverdy JC (2011) Contributions of intestinal bacteria to nutrition and metabolism in the critically ill. Surg Clin North Am 91: 771-785, viii.