Mucins and immune reactions to mucins in ulcerative colitis

Digestion

Volumn 63, Issue SUPPL. 1, 2001, Pages 28-31

  Hayashi, Toshiaki ^a,c   Ishida, Tadao ^a   Motoya, Satoshi ^a   Itoh, Fumio ^a   Takahashi, Tohru ^a   Hinoda, Yuji ^b   Imai, Kohzoh ^a  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

^b YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Antibody dependent cell mediated cytotoxicity; Cytotoxic T lymphocytes; Goblet cell; MUC1; MUC2; Sulphation

Indexed keywords

MUCIN;

ADOLESCENT; ADULT; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONFERENCE PAPER; FEMALE; HUMAN; HUMORAL IMMUNITY; MALE; PATHOGENESIS; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ANTIBODIES; ANTIBODY FORMATION; COLITIS, ULCERATIVE; HUMANS; IMMUNITY, CELLULAR; INTESTINAL MUCOSA; MUCINS;

EID: 0035136535     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000051907     Document Type: Conference Paper

References (27)

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3. r40K protein on colonic adenocarcinoma cells for antibody-dependent cellular cytotoxicity
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5. Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis
6. Detection of a circulating antibody against a peptide epitope on a mucin core protein, MUC1, in ulcerative colitis
7. Circulating autoantibodies against purified colonic mucin in ulcerative colitis
8. Cloning and sequencing of a human pancreatic tumor mucin cDNA
9. Human epithelial tumor antigen cDNA sequences. Differential splicing may generate multiple protein forms
10. Thickness of adherent mucus gel on colonic mucosa in human and its relevance to colitis
11. Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis
12. Altered expression of mucins throughout the colon in ulcerative colitis
13. Glycosylation and sulphation of colonic mucus glycoproteins in patients with ulcerative colitis and in healthy subjects
14. Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women
15. Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin
16. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor target
17. The production and preclinical characterization of chimeric anti-breast-cancer antibody, cBC2
18. Detection of circulating anti-MUC1 mucin core protein antibodies in patients with colorectal cancer
19. Major histocompatibility antigen-restricted cytotoxicity in inflammatory bowel disease
20. Generation of MHC class I-restricted cytotoxic T cell lines and clones against colonic epithelial cells from ulcerative colitis
21. Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease
22. Specific, major histocompatibility complex-unrestricted recognition of tumor associated mucins by human cytotoxic T cells
23. Expression of MUC1 on myeloma cells and induction of HLA-unrestricted cytotoxic T lymphocytes against MUC1 from a multiple myeloma patient
24. Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin
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26. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2
27. Serum levels of CD30 are increased in ulcerative colitis (UC) but not in Crohn's disease (CD)