Behaviour of Non-Donor Specific Antibodies during Rapid Re-Synthesis of Donor Specific HLA Antibodies after Antibody Incompatible Renal Transplantation

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Krishnan, Nithya S ^a   Zehnder, Daniel ^a,c   Daga, Sunil ^a,c   Lowe, Dave ^b   Lam, F T ^a   Kashi, Habib ^a   Tan, Lam Chin ^a   Imray, Christopher ^a   Hamer, Rizwan ^a   Briggs, David ^b   Raymond, Neil ^c   Higgins, Robert M ^a  

^a UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD GROUP ANTIBODY; CYTOKINE; HEPATITIS B SURFACE ANTIBODY; HLA ANTIBODY; HLA ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TACROLIMUS;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BEHAVIOR; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; KIDNEY DONOR; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PLASMAPHERESIS; UNITED KINGDOM;

ADULT; ANTIBODIES; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; FEMALE; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; KIDNEY TRANSPLANTATION; LOGISTIC MODELS; MALE; TISSUE DONORS;

EID: 84880786889     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068663     Document Type: Article

References (27)

1. Locke JE, Zachary AA, Warren DS, Segev DL, Houp JA, et al. (2009) Proinflammatory events are associated with significant increases in breadth and strength of HLA-specific antibody. Am J Transplant Sep (9): 2136-9.
2. Aiello FB, Calabrese F, Rigotti P, Furian L, Marino S, et al. (2004) Acute rejection and graft survival in renal transplanted patients with viral diseases. Mod Pathol. Feb 17(2): 189-96.
3. Forman JP, Tolkoff-Rubin N, Pascual M, Lin J, (2004) Hepatitis C, acute humoral rejection, and renal allograft survival. J Am Soc Nephrol. Dec 15(12): 3249-55.
4. Morris PJ, Monaco AP, (2004) Antibody revisited. Transplantation 78: 179-80.
5. Shimmura H, Tanabe K, Ishida H, Tokumoto T, Ishikawa N, et al. (2005) Lack of correlation between results of ABO-incompatible living kidney transplantation and anti-ABO blood type antibody titers under our current immunosuppression. Transplantation. Oct 15 80(7): 985-8.
6. Tanabe K, Tokumoto T, Ishida H, Toma H, Nakajima I, et al. (2003) ABO-incompatible renal transplantation at Tokyo Women's Medical University. Clinical Transplants, Cecka and Tersaki, 175-181.
7. Haas M, Rahman MH, Racusen LC, Kraus ES, Bagnasco SM, et al. (2006) C4d and C3d staining in biopsies of ABO- and HLA-incompatible renal allografts: correlation with histologic findings. Am J Transplant 6: 1829-40.
8. Tyden G, Kumlien G, Genberg H, Sandberg J, Lundgren T, et al. (2005) ABO incompatible kidney transplantations without splenectomy, using antigen-specific immunoadosprtion and rituximab. Am J Transplant 5: 145-8.
9. Higgins R, Lowe D, Hathaway M, Lam FT, Kashi H, et al. (2009) Rises and falls in donor-specific and third-party HLA antibody levels after antibody incompatible transplantation. Transplantation. Mar 27 87(6): 882-8.
10. Briggs D, Zehnder D, Higgins RM, (2009) Development of non-donor-specific HLA antibodies after kidney transplantation: frequency and clinical implications. Contrib Nephrol. 162: 107-16.
11. Sis B, Mengel M, Haas M, Colvin RB, Halloran PF, et al. (2010) Banff '09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups American Journal of Transplantation March Volume 10, Issue 3, pages 464-471.
12. Collins AB, Schneeberger EE, Pascual MA, Saidman SL, Williams WW, et al. (1999) Complement activation in acute humoral renal allograft rejection: Diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol 10: 2208-2214.
13. Monteiro F, Rodrigues H, Kalil J, Castro MC, Panajotopoulos N, et al. (2012) Pre- and posttransplant monitoring of alloantibodies by complement-dependent cytotoxicity and luminex methodologies in liver transplantation. Transplant Proc. Oct 44(8): 2411-2.
14. Krishnan NS, Fleetwood P, Higgins RM, Hathway M, Zehnder D, et al. (2008) Application of flow cytometry to monitor antibody levels in ABO incompatible kidney transplantation. Transplantation. Aug 15 86(3): 474-7.
15. Burgess C, Mitchell N, Perry KR (2009) Evaluation report: Evaluation of six Cytomegalovirus. IgG/total antibody kits suitable for use in the UK National Blood Service http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317133422489.
16. Tuder RM, Weinberg A, Panajotopoulos N, Kalil J, (1994) Cytomegalovirus infection amplifies class I major histocompatibility complex expression on cultured human endothelial cells. J Heart Lung Transplant. Jan-Feb; 13(1 Pt 1): 129-38.
17. Di Genova G, Roddick J, McNicholl F, Stevenson FK, (2006) Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific Blood. Apr 1 107(7): 2806-13.
18. Candon S, Thervet E, Lebon P, Suberbielle C, Zuber J, et al. (2009) Humoral and cellular immune responses after influenza vaccination in kidney transplant recipients. Am J Transplant. Oct 9(10): 2346-54.
19. Avery RK, Michaels M, (2008) Update on immunizations in solid organ transplant recipients: what clinicians need to know. Am J Transplant. Jan 8(1): 9-14.
20. Vilchez RA, McCurry K, Dauber J, Lacono A, Griffith B, et al. (2002) Influenza virus infection in adult solid organ transplant recipients. Am J Transplant. Mar 2(3): 287-91.
21. Adams AB, Pearson TC, Larsen CP (2003) Heterologous immunity: an overlooked barrier to tolerance. Immunol Rev. Dec; 196: 147-60. Review.
22. Roddy M, Clemente M, Poggio ED, Bukowski R, Thakkar S, et al. (2005) Heterogeneous alterations in human alloimmunity associated with immunization. Transplantation. Aug 15 80(3): 297-302.
23. Bernasconi NL, Traggiai E, Lanzavecchia A, (2002) Maintenance of serological memory by polyclonal activation of human memory B cells. Science. Dec 13 298(5601): 2199-202.
24. Katerinis I, Hadaya K, Duquesnoy R, Ferrari-Lacraz S, Meier S, et al. (2011) De novo anti-HLA antibody after pandemic H1N1 and seasonal influenza immunization in kidney transplant recipients. Am J Transplant. Aug 11(8): 1727-33.
25. Amanna IJ, Carlson NE, Slifka MK, (2007) Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med 357: 1903-1915.
26. Zachary AA, Montgomery RA, Ratner LE, Samaniego-Picota M, Haas M, et al. (2003) Specific and durable elimination of antibody to donor HLA antigens in renal-transplant patients. Transplantation. Nov 27 76(10): 1519-25.
27. Rentenaar RJ, van Diepen FN, Meijer RT, Surachno S, Wilmink JM, et al. (2002) Immune responsiveness in renal transplant recipients: mycophenolic acid severely depresses humoral immunity in vivo. Kidney Int. Jul 62(1): 319-28.