Chronic Alterations in Monoaminergic Cells in the Locus Coeruleus in Orexin Neuron-Ablated Narcoleptic Mice

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Tsujino, Natsuko ^a,b   Tsunematsu, Tomomi ^c   Uchigashima, Motokazu ^d   Konno, Kohtarou ^d   Yamanaka, Akihiro ^c   Kobayashi, Kazuto ^e   Watanabe, Masahiko ^d   Koyama, Yoshimasa ^f   Sakurai, Takeshi ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

^d HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^f FUKUSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 3; OREXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; GABAERGIC TRANSMISSION; INHIBITORY POSTSYNAPTIC POTENTIAL; LOCUS CERULEUS; MONOAMINE NERVE CELL; MOUSE; NARCOLEPSY; NONHUMAN; NONREM SLEEP; NORADRENERGIC NERVE; PATCH CLAMP; SEROTONINERGIC NERVE CELL; WAKEFULNESS;

ADRENERGIC NEURONS; ANIMALS; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LOCUS COERULEUS; MALE; MICE; MICE, TRANSGENIC; NARCOLEPSY; NEUROPEPTIDES; PATCH-CLAMP TECHNIQUES; RAPHE NUCLEI; SEROTONERGIC NEURONS;

EID: 84880776712     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070012     Document Type: Article

References (43)

1. Sakurai T, (2007) The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 8: 171-181.
2. Sakurai T, Mieda M, (2011) Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal. Trends Pharmacol Sci 32: 451-462.
3. Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, et al. (1999) Distribution of orexin neurons in the adult rat brain. Brain Res 827: 243-260.
4. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, et al. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18: 9996-10015.
5. Trulson ME, Jacobs BL, (1979) Raphe unit activity in freely moving cats: correlation with level of behavioral arousal. Brain Res 163: 135-150.
6. Hobson JA, McCarley RW, Wyzinski PW, (1975) Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups. Science 189: 55-58.
7. Puizillout JJ, Gaudin-Chazal G, Daszuta A, Seyfritz N, Ternaux JP, (1979) Release of endogenous serotonin from "encephale isole" cats. II- Correlations with raphe neuronal activity and sleep and wakefulness. J Physiol (Paris) 75: 531-537.
8. Foote SL, Aston-Jones G, Bloom FE, (1980) Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal. Proc Natl Acad Sci U S A 77: 3033-3037.
9. Vanni-Mercier G, Sakai K, Jouvet M, (1984) [Specific neurons for wakefulness in the posterior hypothalamus in the cat]. C R Acad Sci III 298: 195-200.
10. Szymusiak R, Iriye T, McGinty D, (1989) Sleep-waking discharge of neurons in the posterior lateral hypothalamic area of cats. Brain Res Bull 23: 111-120.
11. Portas CM, Bjorvatn B, Fagerland S, Gronli J, Mundal V, et al. (1998) On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat. Neuroscience 83: 807-814.
12. Park SP, Lopez-Rodriguez F, Wilson CL, Maidment N, Matsumoto Y, et al. (1999) In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness. Brain Res 833: 291-296.
13. Strecker RE, Thakkar MM, Porkka-Heiskanen T, Dauphin LJ, Bjorkum AA, et al. (1999) Behavioral state-related changes of extracellular serotonin concentration in the pedunculopontine tegmental nucleus: a microdialysis study in freely moving animals. Sleep Res Online 2: 21-27.
14. Shouse MN, Staba RJ, Saquib SF, Farber PR, (2000) Monoamines and sleep: microdialysis findings in pons and amygdala. Brain Res 860: 181-189.
15. Strecker RE, Nalwalk J, Dauphin LJ, Thakkar MM, Chen Y, et al. (2002) Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study. Neuroscience 113: 663-670.
16. Chu M, Huang ZL, Qu WM, Eguchi N, Yao MH, et al. (2004) Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats. Neurosci Res 49: 417-420.
17. Lena I, Parrot S, Deschaux O, Muffat-Joly S, Sauvinet V, et al. (2005) Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep-wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats. J Neurosci Res 81: 891-899.
18. Mieda M, Hasegawa E, Kisanuki YY, Sinton CM, Yanagisawa M, et al. (2011) Differential roles of orexin receptor-1 and-2 in the regulation of non-REM and REM sleep. J Neurosci 31: 6518-6526.
19. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, et al. (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435: 6-25.
20. Brown RE, Sergeeva OA, Eriksson KS, Haas HL, (2002) Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). J Neurosci 22: 8850-8859.
21. Liu RJ, van den Pol AN, Aghajanian GK, (2002) Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J Neurosci 22: 9453-9464.
22. Takahashi K, Wang QP, Guan JL, Kayama Y, Shioda S, et al. (2005) State-dependent effects of orexins on the serotonergic dorsal raphe neurons in the rat. Regul Pept 126: 43-47.
23. Lee MG, Hassani OK, Jones BE, (2005) Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 25: 6716-6720.
24. Mileykovskiy BY, Kiyashchenko LI, Siegel JM, (2005) Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46: 787-798.
25. Takahashi K, Lin JS, Sakai K, (2008) Neuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouse. Neuroscience 153: 860-870.
26. Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, et al. (2004) Behavioral state instability in orexin knock-out mice. J Neurosci 24: 6291-6300.
27. Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, et al. (2001) Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30: 345-354.
28. Wu MF, John J, Boehmer LN, Yau D, Nguyen GB, et al. (2004) Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs. J Physiol 554: 202-215.
29. Takahashi K, Kayama Y, Lin JS, Sakai K, (2010) Locus coeruleus neuronal activity during the sleep-waking cycle in mice. Neuroscience 169: 1115-1126.
30. Wu MF, Gulyani SA, Yau E, Mignot E, Phan B, et al. (1999) Locus coeruleus neurons: cessation of activity during cataplexy. Neuroscience 91: 1389-1399.
31. Urbain N, Creamer K, Debonnel G, (2006) Electrophysiological diversity of the dorsal raphe cells across the sleep-wake cycle of the rat. J Physiol 573: 679-695.
32. Koyama Y, Kayama Y, (1993) Mutual interactions among cholinergic, noradrenergic and serotonergic neurons studied by ionophoresis of these transmitters in rat brainstem nuclei. Neuroscience 55: 1117-1126.
33. Gervasoni D, Darracq L, Fort P, Souliere F, Chouvet G, et al. (1998) Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA during sleep. Eur J Neurosci 10: 964-970.
34. Goutagny R, Luppi P, Salvert D, Lapray D, Gervasoni D, et al. (2008) Role of the dorsal paragigantocellular reticular nucleus in paradoxical (rapid eye movement) sleep generation: a combined electrophysiological and anatomical study in the rat. Neuroscience 152: 849-857.
35. Verret L, Fort P, Gevasoni D, Léger L, Luppi P, (2006) Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat. J Comp Neurol 495: 573-586.
36. Matsushita N, Okada H, Yasoshima Y, Takahashi K, Kiuchi K, et al. (2002) Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development. J Neurochem 82: 295-304.
37. Koyama Y, Hayaishi O, (1994) Firing of neurons in the preoptic/anterior hypothalamic areas in rat: its possible involvement in slow wave sleep and paradoxical sleep. Neurosci Res 19: 31-38.
38. Koyama Y, Jodo E, Kayama Y, (1994) Sensory responsiveness of "broad-spike" neurons in the laterodorsal tegmental nucleus,locus coeruleus and dorsal raphe of awake rats: implications for cholinergic and monoaminergic neuron-specific responses. Neuroscience 63: 1021-1031.
39. Radulovacki M, Virus RM, Djuricic-Nedelson M, Green RD, (1984) Adenosine analogs and sleep in rats. J Pharmacol Exp Ther 228: 268-274.
40. Taneja P, Ogier M, Brooks-Harris G, Schmid D, Katz D, et al. (2009) Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome. J Neurosci 29: 12187-12195.
41. Uchigashima M, Narushima M, Fukaya M, Katona I, Kano M, et al. (2007) Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. J Neurosci 27: 3663-3676.
42. Miyazaki T, Fukaya M, Shimizu H, Watanabe M, (2003) Developmental switching of vesicular glutamate transporters at parallel fiber-Purkinje cell synapses. Eur J Neurosci 17: 2563-2572.
43. Fukudome Y, Ohno-Shosaku T, Matsui M, Omori Y, Fukaya M, et al. (2004) Two distinct classes of muscarinic action on hippoccampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signaling. Eur J Neurosci 19: 2682-2692.