Serum Uric Acid and Non-Alcoholic Fatty Liver Disease in Non-Diabetic Chinese Men

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Xie, Yuanliang ^a   Wang, Mengjie ^b   Zhang, Youjie ^a   Zhang, Shijun ^b   Tan, Aihua ^b   Gao, Yong ^b   Liang, Zhengjia ^c   Shi, Deyi ^c   Huang, Zhang ^c   Zhang, Haiying ^b   Yang, Xiaobo ^b   Lu, Zheng ^a   Wu, Chunlei ^a   Liao, Ming ^a   Sun, Yu ^a   Qin, Xue ^a   Hu, Yanling ^b   Li, Li ^b   Peng, Tao ^a   Li, Zhixian ^a   Yang, Xiaoli ^b   Mo, Zengnan ^a,b   more..

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

^c Fangchenggang First People's Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ARGININE; C REACTIVE PROTEIN; CREATININE; GLUTAMINE; INSULIN; LYSINE; METHIONINE; TRIACYLGLYCEROL; URIC ACID;

ABCG2 GENE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CHINESE; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; GENE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HYPERTRIGLYCERIDEMIA; HYPERURICEMIA; INFLAMMATION; INSULIN RESISTANCE; LIPID METABOLISM; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PREDICTION; RISK FACTOR; SMOKING; TNFRSF1B GENE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CONFIDENCE INTERVALS; DIABETES MELLITUS; FATTY LIVER; HUMANS; LINEAR MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; ODDS RATIO; URIC ACID; YOUNG ADULT;

EID: 84880745010     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067152     Document Type: Article

References (41)

1. Angulo P, (2002) Nonalcoholic fatty liver disease. N Engl J Med 346: 1221-1231.
2. Gu D, Reynolds K, Wu X, Chen J, Duan X, et al. (2005) Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 365: 1398-1405.
3. Fan JG, Zhu J, Li XJ, Chen L, Li L, et al. (2005) Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol 43: 508-514.
4. Hou XH, Zhu YX, Lu HJ, Chen HF, Li Q, et al. (2011) Non-alcoholic fatty liver disease's prevalence and impact on alanine aminotransferase associated with metabolic syndrome in the Chinese. J Gastroenterol Hepatol 26: 722-730.
5. Choi SS, Diehl AM, (2008) Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol 19: 295-300.
6. Xu C, Yu C, Xu L, Miao M, Li Y, (2010) High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study. PLoS One 5: e11578.
7. Ryu S, Chang Y, Kim SG, Cho J, Guallar E, (2011) Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. Metabolism 60: 860-866.
8. Li Y, Xu C, Yu C, Xu L, Miao M, (2009) Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study. J Hepatol 50: 1029-1034.
9. Afzali A, Weiss NS, Boyko EJ, Ioannou GN, (2010) Association between serum uric acid level and chronic liver disease in the United States. Hepatology 52: 578-589.
10. Feig DI, Kang DH, Johnson RJ, (2008) Uric acid and cardiovascular risk. N Engl J Med 359: 1811-1821.
11. Gaffo AL, Edwards NL, Saag KG, (2009) Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link? Arthritis Res Ther 11: 240.
12. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ, (2007) Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol 293: C584-596.
13. Beavers KM, Beavers DP, Serra MC, Bowden RG, Wilson RL, (2009) Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III. J Nutr Health Aging 13: 177-182.
14. Powell EE, Jonsson JR, Clouston AD, (2010) Metabolic factors and non-alcoholic fatty liver disease as co-factors in other liver diseases. Dig Dis 28: 186-191.
15. Sirota JC, McFann K, Targher G, Johnson RJ, Chonchol M, et al. (2013) Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism 62: 392-399.
16. Alvarez-Lario B, Macarron-Vicente J, (2010) Uric acid and evolution. Rheumatology (Oxford) 49: 2010-2015.
17. Onat A, Uyarel H, Hergenc G, Karabulut A, Albayrak S, et al. (2006) Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens 19: 1055-1062.
18. Yoo TW, Sung KC, Shin HS, Kim BJ, Kim BS, et al. (2005) Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circ J 69: 928-933.
19. Tan A, Sun J, Xia N, Qin X, Hu Y, et al. (2012) A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. Hum Mol Genet 21: 1658-1664.
20. Tian GX, Sun Y, Pang CJ, Tan AH, Gao Y, et al. (2012) Oestradiol is a protective factor for non-alcoholic fatty liver disease in healthy men. Obes Rev 13: 381-387.
21. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, et al. (2002) The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 123: 745-750.
22. Meziri M, Pereira WC, Abdelwahab A, Degott C, Laugier P, (2005) In vitro chronic hepatic disease characterization with a multiparametric ultrasonic approach. Ultrasonics 43: 305-313.
23. Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, et al. (2005) Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 42: 44-52.
24. Fang J, Alderman MH, (2000) Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA 283: 2404-2410.
25. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
26. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, et al. (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement: Executive Summary. Crit Pathw Cardiol 4: 198-203.
27. Peng XE, Wu YL, Lin SW, Lu QQ, Hu ZJ, et al. (2012) Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population. PLoS One 7: e50256.
28. Tokushige K, Takakura M, Tsuchiya-Matsushita N, Taniai M, Hashimoto E, et al. (2007) Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis. J Hepatol 46: 1104-1110.
29. Lin YC, Chang PF, Hu FC, Chang MH, Ni YH, (2009) Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease. Pediatrics 124: e1221-1227.
30. Al-Serri A, Anstee QM, Valenti L, Nobili V, Leathart JB, et al. (2012) The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. J Hepatol 56: 448-454.
31. Dehghan A, Kottgen A, Yang Q, Hwang SJ, Kao WL, et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 372: 1953-1961.
32. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, et al. (2009) Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 5: e1000504.
33. Choi HK, Liu S, Curhan G, (2005) Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey. Arthritis Rheum 52: 283-289.
34. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, et al. (2003) Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37: 917-923.
35. Facchini F, Chen YD, Hollenbeck CB, Reaven GM, (1991) Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 266: 3008-3011.
36. de Oliveira EP, Burini RC, (2012) High plasma uric acid concentration: causes and consequences. Diabetol Metab Syndr 4: 12.
37. Kountouras J, Magoula I, Tsapas G, Liatsis I, (1996) The effect of mannitol and secretin on the biliary transport of urate in humans. Hepatology 23: 229-233.
38. Petta S, Camma C, Cabibi D, Di Marco V, Craxi A, (2011) Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther 34: 757-766.
39. Kono H, Chen CJ, Ontiveros F, Rock KL, (2010) Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest 120: 1939-1949.
40. Hoque R, Vodovotz Y, Mehal W, (2013) Therapeutic strategies in inflammasome mediated diseases of the liver. J Hepatol 58: 1047-1052.
41. Shi Y, (2010) Caught red-handed: uric acid is an agent of inflammation. J Clin Invest 120: 1809-1811.