Prothrombin complex concentrate (PCC, Octaplex®) in patients requiring immediate reversal of vitamin K antagonist anticoagulation

Thrombosis Research

Volumn 129, Issue 4, 2012, Pages 526-529

  Song, Madeline M ^a   Warne, Connor P ^a   Crowther, Mark A ^a  

^a ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTHROMBIN COMPLEX; WARFARIN;

ANTICOAGULANT THERAPY; ARTERY OCCLUSION; BLEEDING; BLOOD CELL COUNT; CONGESTIVE CARDIOMYOPATHY; DEATH; DEEP VEIN THROMBOSIS; DRUG SAFETY; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LETTER; PRIORITY JOURNAL; PROSTHETIC VALVE THROMBOSIS; SIDE EFFECT; THROMBOCYTE COUNT; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM;

ADULT; AGED; AGED, 80 AND OVER; BLOOD COAGULATION FACTORS; DRUG INTERACTIONS; FEMALE; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; THROMBOSIS; TREATMENT OUTCOME; VITAMIN K; WARFARIN;

EID: 84858337925     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.12.007     Document Type: Letter

References (12)

1. R.I. Baker, P.B. Coughlin, A.S. Gallus, P.L. Harper, H.H. Salem, and E.M. Wood Warfarin reversal consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis Med J Aust 181 2004 492 497
2. M. Makris, M. Greaves, W.S. Phillips, S. Kitchen, F.R. Rosendaal, and E.F. Preston Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of coagulopathy Thromb Haemost 77 1997 477 480
3. T. Baglin Management of warfarin (coumadin) overdose Blood Rev 12 1998 91 98
4. National Advisory Commitee on Blood and Blood Products. Recommendations for use of prothrombin complex concentrates in Canada. Updated June 29, 2011.
5. D. Josic, L. Hoffer, A. Buchacher, H. Schwinn, W. Frenzel, and L. Biesert Manufacturing of a prothombin complex concentrate aiming at low thrombogenicity Thromb Res 100 2000 433 441
6. A. Lubetsky, R. Hoffman, R. Zimlichman, A. Eldor, J. Zvi, and V. Kostenko Efficacy and safety of a prothrombin complex concentrate (Octaplex®) for rapid reversal of oral anticoagulation Thromb Res 113 2004 371 378
7. Octapharma Canada, Inc Octaplex® product monograph 2007 Octapharma Canada, Inc Brampton, ON
8. G. Evans, R. Luddington, and T. Baglin Beriplex T/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding Br J Haematol 2001 999 1001
9. F.E. Preston, S.T. Laidslaw, B. Sampson, and S. Kitchen Rapid reversal of oral anticoagulation by a prothrombin complex concentrate (beriplex): efficacy and safety in 42 patients Br J Haematol 116 2002 619 624
10. C.J. Wiedermann, and I. Stockner Warfarin - induced bleeding complications - clinical presentation and therapeutic options Thromb Res 122 Suppl. 2 2008 S13 S18
11. G. Pindur, and S. Morsdorf The use of prothrombin complex concentrates in the treatment of hemorrhages induced by oral anticoagulation Thromb Res 95 Suppl. 2 1999 S57 S61
12. T.P. Baglin, D.M. Keeling, and H.G. Watson Guidelines on oral anticoagulation (warfarin): third edition - 2005 update Br J Haematol 132 2005 277 285