Emergence of an extensively drug-resistant armA- and KPC-2-producing st101 klebsiella pneumoniae clone in Italy

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 8, 2013, Pages 1932-1934

  Mezzatesta, Maria Lina ^a   Gona, Floriana ^a   Caio, Carla ^a   Adembri, Chiara ^b   Dell'utri, Pia ^c   Santagati, Maria ^a   Stefani, Stefania ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

^c IRCCS Neurolesi Bonino Pulejo   (Italy)

Author keywords

16S rRNA methylase; Carbapenemases; Multidrug resistance; Tn4401

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE DERIVATIVE; AMINOGLYCOSIDE MODIFYING ENZYME; BETA LACTAMASE; CARBAPENEM DERIVATIVE; COLISTIN; GENTAMICIN; KANAMYCIN; TIGECYCLINE; UNCLASSIFIED DRUG;

ALLELE; ANTIBIOTIC RESISTANCE; BACTERIAL STRAIN; BACTERIUM ISOLATE; EXTENSIVELY DRUG RESISTANT KLEBSIELLA PNEUMONIAE; GENE AMPLIFICATION; GENE SEQUENCE; HORIZONTAL GENE TRANSFER; HUMAN; INFECTION CONTROL; ITALY; KLEBSIELLA PNEUMONIAE; LETTER; MULTILOCUS SEQUENCE TYPING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PLASMID;

16S RRNA METHYLASE; CARBAPENEMASES; MULTIDRUG RESISTANCE; TN4401;

ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CLUSTER ANALYSIS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; ITALY; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MULTILOCUS SEQUENCE TYPING; TRNA METHYLTRANSFERASES;

EID: 84880708682     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt116     Document Type: Letter

References (10)

1. Chen LF, Anderson DJ, Paterson DL. Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance. Infect Drug Resist 2012; 5: 133-41.
2. Mammina C, Bonura C, Aleo A et al. Sequence type 101 (ST101) as the predominant carbapenem-non-susceptible Klebsiella pneumoniae clone in an acute general hospital in Italy. Int J Antimicrob Agents 2012; 39: 543-5.
3. Frasson I, Lavezzo E, Franchin E et al. Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced blaKPC-2 plasmid. J Clin Microbiol 2012; 50: 3768-72.
4. DHA-1, qnrB4, and armA. Antimicrob Agents Chemother 2010; 54: 3967-9.
5. Zacharczuk K, Piekarska K, Szych J et al. Emergence of Klebsiella pneumoniae coproducing KPC-2 and 16S rRNA methylase ArmA in Poland. Antimicrob Agents Chemother 2011; 55: 443-6.
6. Garćia-Fernández A, Villa L, Carta C et al. Klebsiella pneumoniae ST258 producing KPC-3 identified in Italy carries novel plasmids and OmpK36/ OmpK35 porin variants. Antimicrob Agents Chemother 2012; 56: 2143-5.
7. Mezzatesta ML, Gona F, Caio C et al. Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals. Clin Microbiol Infect 2011; 17: 1444-7.
8. Gona F, Mezzatesta ML, Corona D et al. Klebsiella pneumoniae ESBL producers responsible for severe UTIs in a renal transplant unit. Infection 2011; 39: 83-5.
9. Perilli M, Mezzatesta ML, Falcone M et al. Class I integron-borne blaVIM-1 carbapenemase in a strain of Enterobacter cloacae responsible for a case of fatal pneumonia. Microb Drug Resist 2008; 14: 45-7.
10. Gootz TD, Lescoe MK, Dib-Hajj F et al. Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. Antimicrob Agents Chemother 2009; 53: 1998-2004.