Engineering axially vascularized bone in the sheep arteriovenous-loop model

Journal of Tissue Engineering and Regenerative Medicine

Volumn 7, Issue 8, 2013, Pages 654-664

  Boos, Anja M ^a   Loew, Johanna S ^a   Weigand, Annika ^a   Deschler, Gloria ^a   Klumpp, Dorothee ^a   Arkudas, Andreas ^a   Bleiziffer, Oliver ^a   Gulle, Heinz ^b   Kneser, Ulrich ^a   Horch, Raymund E ^a   Beier, Justus P ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b BAXTER INNOVATIONS GMBH   (Austria)

Author keywords

Axially vascularized bone tissue; Mesenchymal stem cells; RhBMP 2; Sheep arteriovenous loop model; Tissue engineering; Transplantable bone tissue

Indexed keywords

BONE; COMPUTERIZED TOMOGRAPHY; FLOWCHARTING; GRANULATION; HYDROXYAPATITE; MAGNETIC RESONANCE IMAGING; RECOMBINANT PROTEINS; STEM CELLS; TISSUE ENGINEERING; TRANSMISSION CONTROL PROTOCOL;

AXIALLY VASCULARIZED BONE TISSUE; BONE TISSUE; HUMAN BONE MORPHOGENETIC PROTEIN; LOOP MODELS; MESENCHYMAL STEM CELL; RHBMP-2; SHEEP ARTERIOVENOUS-LOOP MODEL; TISSUES ENGINEERINGS; TRANSPLANTABLE BONE TISSUE;

CELL CULTURE;

CALCIUM PHOSPHATE; COLLAGEN TYPE 1; HYDROXYAPATITE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTERIOVENOUS LOOP MODEL; ARTICLE; AUTOTRANSPLANTATION; BONE DEFECT; BONE GRAFT; BONE TISSUE; CELL PROLIFERATION; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE ANGIOGRAPHY; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; MICROSURGERY; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; SHEEP; TISSUE ENGINEERING; VASCULARIZATION;

EID: 84880703950     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1457     Document Type: Article

References (37)

1. Arkudas A, Beier JP, Heidner K, et al. 2007; Axial prevascularization of porous matrices using an arteriovenous loop promotes survival and differentiation of transplanted autologous osteoblasts. Tissue Eng 13: 1549-1560.
2. Arvidson K, Abdallah BM, Applegate LA, et al. 2011; Bone regeneration and stem cells. J Cell Mol Med 15(4): 718-746.
3. Bais MV, Wigner N, Young M, et al. 2009; BMP2 is essential for postnatal osteogenesis but not for recruitment of osteogenic stem cells. Bone 45: 254-266.
4. Balcik C, Tokdemir T, Senkoylu A, et al. 2007; Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: a longitudinal study in a segmental bone defect model of rabbit. Acta Biomater 3: 985-996.
5. Beier JP, Hess A, Loew J, et al. 2011; De novo generation of an axially vascularized processed bovine cancellous bone substitute in the sheep arteriovenous-loop model. Eur Surg Res 46: 148-155.
6. Beier JP, Horch RE, Arkudas A, et al. 2009; De novo generation of axially vascularized tissue in a large animal model. Microsurgery 29: 42-51.
7. Beier JP, Horch RE, Hess A, et al. 2010; Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model. J Tissue Eng Regen Med 4: 216-223.
8. Bensaid W, Oudina K, Viateau V, et al. 2005; De novo reconstruction of functional bone by tissue engineering in the metatarsal sheep model. Tissue Eng 11: 814-824. 2005.
9. Bodde EW, Wolke JG, Kowalski RS, et al. 2007; Bone regeneration of porous β-tricalcium phosphate (Conduit TCP) and of biphasic calcium phosphate ceramic (Biosel) in trabecular defects in sheep. J Biomed Mater Res A 82: 711-722.
10. Boos AM, Loew JS, Deschler G, et al. 2011; Directly auto-transplanted mesenchymal stem cells induce bone formation in a ceramic bone substitute in an ectopic sheep model. J Cell Mol Med 15(6): 1364-1378.
11. Chen J, Zhang ZG, Li Y, et al. 2003; Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 92: 692-699.
12. Cheng MH, Brey EM, Allori AC, et al. 2009; Periosteum-guided prefabrication of vascularized bone of clinical shape and volume. Plast Reconstr Surg 124: 787-795.
13. Deschaseaux F, Pontikoglou C, Sensebe L 2010; Bone regeneration: the stem/progenitor cells point of view. J Cell Mol Med 14(1-2): 103-115.
14. Dolderer JH, Abberton KM, Thompson EW, et al. 2007; Spontaneous large volume adipose tissue generation from a vascularized pedicled fat flap inside a chamber space. Tissue Eng 13: 673-681.
15. El-Adl G, Mostafa MF, Enan A, et al. 2009; Biphasic ceramic bone substitute mixed with autogenous bone marrow in the treatment of cavitary benign bone lesions. Acta Orthop Belg 75: 110-118.
16. Erol OO, Spira M. 1979; New capillary bed formation with a surgically constructed arteriovenous fistula. Surg Forum 30: 530-531.
17. Eweida AM, Nabawi AS, Marei MK, et al. 2011; Mandibular reconstruction using an axially vascularized tissue-engineered construct. Ann Surg Innov Res 5: 2.
18. Eyckmans J, Roberts SJ, Schrooten J, et al. 2010; A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling. J Cell Mol Med 14: 1845-1856.
19. Gao Q, Tong W, Luria JS, et al. 2010; Effects of bone morphogenetic protein-2 on proliferation and angiogenesis in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 39: 266-271.
20. Garrison KR, Shemilt I, Donell S, et al. 2010; Bone morphogenetic protein (BMP) for fracture healing in adults. Cochrane Database Syst Rev CD006950.
21. Heliotis M, Lavery KM, Ripamonti U, et al. 2006; Transformation of a prefabricated hydroxyapatite/osteogenic protein-1 implant into a vascularised pedicled bone flap in the human chest. Int J Oral Maxillofac Surg 35: 265-269.
22. Inoda H, Yamamoto G, Hattori T. 2007; ; ?>rh-BMP2-induced ectopic bone for grafting critical size defects: a preliminary histological evaluation in rat calvariae. Int J Oral Maxillofac Surg 36: 39-44.
23. Jones AL, Bucholz RW, Bosse MJ, et al. 2006; Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J Bone Joint Surg Am 88: 1431-1441.
24. Kneser U, Polykandriotis E, Ohnolz J, et al. 2006; Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng 12: 1721-1731.
25. Kon E, Muraglia A, Corsi A, et al. 2000; Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. J Biomed Mater Res 49: 328-337.
26. Kreja L, Brenner RE, Tautzenberger A, et al. 2010; Non-resorbing osteoclasts induce migration and osteogenic differentiation of mesenchymal stem cells. J Cell Biochem 109: 347-355.
27. Lee K, Chan CK, Patil N, et al. 2009; Cell therapy for bone regeneration - bench to bedside. J Biomed Mater Res B Appl Biomater 89: 252-263.
28. Mian R, Morrison WA, Hurley JV, et al. 2000; Formation of new tissue from an arteriovenous loop in the absence of added extracellular matrix. Tissue Eng 6: 595-603.
29. Niemeyer P, Fechner K, Milz S, et al. 2010; Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma. Biomaterials 31(13): 3572-3579.
30. Pirraco RP, Marques AP, Reis RL. 2010; Cell interactions in bone tissue engineering. J Cell Mol Med 14: 93-102.
31. Pneumaticos SG, Triantafyllopoulos GK, Basdra EK, et al. 2010; Segmental bone defects: from cellular and molecular pathways to the development of novel biological treatments. J Cell Mol Med 14: 2561-2569.
32. Pribaz JJ, Fine NA. 1994; Prelamination: defining the prefabricated flap - a case report and review. Microsurgery 15: 618-623.
33. Quarto R, Mastrogiacomo M, Cancedda R, et al. 2001; Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344: 385-386.
34. Tampieri A, Celotti G, Szontagh F, et al. 1997; Sintering and characterization of HA and TCP bioceramics with control of their strength and phase purity. J Mater Sci Mater Med 8: 29-37.
35. Terheyden H, Knak C, Jepsen S, et al. 2001; Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1: an experimental study in miniature pigs. Part I: Prefabrication. Int J Oral Maxillofac Surg 30: 373-379.
36. Warnke PH, Springer IN, Wiltfang J, et al. 2006; Growth and transplantation of a custom vascularised bone graft in a man. Lancet 364: 766-770.
37. Xie Y, Chopin D, Morin C, et al. 2006; Evaluation of the osteogenesis and biodegradation of porous biphasic ceramic in the human spine. Biomaterials 27: 2761-2767.