Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 8, 2013, Pages 1457-1465

  Oppici, Elisa ^a   Fodor, Krisztian ^b,d   Paiardini, Alessandro ^c   Williams, Chris ^b,e   Voltattorni, Carla Borri ^a   Wilmanns, Matthias ^b   Cellini, Barbara ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^e UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Alanine:glyoxylate aminotransferase; Crystal structure; Molecular modeling; Pathogenic variant; Primary Hyperoxaluria Type I; Pyridoxal 5 phosphate

Indexed keywords

ALANINE; ALANINE GLYOXYLATE AMINOTRANSFERASE;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; COENZYME; COMPETITIVE INHIBITION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HUMAN; LIVER; MICROENVIRONMENT; MOLECULAR MODEL; MUTATION; OXALOSIS 1; PEROXISOMAL TARGETING SIGNAL; PRIORITY JOURNAL; TRANSAMINATION;

ALANINE:GLYOXYLATE AMINOTRANSFERASE; CRYSTAL STRUCTURE; MOLECULAR MODELING; PATHOGENIC VARIANT; PRIMARY HYPEROXALURIA TYPE I; PYRIDOXAL 5′-PHOSPHATE;

ALANINE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYPEROXALURIA, PRIMARY; LIVER; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; TRANSAMINASES;

EID: 84880700894     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24300     Document Type: Article

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