NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma

Urologic Oncology: Seminars and Original Investigations

Volumn 31, Issue 6, 2013, Pages 938-948

  Liu, Shangwen ^a   Ma, Xin ^a   Ai, Qing ^a   Huang, Qingbo ^a   Shi, Taoping ^a   Zhu, Mingyang ^a   Wang, Baojun ^a   Zhang, Xu ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TRANSCRIPTION FACTOR HES 1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

CLEAR CELL RENAL CELL CARCINOMA; NOTCH1 SIGNALING; PI3K/AKT PATHWAY; PTEN;

AGED; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY NEOPLASMS; MIDDLE AGED; ONCOGENES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, NOTCH1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84880699835     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2011.07.006     Document Type: Article

References (23)

1. Zbar B., Klausner R., Linehan W.M. Studying cancer families to identify kidney cancer genes. Annu Rev Med 2003, 54: 217-233.
2. Escudier B., Eisen T., Stadler W.M., et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356: 125-134.
3. Motzer R.J., Hutson T.E., Tomczak P., et al. Sunitinib vs. interferon-&;α in metastatic renal-cell carcinoma. N Engl J Med 2007, 356: 115-124.
4. Hansson E.M., Lendahl U., Chapman G. NOTCH signaling in development and disease. Semin Cancer Biol 2004, 14: 320-328.
5. Miele L., Golde T., Osborne B. NOTCH signaling in cancer. Curr Mol Med 2006, 6: 905-918.
6. Chen L., Al-Awqati Q. Segmental expression of NOTCH and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol 2005, 288: F939-F952.
7. Yu J., McMahon A.P., Valerius M.T. Recent genetic studies of mouse kidney development. Curr Opin Genet Dev 2004, 14: 550-557.
8. Linehan W.M., Zbar B. Focus on kidney cancer. Cancer Cell 2004, 6: 223-228.
9. Velickovic M., Delahunt B., McIver B., et al. Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis. Mod Pathol 2002, 15: 479-485.
10. Palomero T., Dominguez M., Ferrando A.A. The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia. Cell Cycle 2008, 7: 965-970.
11. Sjolund J., Johansson M., Manna S., et al. Suppression of renal cell carcinoma growth by inhibition of NOTCH signaling in vitro and in vivo. J Clin Invest 2008, 118: 217-228.
12. Jung M., Ramankulov A., Roigas J., et al. In search of suitable reference genes for gene expression studies of human renal cell carcinoma by real-time PCR. BMC Mol Biol 2007, 8: 47.
13. Aster J.C., Pear W.S., Blacklow S.C. NOTCH signaling in leukemia. Annu Rev Pathol 2008, 3: 587-613.
14. Fresno Vara J.A., Casado E., de Castro J., et al. PI3K/Akt signaling pathway and cancer. Cancer Treat Rev 2004, 30: 193-204.
15. Sourbier C., Lindner V., Lang H., et al. The Phosphoinositide 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy. Cancer Res 2006, 66: 5130-5142.
16. Sarbassov D.D., Guertin D.A., Ali S.M., et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307: 1098-1101.
17. Cully M., You H., Levine A.J., et al. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006, 6: 184-192.
18. Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005, 8: 179-183.
19. Kondo K., Yao M., Kobayashi K., et al. PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines. Int J Cancer 2001, 91: 219-224.
20. Shin Lee J., Seok Kim H., Bok Kim Y., et al. Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth. J Surg Oncol 2003, 84: 166-172.
21. Ciofani M., Zuniga-Pflucker J.C. NOTCH promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol 2005, 6: 881-888.
22. Shi W., Harris A.L. NOTCH signaling in breast cancer and tumor angiogenesis: Cross-talk and therapeutic potentials. J Mammary Gland Boil Neoplasia 2006, 11: 41-52.
23. Wu F., Stutzman A., Mo Y.Y. NOTCH signaling and its role in breast cancer. Front Biosci 2007, 12: 4370-4383.