Intravenous fat emulsion to reverse haemodynamic instability from intentional amitriptyline overdose

Resuscitation

Volumn 81, Issue 8, 2010, Pages 1037-1039

  Engels, Paul T ^a,b   Davidow, Jonathan S ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ROYAL ALEXANDRA HOSPITAL   (Canada)

Author keywords

Antidote; Lipid emulsion; Overdose; TCA

Indexed keywords

ADRENALIN; AMITRIPTYLINE; BICARBONATE; INTRALIPID; LIPID EMULSION; MIDAZOLAM; NORADRENALIN; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; CASE REPORT; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG OVERDOSE; DRUG URINE LEVEL; DRUG WITHDRAWAL; EMULSION; ENDOTRACHEAL INTUBATION; GLASGOW COMA SCALE; HEART ARREST; HEART VENTRICLE TACHYCARDIA; HUMAN; INGESTION; INTENSIVE CARE UNIT; MALE; PRIORITY JOURNAL; RESUSCITATION; TONIC CLONIC SEIZURE; TREATMENT OUTCOME; CHEMICALLY INDUCED; DRUG EFFECTS; FOLLOW UP; HEMODYNAMICS; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

ADULT; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CARDIOPULMONARY RESUSCITATION; FAT EMULSIONS, INTRAVENOUS; FOLLOW-UP STUDIES; HEART ARREST; HEMODYNAMICS; HUMANS; MALE; OVERDOSE; DRUG OVERDOSE;

EID: 77954757652     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2010.04.009     Document Type: Article

References (12)

1. Hutchinson M.D., Traub S.J. Tricyclic antidepressant poisoning 2009, September, Uptodate. Retrevied from http://www.uptodate.com.
2. Jamaty C., Bailey B., Larocque A., et al. Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies. Clin Toxicol 2010, 48:1-27.
3. Turner-Lawrence D.E., Kerns W. Intravenous fat emulsion: a potential novel antidote. Toxicol Rev J Med Toxicol 2008, 4.
4. Rosenblatt M.A., Abel M., Fischer G.W., Itzkovich C.J., Eisenkraft J.B. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006, 105:217-218.
5. LipidRegistry. Guy Weinberg. Accessed March 1st, 2010. http://www.lipidregistry.org/.
6. LipidRescue. Guy Weinberg. Accessed March 1st, 2010. http://www.lipidrescue.org/.
7. Sirianni A.J., Osterhoudt K.C., Calello D.P., et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2008, 51:412-415.
8. Finn S.D.H., Uncles D.R., Willers J., et al. Early treatment of a quetiapine and sertraline overdose with intralipid. Anesthesia 2009, 64:191-194.
9. Young A.C., Velez L.I., Kleinschmidt K.C. Intravenous fat emulsion therapy for the intentional sustained-release verapamil overdose. Resuscitation 2009, 80:591-593.
10. Yoav G., Odelia G., Shaltiel C., et al. A lipid emulsion reduces mortality from clomipramine overdose in rats. Vet Hum Toxicol 2002, 44:30.
11. Harvey M., Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med 2007, 49:178-185.
12. Minton N.A., Goode A.G., Henry J.A. The effect of a lipid suspension on amitriptyline disposition. Arch Toxicol 1987, 60:467-469.