-
1
-
-
77952061202
-
Towards a genetic definition of cancer-associated inflammation: role of the IDO pathway
-
Prendergast GC, Metz R, Muller AJ. Towards a genetic definition of cancer-associated inflammation: role of the IDO pathway. Am J Pathol 2010; 176:2082- 7; PMID:20228228; http://dx.doi.org/10.2353/ajpath.2010.091173.
-
(2010)
Am J Pathol
, vol.176
, pp. 2082-2087
-
-
Prendergast, G.C.1
Metz, R.2
Muller, A.J.3
-
2
-
-
46249124461
-
Immune escape as a fundamental trait of cancer: focus on IDO
-
Prendergast GC. Immune escape as a fundamental trait of cancer: focus on IDO. Oncogene 2008; 27:3889- 900; PMID:18317452; http://dx.doi.org/10.1038/onc.2008.35.
-
(2008)
Oncogene
, vol.27
, pp. 3889-3900
-
-
Prendergast, G.C.1
-
3
-
-
84866242667
-
IDO is a nodal pathogenic driver of lung cancer and metastasis development
-
Smith C, Chang MY, Parker KH, Beury DW, Duhadaway JB, Flick HE, et al. IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov 2012; 2:722-35; PMID:22822050; http://dx.doi.org/10.1158/2159-8290.CD-12-0014.
-
(2012)
Cancer Discov
, vol.2
, pp. 722-735
-
-
Smith, C.1
Chang, M.Y.2
Parker, K.H.3
Beury, D.W.4
Duhadaway, J.B.5
Flick, H.E.6
-
4
-
-
79955008449
-
Physiologic control of the functional status of Foxp3+ regulatory T cells
-
Mellor AL, Munn DH. Physiologic control of the functional status of Foxp3+ regulatory T cells. J Immunol 2011; 186:4535-40; PMID:21464094; http://dx.doi.org/10.4049/jimmunol.1002937.
-
(2011)
J Immunol
, vol.186
, pp. 4535-4540
-
-
Mellor, A.L.1
Munn, D.H.2
-
5
-
-
55949117914
-
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase
-
rd, et al. Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc Natl Acad Sci U S A 2008; 105:17073-8; PMID:18952840; http://dx.doi.org/10.1073/pnas.0806173105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17073-17078
-
-
Muller, A.J.1
Sharma, M.D.2
Chandler, P.R.3
Duhadaway, J.B.4
Everhart, M.E.5
Johnson III, B.A.6
-
6
-
-
33846689594
-
Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses
-
Hou DY, Muller AJ, Sharma MD, DuHadaway J, Banerjee T, Johnson M, et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res 2007; 67:792-801; PMID:17234791; http://dx.doi.org/10.1158/0008-5472.CAN-06-2925.
-
(2007)
Cancer Res
, vol.67
, pp. 792-801
-
-
Hou, D.Y.1
Muller, A.J.2
Sharma, M.D.3
DuHadaway, J.4
Banerjee, T.5
Johnson, M.6
-
7
-
-
19344377474
-
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
-
Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron D, et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 2005; 22:633-42; PMID:15894280; http://dx.doi.org/10.1016/j.immuni.2005.03.013.
-
(2005)
Immunity
, vol.22
, pp. 633-642
-
-
Munn, D.H.1
Sharma, M.D.2
Baban, B.3
Harding, H.P.4
Zhang, Y.5
Ron, D.6
-
8
-
-
66749107425
-
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response
-
Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science 2009; 324:1334- 8; PMID:19498172; http://dx.doi.org/10.1126/science.1172638.
-
(2009)
Science
, vol.324
, pp. 1334-1338
-
-
Sundrud, M.S.1
Koralov, S.B.2
Feuerer, M.3
Calado, D.P.4
Kozhaya, A.E.5
Rhule-Smith, A.6
-
9
-
-
84862908818
-
AMPK and mTOR in cellular energy homeostasis and drug targets
-
Inoki K, Kim J, Guan KL. AMPK and mTOR in cellular energy homeostasis and drug targets. Annu Rev Pharmacol Toxicol 2012; 52:381-400; PMID:22017684; http://dx.doi.org/10.1146/annurevpharmtox-010611-134537.
-
(2012)
Annu Rev Pharmacol Toxicol
, vol.52
, pp. 381-400
-
-
Inoki, K.1
Kim, J.2
Guan, K.L.3
-
10
-
-
80054953932
-
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells
-
Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, et al. The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nat Immunol 2011; 12:1113-8; PMID:21983831; http://dx.doi.org/10.1038/ni.2121.
-
(2011)
Nat Immunol
, vol.12
, pp. 1113-1118
-
-
Chuang, H.C.1
Lan, J.L.2
Chen, D.Y.3
Yang, C.Y.4
Chen, Y.M.5
Li, J.P.6
-
11
-
-
77958039494
-
Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion
-
Muller AJ, DuHadaway JB, Chang MY, Ramalingam A, Sutanto-Ward E, Boulden J, et al. Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion. Cancer Immunol Immunother 2010; 59:1655-63; PMID:20640572; http://dx.doi.org/10.1007/s00262-010-0891-4.
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 1655-1663
-
-
Muller, A.J.1
DuHadaway, J.B.2
Chang, M.Y.3
Ramalingam, A.4
Sutanto-Ward, E.5
Boulden, J.6
-
12
-
-
64949113986
-
Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target
-
discussion 787-9
-
Witkiewicz AK, Costantino CL, Metz R, Muller AJ, Prendergast GC, Yeo CJ, et al. Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg 2009; 208:781- 7, discussion 787-9; PMID:19476837; http://dx.doi.org/10.1016/j.jamcollsurg.2008.12.018.
-
(2009)
J Am Coll Surg
, vol.208
, pp. 781-787
-
-
Witkiewicz, A.K.1
Costantino, C.L.2
Metz, R.3
Muller, A.J.4
Prendergast, G.C.5
Yeo, C.J.6
-
13
-
-
80054041992
-
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
-
Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 2011; 478:197-203; PMID:21976023; http://dx.doi.org/10.1038/nature10491.
-
(2011)
Nature
, vol.478
, pp. 197-203
-
-
Opitz, C.A.1
Litzenburger, U.M.2
Sahm, F.3
Ott, M.4
Tritschler, I.5
Trump, S.6
-
14
-
-
16244408626
-
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
-
Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med 2005; 11:312-9; PMID:15711557; http://dx.doi.org/10.1038/nm1196.
-
(2005)
Nat Med
, vol.11
, pp. 312-319
-
-
Muller, A.J.1
DuHadaway, J.B.2
Donover, P.S.3
Sutanto-Ward, E.4
Prendergast, G.C.5
-
15
-
-
34547643025
-
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
-
Metz R, Duhadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, Prendergast GC. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res 2007; 67:7082-7; PMID:17671174; http://dx.doi.org/10.1158/0008-5472.CAN-07-1872.
-
(2007)
Cancer Res
, vol.67
, pp. 7082-7087
-
-
Metz, R.1
Duhadaway, J.B.2
Kamasani, U.3
Laury-Kleintop, L.4
Muller, A.J.5
Prendergast, G.C.6
-
16
-
-
77952051391
-
Overcoming tumor antigen anergy in human malignancies using the novel indeolamine 2,3-dioxygenase (IDO) enzyme inhibitor, 1-methyl-D-tryptophan (1MT)
-
Soliman HH, Antonia S, Sullivan D, Vahanian N, Link C. Overcoming tumor antigen anergy in human malignancies using the novel indeolamine 2,3-dioxygenase (IDO) enzyme inhibitor, 1-methyl-D-tryptophan (1MT). J Clin Oncol 2009; 27:15s.
-
(2009)
J Clin Oncol
, vol.27
-
-
Soliman, H.H.1
Antonia, S.2
Sullivan, D.3
Vahanian, N.4
Link, C.5
-
17
-
-
84055184913
-
Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase
-
Chang MY, Smith C, Duhadaway JB, Pyle JR, Boulden J, Peralta Soler A, et al. Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase. Cancer Biol Ther 2011; 12:12; PMID:22157149.
-
(2011)
Cancer Biol Ther
, vol.12
, pp. 12
-
-
Chang, M.Y.1
Smith, C.2
Duhadaway, J.B.3
Pyle, J.R.4
Boulden, J.5
Soler, A.P.6
-
18
-
-
77952755857
-
Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast
-
Staschke KA, Dey S, Zaborske JM, Palam LR, McClintick JN, Pan T, et al. Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem 2010; 285:16893-911; PMID:20233714; http://dx.doi.org/10.1074/jbc.M110.121947.
-
(2010)
J Biol Chem
, vol.285
, pp. 16893-16911
-
-
Staschke, K.A.1
Dey, S.2
Zaborske, J.M.3
Palam, L.R.4
McClintick, J.N.5
Pan, T.6
-
19
-
-
72249111299
-
mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat
-
Chotechuang N, Azzout-Marniche D, Bos C, Chaumontet C, Gausserès N, Steiler T, et al. mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat. Am J Physiol Endocrinol Metab 2009; 297:E1313-23; PMID:19738034; http://dx.doi.org/10.1152/ajpendo.91000.2008.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
-
-
Chotechuang, N.1
Azzout-Marniche, D.2
Bos, C.3
Chaumontet, C.4
Gausserès, N.5
Steiler, T.6
-
20
-
-
77953414533
-
Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4
-
Cherkasova V, Qiu H, Hinnebusch AG. Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4. Mol Cell Biol 2010; 30:2862-73; PMID:20404097; http://dx.doi.org/10.1128/MCB.00183-10.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 2862-2873
-
-
Cherkasova, V.1
Qiu, H.2
Hinnebusch, A.G.3
-
21
-
-
79952374033
-
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
-
Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, et al. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes 2011; 60:746-56; PMID:21282364; http://dx.doi.org/10.2337/db10-1246.
-
(2011)
Diabetes
, vol.60
, pp. 746-756
-
-
Xiao, F.1
Huang, Z.2
Li, H.3
Yu, J.4
Wang, C.5
Chen, S.6
-
22
-
-
79953176017
-
Signalling by amino acid nutrients
-
Yan L, Lamb RF. Signalling by amino acid nutrients. Biochem Soc Trans 2011; 39:443-5; PMID:21428916; http://dx.doi.org/10.1042/BST0390443.
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 443-445
-
-
Yan, L.1
Lamb, R.F.2
-
23
-
-
34147141941
-
A MAP4 kinase related to Ste20 is a nutrientsensitive regulator of mTOR signalling
-
Findlay GM, Yan L, Procter J, Mieulet V, Lamb RFA. A MAP4 kinase related to Ste20 is a nutrientsensitive regulator of mTOR signalling. Biochem J 2007; 403:13-20; PMID:17253963; http://dx.doi.org/10.1042/BJ20061881.
-
(2007)
Biochem J
, vol.403
, pp. 13-20
-
-
Findlay, G.M.1
Yan, L.2
Procter, J.3
Mieulet, V.4
Lamb, R.F.A.5
-
24
-
-
79151474047
-
Effect of mini-tyrosyl-tRNA synthetase/minitryptophanyl- tRNA synthetase on ischemic angiogenesis in rats: proliferation and migration of endothelial cells
-
Zeng R, Chen YC, Zeng Z, Liu WQ, Jiang XF, Liu R, et al. Effect of mini-tyrosyl-tRNA synthetase/minitryptophanyl- tRNA synthetase on ischemic angiogenesis in rats: proliferation and migration of endothelial cells. Heart Vessels 2011; 26:69-80; PMID:20963594; http://dx.doi.org/10.1007/s00380-010-0032-1.
-
(2011)
Heart Vessels
, vol.26
, pp. 69-80
-
-
Zeng, R.1
Chen, Y.C.2
Zeng, Z.3
Liu, W.Q.4
Jiang, X.F.5
Liu, R.6
-
25
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, et al. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012; 149:410-24; PMID:22424946; http://dx.doi.org/10.1016/j.cell.2012.02.044.
-
(2012)
Cell
, vol.149
, pp. 410-24
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
-
26
-
-
0142137237
-
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
-
Uyttenhove C, Pilotte L, Théate I, Stroobant V, Colau D, Parmentier N, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003; 9:1269-74; PMID:14502282; http://dx.doi.org/10.1038/nm934.
-
(2003)
Nat Med
, vol.9
, pp. 1269-1274
-
-
Uyttenhove, C.1
Pilotte, L.2
Théate, I.3
Stroobant, V.4
Colau, D.5
Parmentier, N.6
-
27
-
-
78049287331
-
mTOR signalling and metabolic regulation of T cell differentiation
-
Peter C, Waldmann H, Cobbold SP. mTOR signalling and metabolic regulation of T cell differentiation. Curr Opin Immunol 2010; 22:655-61; PMID:20833524; http://dx.doi.org/10.1016/j.coi.2010.08.010.
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 655-661
-
-
Peter, C.1
Waldmann, H.2
Cobbold, S.P.3
-
28
-
-
67349256328
-
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo
-
Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, et al. PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo. Mol Immunol 2009; 46:2071-9; PMID:19356803; http://dx.doi.org/10.1016/j.molimm.2009.02.030.
-
(2009)
Mol Immunol
, vol.46
, pp. 2071-2079
-
-
Gruber, T.1
Hermann-Kleiter, N.2
Pfeifhofer-Obermair, C.3
Lutz-Nicoladoni, C.4
Thuille, N.5
Letschka, T.6
-
29
-
-
54349086262
-
Differential requirement of PKC-theta in the development and function of natural regulatory T cells
-
Gupta S, Manicassamy S, Vasu C, Kumar A, Shang W, Sun Z. Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol 2008; 46:213-24; PMID:18842300; http://dx.doi.org/10.1016/j.molimm.2008.08.275.
-
(2008)
Mol Immunol
, vol.46
, pp. 213-224
-
-
Gupta, S.1
Manicassamy, S.2
Vasu, C.3
Kumar, A.4
Shang, W.5
Sun, Z.6
-
30
-
-
0037081849
-
Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction
-
Liu Y, Graham C, Li A, Fisher RJ, Shaw S. Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction. Biochem J 2002; 361:255-65; PMID:11772397.
-
(2002)
Biochem J
, vol.361
, pp. 255-265
-
-
Liu, Y.1
Graham, C.2
Li, A.3
Fisher, R.J.4
Shaw, S.5
-
31
-
-
84870990555
-
Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation
-
Qian F, Liao J, Villella J, Edwards R, Kalinski P, Lele S, et al. Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation. Cancer Immunol Immunother 2012:PMID:22527253; http://dx.doi.org/10.1007/s00262-012-1265-x.
-
(2012)
Cancer Immunol Immunother
-
-
Qian, F.1
Liao, J.2
Villella, J.3
Edwards, R.4
Kalinski, P.5
Lele, S.6
-
32
-
-
79956302084
-
The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells
-
Opitz CA, Litzenburger UM, Opitz U, Sahm F, Ochs K, Lutz C, et al. The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells. PLoS One 2011; 6:e19823; PMID:21625531; http://dx.doi.org/10.1371/journal.pone.0019823.
-
(2011)
PLoS One
, vol.6
-
-
Opitz, C.A.1
Litzenburger, U.M.2
Opitz, U.3
Sahm, F.4
Ochs, K.5
Lutz, C.6
-
33
-
-
67649432744
-
Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees
-
Löb S, Königsrainer A, Rammensee HG, Opelz G, Terness P. Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?. Nat Rev Cancer 2009; 9:445-52; PMID:19461669; http://dx.doi.org/10.1038/nrc2639.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 445-452
-
-
Löb, S.1
Königsrainer, A.2
Rammensee, H.G.3
Opelz, G.4
Terness, P.5
-
34
-
-
33846057130
-
Calreticulin exposure dictates the immunogenicity of cancer cell death
-
Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007; 13:54-61; PMID:17187072; http://dx.doi.org/10.1038/nm1523.
-
(2007)
Nat Med
, vol.13
, pp. 54-61
-
-
Obeid, M.1
Tesniere, A.2
Ghiringhelli, F.3
Fimia, G.M.4
Apetoh, L.5
Perfettini, J.L.6
-
35
-
-
77951865142
-
D-amino acids trigger biofilm disassembly
-
Kolodkin-Gal I, Romero D, Cao S, Clardy J, Kolter R, Losick R. D-amino acids trigger biofilm disassembly. Science 2010; 328:627-9; PMID:20431016; http://dx.doi.org/10.1126/science.1188628.
-
(2010)
Science
, vol.328
, pp. 627-629
-
-
Kolodkin-Gal, I.1
Romero, D.2
Cao, S.3
Clardy, J.4
Kolter, R.5
Losick, R.6
-
36
-
-
84886943831
-
A perspective on new immune adjuvant principles: reprogramming inflammatory states to permit clearance of cancer cells and other age-associated cellular pathologies
-
In press
-
Prendergast GC, Metz R. A perspective on new immune adjuvant principles: reprogramming inflammatory states to permit clearance of cancer cells and other age-associated cellular pathologies. OncoImmunology 2012; 1: In press.
-
(2012)
OncoImmunology
, vol.1
-
-
Prendergast, G.C.1
Metz, R.2
|