Expression of the ARPC4 Subunit of Human Arp2/3 Severely Affects Mycobacterium tuberculosis Growth and Suppresses Immunogenic Response in Murine Macrophages

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Ghosh, Anamika ^a   Tousif, Sultan ^a,b   Bhattacharya, Debapriya ^a   Samuchiwal, Sachin K ^a   Bhalla, Kuhulika ^a   Tharad, Megha ^a   Kumar, Sushil ^a   Prakash, Prem ^a   Kumar, Purnima ^a   Das, Gobardhan ^a,c   Ranganathan, Anand ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b UNIVERSITY OF CALCUTTA   (India)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN RELATED PROTEIN 2-3 COMPLEX; BACTERIAL PROTEIN; PROTEIN ARPC4; PROTEIN RV1626; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL GROWTH; BACTERIAL SHEDDING; BACTERIAL TRANSLOCATION; DOWN REGULATION; IMMUNE RESPONSE; LYSOSOME; MACROPHAGE; MALE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; TUBERCULOSIS;

ACTIN-RELATED PROTEIN 2-3 COMPLEX; ACTINS; ANIMALS; BACTERIAL PROTEINS; CELL SURVIVAL; CULTURE TECHNIQUES; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; IMMUNE TOLERANCE; MACROPHAGES; MALE; MICE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS;

EID: 84880685091     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069949     Document Type: Article

References (34)

1. Bartzatt R, Cirillo SL, Cirillo JD, (2012) Small molecule hydrazide agents to inhibit growth and proliferation of Mycobacterium tuberculosis. Med Chem 8: 273-280.
2. Haagsma AC, Podasca I, Koul A, Andries K, Guillemont J, et al. (2011) Probing the Interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase. PLoS One 6(8): e23575.
3. Tsantrizos YS, (2008) Peptidomimetic therapeutic agents targeting the protease enzyme of the human immunodeficiency virus and hepatitis C virus. Acc Chem Res 41: 1252-1263.
4. Njoroge FG, Chen KX, Shih NY, Piwinski JJ, (2008) Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection. Acc Chem Res 4: 50-59.
5. Rosenkrands I, King A, Weldingh K, Moniatte M, Moertz E, et al. (2000) Towards the proteome of Mycobacterium tuberculosis. Electrophoresis 21: 3740-3756.
6. Morth JP, Gosmann S, Nowak E, Tucker P, (2005) A novel two-component system found in Mycobacterium tuberculosis. FEBS Lett 579: 4145-4148.
7. Tyagi JS, Sharma D, (2004) Signal transduction systems of mycobacteria with special reference to Mtb. Curr Sci 86: 93-102.
8. Haydel SE, Clark-Curtiss JE, (2004) Global expression analysis of two-component system regulator genes during Mycobacterium tuberculosis growth in human macrophages. FEMS Microbiol Lett 236: 341-347.
9. Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, (2004) The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis. Structure 12: 1595-1605.
10. Sassetti CM, Boyd DH, Rubin EJ, (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48: 77-84.
11. Sable SB, Kumar R, Kalra M, Verma I, Khuller GK, et al. (2005) Peripheral blood and pleural fluid mononuclear cell responses to low-molecular-mass secretory polypeptides of Mycobacterium tuberculosis in human models of immunity to tuberculosis. Infect Immun 73: 3547-3558.
12. Covert BA, Spencer JS, Orme IM, Belisle JT, (2001) The application of proteomics in defining the T-cell antigens of Mycobacterium tuberculosis. Proteomics 1: 574-586.
13. Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ, (2008) Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science 281: 105-108.
14. Goldberg M, Theriott J, (1995) Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility. Proc Natl Acad Sci USA 92: 6572-6576.
15. Gouin E, Egile C, Dehoux P, Villiers V, Adams J, et al. (2004) The RickA protein of Rickettsia conorii activates the Arp2/3 complex. Nature 427: 457-461.
16. Rao A, Ram G, Saini AK, Vohra R, Kumar K, et al. (2007) Synthesis and selection of de novo proteins that bind and impede cellular functions of an essential mycobacterial protein. Appl Environ Microbiol 73: 1320-1331.
17. Miller JH (1972) Experiments in molecular genetics. Cold spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. Li J, Smith G, Walker J, (1999) Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc Natl Acad Sci USA 96: 7821-7826.
19. Errico M, Parlanti E, Teson M, de Jesus BMB, Degan P, (2006) New functions of XPC in the protection of human skin cells from oxidative damage. EMBO J 25: 4305-4315.
20. Kumar K, Tharad M, Ganapathy S, Ram G, Narayan A, et al. (2009) Phenyalanine-rich peptides potently bind ESAT6, a virulence determinant of Mycobacterium tuberculosis, and concurrently affect the pathogen's growth. PLoS ONE 4(11): e7615.
21. Schwebach JR, Jacobs WR Jr, Casadevall A, (2001) Sterilization of Mycobacterium tuberculosis Erdman samples by antimicrobial fixation in a biosafety level 3 laboratory. J Clin Microbiol 39: 769-771.
22. Schmittgen TD, Livak KJ, (2008) Analyzing real-time PCR data by the comparative Ct method. Nat Protoc 6: 1101-1108.
23. Renshaw PS, Lightbody KL, Veverka V, Muskett FW, Kelly J, et al. (2005) Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J 24: 2491-2498.
24. Vaynberg J, Qin J, (2006) Weak protein-protein interactions as probed by NMR spectroscopy. Trends Biotechnol 24: 22-27.
25. Malm S, Tiffert Y, Micklinghoff J, Schultze S, Joost I, et al. (2009) The roles of the nitrate reductase NarGHJI, the nitrite reductase NirBD and the response regulator GlnR in nitrate assimilation of Mycobacterium tuberculosis. Microbiology 155: 1332-1339.
26. McCann JR, McDonough JA, Sullivan JT, Feltcher ME, Braunstein M, (2011) Genome-wide identification of Mycobacterium tuberculosis exported proteins with roles in intracellular growth. J Bacteriol 193: 854-861.
27. Pollard TD, Beltzner CC, (2002) Structure and function of the Arp2/3 complex. Curr Opin Struct Biol 12: 768-774.
28. Rhoardes ER, Ullrich HJ, (2000) How to establish a lasting relationship with your host: Lessons learned from Mycobacterium spp. Immunol Cell Biol 78: 301-310.
29. Stamm L, Morisaki J, Gao L, Jeng R, McDonald KL, et al. (2003) Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. J Exp Med 198: 1361-1368.
30. Stamm L, Pak M, Morisaki J, Snapper S, Rottner K, et al. (2005) Role of the WASP family proteins for Mycobacterium marinum actin tail formation. Proc Natl Acad Sci USA 102: 14837-14842.
31. McDonough K, Kress Y, Bloom B, (1993) Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages. Infect Immun 61: 2763-2773.
32. Van der Wel N, Hava D, Houben D, Fluitsma D, van Zon M, et al. (2007) M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 129: 1287-1298.
33. Myrvik QA, Leake ES, Wright MJ, (1984) Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. Am Rev Respir Dis 129: 322-328.
34. Hagedorn M, Rohde K, Russell D, Soldati T, (2009) Infection by tubercular mycobacteria is spread by nonlytic injection from their amoeba hosts. Science 323: 1729-1733.