Role of klebsiella pneumoniae type 1 and type 3 fimbriae in colonizing silicone tubes implanted into the bladders of mice as a model of catheter-associated urinary tract infections

Infection and Immunity

Volumn 81, Issue 8, 2013, Pages 3009-3017

  Murphy, Caitlin N ^a   Mortensen, Martin S ^b   Krogfelt, Karen A ^b   Clegg, Steven ^a  

^a UNIVERSITY OF IOWA   (United States)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIAL LOAD; BACTERIAL VIRULENCE; BACTERIUM MUTANT; BIOFILM; BLADDER; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; FIMBRIA; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; LIMIT OF DETECTION; MIXED INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SILASTIC TUBE; URINARY CATHETER; URINARY TRACT INFECTION;

ANIMALS; BIOFILMS; CATHETER-RELATED INFECTIONS; DISEASE MODELS, ANIMAL; FEMALE; FIMBRIAE, BACTERIAL; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICE; MICE, INBRED C57BL; SILICONES; URINARY TRACT INFECTIONS;

EID: 84880663296     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00348-13     Document Type: Article

References (39)

1. Frank DN, Wilson SS, St Amand AL, Pace NR. 2009. Culture-independent microbiological analysis of Foley urinary catheter biofilms. PLoS One 4:e7811. doi :10.1371/journal.pone.0007811.
2. Ronald A. 2002. The etiology of urinary tract infection: traditional and emerging pathogens. Am. J. Med. 113(Suppl 1A):14S-19S.
3. Livrelli V, De Champs C, Di Martino P, Darfeuille-Michaud A, Fores-tier C, Joly B. 1996. Adhesive properties and antibiotic resistance of Klebsiella, Enterobacter, and Serratia clinical isolates involved in nosocomial infections. J. Clin. Microbiol. 34:1963-1969.
4. Klemm P, Schembri MA. 2000. Bacterial adhesins: function and structure. Int. J. Med. Microbiol. 290:27-35.
5. Kline KA, Dodson KW, Caparon MG, Hultgren SJ. 2010. A tale of two pili: assembly and function of pili in bacteria. Trends Microbiol. 18:224-232.
6. Rosen DA, Pinkner JS, Jones JM, Walker JN, Clegg S, Hultgren SJ. 2008. Utilizationof an intracellular bacterial community pathwayinKleb-siella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infect. Immun. 76:3337-3345.
7. Struve C, Bojer M, Krogfelt KA. 2008. Characterization of Klebsiella pneumoniae type 1 fimbriae by detection of phase variation during colonization and infection and impact on virulence. Infect. Immun. 76:4055-4065.
8. Connell I, Agace W, Klemm P, Schembri M, Marild S, Svanborg C. 1996. Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract. Proc. Natl. Acad. Sci. U. S. A. 93:9827-9832.
9. Duguid JP. 1959. Fimbriae and adhesive properties in Klebsiella strains. J. Gen. Microbiol. 21:271-286.
10. Burmolle M, Bahl MI, Jensen LB, Sorensen SJ, Hansen LH. 2008. Type 3 fimbriae, encoded by the conjugative plasmid pOLA52, enhance biofilm formation and transfer frequencies in Enterobacteriaceae strains. Microbiology 154:187-195.
11. Ong CL, Ulett GC, Mabbett AN, Beatson SA, Webb RI, Monaghan W, Nimmo GR, Looke DF, McEwan AG, Schembri MA. 2008. Identification of type 3 fimbriae in uropathogenic Escherichia coli reveals a role in bio-film formation. J. Bacteriol. 190:1054-1063.
12. Ong CL, Beatson SA, Totsika M, Forestier C, McEwan AG, Schembri MA. 2010. Molecular analysis of type 3 fimbrial genes from Escherichia coli, Klebsiella and Citrobacter species. BMC Microbiol. 10:183. doi: 10.1186/1471-2180-10-183.
13. Di Martino P, Cafferini N, Joly B, Darfeuille-Michaud A. 2003. Kleb-siella pneumoniae type 3 pili facilitate adherence and biofilm formation on abiotic surfaces. Res. Microbiol. 154:9-16.
14. Boddicker JD, Anderson RA, Jagnow J, Clegg S. 2006. Signature-tagged mutagenesis of Klebsiella pneumoniae to identify genes that influence biofilm formation on extracellular matrix material. Infect. Immun. 74: 4590-4597.
15. Lavender HF, Jagnow JR, Clegg S. 2004. Biofilm formation in vitro and virulence in vivo of mutants of Klebsiella pneumoniae. Infect. Immun. 72:4888-4890.
16. Jagnow J, Clegg S. 2003. Klebsiella pneumoniae MrkD-mediated biofilm formation on extracellular matrix- and collagen-coated surfaces. Microbiology 149:2397-2405.
17. Langstraat J, Bohse M, Clegg S. 2001. Type 3 fimbrial shaft (MrkA) of Klebsiella pneumoniae, but not the fimbrial adhesin (MrkD), facilitates biofilm formation. Infect. Immun. 69:5805-5812.
18. Schroll C, Barken KB, Krogfelt KA, Struve C. 2010. Role of type 1 and type 3 fimbriae in Klebsiella pneumoniae biofilm formation. BMC Micro-biol. 10:179. doi: 10.1186/1471-2180-10-179.
19. Sebghati TA, Korhonen TK, Hornick DB, Clegg S. 1998. Characterization of the type 3 fimbrial adhesins of Klebsiella strains. Infect. Immun. 66:2887-2894.
20. Schurtz TA, Hornick DB, Korhonen TK, Clegg S. 1994. The type 3 fimbrial adhesin gene (mrkD) ofKlebsiella speciesisnot conserved among all fimbriate strains. Infect. Immun. 62:4186-4191.
21. Rego AT, Johnson JG, Geibel S, Enguita FJ, Clegg S, Waksman G. 18 September 2012. Crystal structure of the MrkD(1P) receptor binding domain of Klebsiella pneumoniae and identification of the human collagen V binding interface. Mol. Microbiol. [Epub ahead of print.] doi: 10.1111/mmi.12023.
22. Mobley HL, Chippendale GR, Tenney JH, Mayrer AR, Crisp LJ, Penner JL, Warren JW. 1988. MR/K hemagglutination of Providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria. J. Infect. Dis. 157:264-271.
23. Richards MJ, Edwards JR, Culver DH, Gaynes RP. 1999. Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit. Care Med. 27:887-892.
24. Richards MJ, Edwards JR, Culver DH, Gaynes RP. 2000. Nosocomial infectionsin combined medical-surgical intensive care units in the United States. Infect. Control Hosp. Epidemiol. 21:510-515.
25. Guiton PS, Hung CS, Hancock LE, Caparon MG, Hultgren SJ. 2010. Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections. Infect. Immun. 78:4166-4175.
26. Guiton PS, Hannan TJ, Ford B, Caparon MG, Hultgren SJ. 2013. Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. Infect. Immun. 81:329-339.
27. Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ. 2012. Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrob. Agents Che-mother. 56:4738-4745.
28. Struve C, Bojer M, Krogfelt KA. 2009. Identification of a conserved chromosomal region encoding Klebsiella pneumoniae type 1 and type 3 fimbriae and assessment of the role of fimbriae in pathogenicity. Infect. Immun. 77:5016-5024.
29. Datsenko KA, Wanner BL. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. U. S. A. 97:6640-6645.
30. Duguid JP, Campbell I. 1969. Antigens of the type-1 fimbriae of salmo-nellae and other enterobacteria. J. Med. Microbiol. 2:535-553.
31. El Fertas-Aissani R, Messai Y, Alouache S, Bakour R. 5 December 2012. Virulence profiles and antibiotic susceptibility patternsofKlebsiella pneumoniae strains isolated from different clinical specimens. Pathol. Biol. [Epub ahead of print.] doi :10.1016/j.patbio.2012.10.004.
32. Hornick DB, Allen BL, Horn MA, Clegg S. 1991. Fimbrial types among respiratory isolates belonging to the family Enterobacteriaceae. J. Clin. Microbiol. 29:1795-1800.
33. Francois P, Vaudaux P, Foster TJ, Lew DP. 1996. Host-bacteria interactions in foreign body infections. Infect. Control Hosp. Epidemiol. 17: 514-520.
34. Dickinson GM, Bisno AL. 1989. Infections associated with indwelling devices: concepts of pathogenesis; infections associated with intravascular devices. Antimicrob. Agents Chemother. 33:597-601.
35. Stahlhut SG, Struve C, Krogfelt KA, Reisner A. 2012. Biofilm formation of Klebsiella pneumoniae on urethral catheters requires either type 1 or type 3 fimbriae. FEMS Immunol. Med. Microbiol. 65:350-359.
36. Clegg S, Wilson J, Johnson J. 2011. More than one way to control hair growth: regulatory mechanisms in enterobacteria that affect fimbriae assembled by the chaperone/usher pathway. J. Bacteriol. 193:2081-2088.
37. Murphy CN, Clegg S. 2012. Klebsiella pneumoniae and type 3 fimbriae: nosocomial infection, regulation and biofilm formation. Future Micro-biol. 7:991-1002.
38. Wu CC, Huang YJ, Fung CP, Peng HL. 2010. Regulation of the Klebsiella pneumoniae Kpc fimbriae by the site-specific recombinase KpcI. Microbiology 156:1983-1992.
39. Eden CS, Eriksson B, Hanson LA. 1977. Adhesion of Escherichia coli to human uroepithelial cells in vitro. Infect. Immun. 18:767-774.