Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor

International Journal of Oncology

Volumn 43, Issue 3, 2013, Pages 737-745

  Takaoka, Kazuki ^a   Hidaka, Sayaka ^a   Hashitani, Susumu ^a   Segawa, Emi ^a   Yamamura, Michiyo ^a   Tanaka, Noriaki ^b   Zushi, Yusuke ^a   Noguchi, Kazuma ^a   Kishimoto, Hiromitsu ^a   Urade, Masahiro ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Adenoid cystic carcinoma; Chemokine receptor 4 antagonist; Metastasis; Nitric oxide synthase inhibitor; Oral floor; Tumor growth

Indexed keywords

N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) NITROARGININE METHYL ESTER; PLERIXAFOR;

ADENOID CYSTIC CARCINOMA; ADENOID CYSTIC CARCINOMA OF THE ORAL FLOOR; AGED; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CANCER INHIBITION; CANCER SURVIVAL; CAPILLARY DENSITY; CONTROLLED STUDY; FEMALE; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LONG TERM SURVIVAL; LUNG METASTASIS; MALE; MOUSE; MOUTH; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TUMOR CELL; TUMOR GROWTH; TUMOR VOLUME; WESTERN BLOTTING; XENOTRANSPLANTATION;

ANIMALS; APOPTOSIS; CARCINOMA, ADENOID CYSTIC; CELL MOVEMENT; ENZYME INHIBITORS; HUMANS; LUNG NEOPLASMS; MICE; MOUTH NEOPLASMS; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECEPTORS, CXCR4; TRANSPLANTATION, HETEROLOGOUS;

EID: 84880636318     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2011     Document Type: Article

References (38)

1. de Kerviler E, Bely N, Laccourreye O, Clement O, Halimi P and Frija G: The aryepiglottic fold as a rare location of adenoid cystic carcinoma. Am J Neuroradiol 16: 1375-1377, 1995.
2. Fordice J, Kershaw C, El-Naggar A and Goepfert H: Adenoid cystic carcinoma of the head and neck. Predictors of morbidity and mortality. Arch Otolaryngol Head Neck Surg 125: 149-152, 1999.
3. Nathan C and Xie QW: Nitric oxide synthases: roles, tolls and controls. Cell 78: 915-918, 1994.
4. Fukumura D, Kashiwagi S and Jain RK: The role of nitric oxide in tumor progression. Nat Rev Cancer 6: 521-534, 2006.
5. Beckman JS, Beckman YW, Chen J, Marshall PA and Freeman BA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric and superoxide. Proc Natl Acad Sci USA 87: 1620-1624, 1990.
6. Prueitt RL, Boersma BJ, Howe TM, et al: Inflammation and IGF-1 activate the Akt pathway in breast cancer. Int J Cancer 120: 796-805, 2007.
7. Ekmekcioglu S, Ellerhorst J, Prieto VG, et al: Tumor iNOS predicts poor survival for stage III melanoma patients. Int J Cancer 119: 861-866, 2006.
8. Ying L and Hofseth LJ: An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer. Cancer Res 67: 1407-1410, 2007.
9. Ohtsu N, Takaoka K, Segawa E, et al: Antitumor effect of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. Oncol Rep 24: 31-36, 2010.
10. Muller A, Homey B, Soto H, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001.
11. Pablos JL, Amara A, Bouloc A, et al: Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin. Am J Pathol 155: 1577-1586, 1999.
12. Aiuti A, Webb IJ, Bleul C, Springer T and Gutierrez-Ramos JC: The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 185: 111-120, 1997.
13. Tashiro K, Tada H, Heilker R, Shirozu M, Nakano T and Honjo T: Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science 261: 600-603, 1999.
14. Bleul CC, Fuhlbrigge RC, Cassasnovas JM, Aiuti A and Springer TA: A high efficacious lymphocyte chemoattractant, stromal cell-derived factor-1α (SDF-1α). J Exp Med 184: 1101-1109, 1996.
15. Campbell JJ, Hedrick J, Zlotnik A, Siani MA, Thompson DA and Butcher EC: Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 279: 381-384, 1998.
16. Grabovsky V, Feigelson S, Chen C, et al: Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions. J Exp Med 192: 495-506, 2000.
17. Wright N, Hidalgo A, Rodriguez-Frade JM, et al: The chemokine stromal cell-derived factor-1α modulates α4β7 integrin-mediated lymphocytes adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin. J Immunol 168: 5268-5277, 2002.
18. Ganju RK, Brubaker SA, Meyer J, et al: The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem 273: 23169-23175, 1998.
19. Homey B, Muller A and Zlotnik A: Chemokines: agents for the immunotherapy of cancer? Nat Rev Immunol 2: 175-184, 2002.
20. Cardones AR, Murakami T and Hwang ST: CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via β(1) integrin. Cancer Res 63: 6751-6757, 2003.
21. Murakami T, Maki W, Cardones AR, et al: Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res 62: 7328-7234, 2002.
22. Robledo MM, Bartolome RA, Longo N, et al: Expression of functional chemokine receptor CXCR3 and CXCR4 on human melanona cells. J Biol Chem 276: 45098-45105, 2001.
23. Zushi Y, Noguchi K, Hashitani S, et al: Relations among expression of CXCR4, histological patterns and metastatic potential in adenoid cystic carcinoma of head and neck. Int J Oncol 33: 1133-1139, 2008.
24. Hashitani S, Urade M, Zushi Y, Segawa E, Okui S and Sakurai K: Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung. Oncol Rep 17: 67-72, 2007.
25. Ovejera AA, Houchens DP and Baker AD: Chemotherapy of human tumor xenografts in genetically athymic mice. Ann Clin Lab Sci 8: 50-56, 1978.
26. Hsu SM, Raine L and Franger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29: 577-580, 1981.
27. Gavrieli Y, Sherman Y and Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501, 1992.
28. Ekmekcioglu S, Tang C and Grimm EA: NO news is not necessarily good news in cancer. Curr Cancer Drug Targets 5: 103-115, 2005.
29. Wink DA, Ridnour LA, Hussain SP and Harris CC: The reemergence of nitric oxide and cancer. Nitric Oxide 19: 65-67, 2008.
30. Li G, Yang T and Yan J: Cyclooxygenase-2 increased the angiogenic and metastatic potential of tumor cells. Biochem Biophys Res Commun 299: 886-890, 2002.
31. Engels K, Knauer SK, Loibl S, et al: NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. Cancer Res 68: 5159-5166, 2008.
32. Fetz V, Bier C, Habtemichael N, et al: Inducible NO synthase confers chemoresistance in head and neck cancer by modulating survivin. Int J Cancer 124: 2033-2041, 2009.
33. Roy HK, Wali RK, Kim Y, et al: Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett 581: 3857-3862, 2007.
34. Singh RP and Agarwal R: Inducible nitric oxide synthase-vascular endothelial growth factor axis: a potential target to inhibit tumor angiogenesis by dietary agents. Curr Cancer Drug Targets 7: 475-483, 2007.
35. Nguyen DX, Bos PD and Massague J: Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284, 2009.
36. Joyce JA and Pollard JW: Microenvironmental regulation of metastasis. Nat Rev Cancer 9: 239-252, 2009.
37. Yasuoka H, Kodama R, Hirokawa M, et al: CXCR4 expression in papillary thyroid carcinoma: induction by nitric oxide and correlation with lymph node metastasis. BMC Cancer 8: 274, 2008.
38. Yasuoka H, Tsujimoto M, Yoshidome K, et al: Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis. BMC Cancer 8: 340, 2008.