Napsin A expression in anaplastic, poorly differentiated, and micropapillary pattern thyroid carcinomas

American Journal of Surgical Pathology

Volumn 37, Issue 8, 2013, Pages 1215-1222

  Chernock, Rebecca D ^a   El Mofty, Samir K ^a   Becker, Nils ^a   Lewis, James S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

anaplastic thyroid carcinoma; micropapillary pattern thyroid carcinoma; Napsin A; PAX8; poorly differentiated thyroid carcinoma

Indexed keywords

ASPARTIC PROTEINASE; DNA BINDING PROTEIN; NAPSA PROTEIN, HUMAN; PAIRED BOX TRANSCRIPTION FACTOR; PAX8 PROTEIN, HUMAN; TTF1 PROTEIN, HUMAN; TUMOR MARKER;

ADENOCARCINOMA; ARTICLE; BIOPSY; CELL DIFFERENTIATION; DIFFERENTIAL DIAGNOSIS; ENZYMOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG TUMOR; PAPILLARY CARCINOMA; PAPILLARY THYROID MICROCARCINOMA; PATHOLOGY; PREDICTIVE VALUE; THYROID TUMOR;

ADENOCARCINOMA; ASPARTIC ACID ENDOPEPTIDASES; BIOPSY; CARCINOMA, PAPILLARY; CELL DIFFERENTIATION; DIAGNOSIS, DIFFERENTIAL; DNA-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; PAIRED BOX TRANSCRIPTION FACTORS; PREDICTIVE VALUE OF TESTS; THYROID NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84880572230     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318283b7b2     Document Type: Article

References (24)

1. Chuman Y, Bergman A-C, Ueno T, et al. Napsin A, a member of the aspartic protease family is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. FEBS Lett. 1999;462:129-134
2. Tatnell PJ, Powell DJ, Hill J, et al. Napsins: New human aspartic proteinases distinction betwen two closely related genes. FEBS Lett. 1998;441:43-48
3. Kim MJ, Shin HC, Shin KC, et al. Best immunohistochemical panel in distinguishing adenocarcinoma from squamous cell carcinoma of lung: Tissue microarray assay in resected lung cancer specimens. Ann Diagn Pathol. 2012;17:85-90
4. Tacha D, Yu C, Bremer R, et al. A 6-antibody panel for the classification of lung adenocarcinoma versus squamous cell carcinoma. Appl Immunohistochem Mol Morphol. 2012;20:201-207
5. Ueno T, Linder S, Elmberger G. Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. Br J Cancer. 2003;88:1229-1233
6. Whithaus K, Fukuoka J, Prihoda TJ, et al. Evaluation of Napsin A, cytokeratin 5/6, p63, and thyroid transcription factor 1 in adenocarcinoma versus squamous cell carcinoma of the lung. Arch Pathol Lab Med. 2012;136:155-162
7. Bishop JA, Sharma R, Illei P, et al. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. Hum Pathol. 2010;41:20-25
8. Turner BM, Cagle PT, Sainz IM, et al. Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma. Arch Pathol Lab Med. 2012;136:163-171
9. Ye J, Findeis-Hosey JJ, Yang Q, et al. Combination of Napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung. Appl Immunohistochem Mol Morphol. 2011;19:313-317
10. Kadivar M, Boozari B. Applications and limitations of immunohistochemical expression of "Napsin-A" in distinguishing lung adenocarcinoma from adenocarcinoma of other organs. Appl Immunohistochem Mol Morphol. 2012. [Epub ahead of print].
11. Mukhopadhyay S, Katzenstein AL. Comparison of monoclonal Napsin A, polyclonal Napsin A, and TTF-1 for determining lung origin in metastatic adenocarcinomas. Am J Clin Pathol. 2012;138:703-711
12. Amin M, Ro J, El-Sharkawy T, et al. Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary serous carcinoma. Am J Surg Pathol. 1994;18:1224-1232
13. AminMB, Tamboli P,Merchant SH, et al.Micropapillary component in lung adenocarcinoma: A distinctive histologic feature with possible prognostic significance. Am J Surg Pathol. 2002;26:358-364
14. Bai Y, Kakudo K, Li Y, et al. Subclassification of non-solid-type papillary thyroid carcinoma identification of high-risk group in common type. Cancer Sci. 2008;99:1908-1915
15. Lino-Silva LS, Dominguez-Malagon HR, Caro-Sanchez CH, et al. Thyroid gland papillary carcinomas with "micropapillary pattern," a recently recognized poor prognostic finding: Clinicopathologic and survival analysis of 7 cases. Hum Pathol. 2012;43:1596-1600
16. Miyoshi T, Satoh Y, Okumura S, et al. Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis. Am J Surg Pathol. 2003;27:101-109
17. Motosugi U, Murata S-I, Nagata K, et al. Thyroid papillary carcinoma with micropapillary and hobnail growth pattern: A histologic variant with intermediate malignancy? Thyroid. 2009;19: 535-537
18. Siriaunkgul S, Tavassoli F. Invasive micropapillary carcinoma of the breast. Mod Pathol. 1993;6:660-662
19. Fabbro D, Loreto CD, Beltrami CA, et al. Expression of thyroidspecific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms. Cancer Res. 1994;54:4744-4749
20. Nonaka D, Tang Y, Rivera M, et al. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol. 2008;21:192-200
21. Ye J, Hameed O, Findeis-Hosey J, et al. Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung. Biotech Histochem. 2012;87: 30-34
22. DeLellis RA, Lloyd RV, Heitz PU, et al. Pathology & Genetics Tumors of Endocrine Organs. Lyon: IARC Press; 2004
23. Volante M, Collini P, Nikiforov Y, et al. Poorly differentiated thyroid carcinoma: The Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach. Am J Surg Pathol. 2007;31:1256-1264
24. Laury AR, Perets R, Piao H, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011;35:816-826