A 6-antibody panel for the classification of lung adenocarcinoma versus squamous cell carcinoma

Applied Immunohistochemistry and Molecular Morphology

Volumn 20, Issue 3, 2012, Pages 201-207

  Tacha, David ^a   Yu, Charie ^a   Bremer, Ryan ^a   Qi, Weiman ^a   Haas, Thomas ^b  

^a Biocare Medical   (United States)

^b MERCY HEALTH SYSTEM   (United States)

Author keywords

Desmoglein 3; lung adenocarcinoma; lung squamous cell carcino ma; Napsin A; TRIM29

Indexed keywords

ASPARTIC PROTEINASE; CANCER ANTIBODY; CYTOKERATIN 5; DESMOGLEIN 3 ANTIBODY; NAPSIN A; PROTEIN P63; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR; TRIPARTITE MOTIF PROTEIN 29; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ARTICLE; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CANCER GRADING; CANCER IMMUNOLOGY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY;

ADENOCARCINOMA; ALGORITHMS; ANIMALS; ANTIBODIES; BIOPSY, FINE-NEEDLE; CARCINOMA, SQUAMOUS CELL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MICE; MIDDLE AGED; PARAFFIN EMBEDDING; RABBITS; RECOMBINANT PROTEINS; RESEARCH DESIGN; SENSITIVITY AND SPECIFICITY; TISSUE FIXATION; TUMOR MARKERS, BIOLOGICAL;

EID: 84859924253     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e31823d7f0e     Document Type: Article

References (26)

1. American Cancer Society. Cancer Facts and Figures 2010. Atlanta: American Cancer Society; 2010:4.
2. Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011;35: 15-25.
3. Terry J, Leung S, Laskin J, et al. Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples. Am J Surg Pathol. 2010; 34:1805-1811.
4. Loo PS, Thomas SC, Nicolson MC, et al. Subtyping of undifferentiated non-small cell carcinomas in bronchial biopsy specimens. J Thorac Oncol. 2010;5:442-447.
5. Ring BZ, Seitz RS, Beck RA, et al. A novel five-antibody immunohistochemical test for subclassification of lung carcinoma. Mod Pathol. 2009;22:1032-1043.
6. Khayyata S, Yun S, Pasha T, et al. Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. Diagn Cytopathol. 2009;37: 178-183.
7. Gettinger S. Targeted therapy in advanced non-small-cell lung cancer. Semin Respir Crit Care Med. 2008;29:291-301. (Pubitemid 351748435)
8. Fabbro D, Di Loreto C, Stamerra O, et al. TTF-1 gene expression in human lung tumours. Eur J Cancer. 1996;32A:512-517.
9. Di Loreto C, Di Lauro V, Puglisi F, et al. Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma. J Clin Pathol. 1997;50:30-32. (Pubitemid 27060201)
10. Kaufmann O, Dietel M. Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. Histopathology. 2000;36:8-16. (Pubitemid 30055417)
11. Pelosi G, Pasini F, Olsen Stenholm C, et al. p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas? J Pathol. 2002;198:100-109. (Pubitemid 34966213)
12. Au NH, Gown AM, Cheang M, et al. p63 expression in lung carcinoma: a tissue microarray study of 408 cases. Appl Immunohistochem Mol Morphol. 2004;12:240-247.
13. Jorda M, Gomez-Fernandez C, Garcia M, et al. p63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples: implications in treatment selection. Cancer. 2009;117:46-50.
14. Savci-Heijink CD, Kosari F, Aubry MC, et al. The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung. Am J Pathol. 2009;174:1629-1637.
15. Fukuoka J, Dracheva T, Shih JH, et al. Desmoglein 3 as a prognostic factor in lung cancer. Hum Pathol. 2007;38:276-283. (Pubitemid 46096551)
16. Tacha D, Zhou D, Henshall-Powell RL. Distinguishing adenocarcinoma from squamous cell carcinoma in lung using double stains p63+ CK5 and TTF-1+Napsin A [Abstract]. Mod Pathol. 2010;23(Supplement 1):222A.
17. Tacha D, Yu C, Haas T. TTF-1, Napsin A, p63, TRIM29, Desmoglein 3 and CK5: an evaluation of sensitivity and specificity and correlation of tumor grade for lung cell carcinoma vs. lung adenocarcinoma [Abstract]. Mod Pathol. 2011;24(Supplement 1):425A.
18. Schauer-Vukasinovic V, Bur D, Kling D, et al. Human napsin A: expression, immunochemical detection, and tissue localization. FEBS Lett. 1999;462:135-139.
19. Hirano T, Auer G, Maeda M, et al. Human tissue distribution of TA02, which is homologous with a new type of aspartic proteinase, napsin A. Jpn J Cancer Res. 2000;91:1015-1021.
20. Suzuki A, Shijubo N, Yamada G, et al. Napsin A is useful to distinguish primary lung adenocarcinoma from adenocarcinomas of other organs. Pathol Res Pract. 2005;201:579-586. (Pubitemid 41363952)
21. Berglund L, Björling E, Oksvold P, et al. A gene-centric human protein atlas for expression profiles based on antibodies. Mol Cell Proteomics. 2008;10:2019-2027. MUC1:http://www.proteinatlas.org/ENSG00000185499.
22. Berglund L, Björling E, Oksvold P, et al. A gene-centric human protein atlas for expression profiles based on antibodies. Mol Cell Proteomics. 2008;10:2019-2027. CEACAM5: http://www.proteinatlas.org/ENSG00000105388.
23. Reymond A, Meroni G, Fantozzi A, et al. The tripartite motif family identifies cell compartments. EMBO J. 2001;20:2140-2151. (Pubitemid 32410584)
24. Kosaka Y, Inoue H, Ohmachi T, et al. Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann Surg Oncol. 2007;14:2543-2549. (Pubitemid 47389583)
25. Kargi A, Gurel D, Tuna B. The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas. Appl Immunohistochem Mol Morphol. 2007;15:415-420. (Pubitemid 350307847)
26. Camilo R, Capelozzi VL, Siqueira SA, et al. Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non-small cell lung carcinomas. Hum Pathol. 2006;37:542-546.