Serum-based DNA methylation biomarkers in colorectal cancer: Potential for screening and early detection

Journal of Cancer

Volumn 4, Issue 3, 2013, Pages 210-216

  Summers, Thomas ^a   Langan, Russell C ^b   Nissan, Aviram ^c,d,e   Brücher, Björn L D M ^d,e,l   Bilchik, Anton J ^d,e,f,g   Protic, Mladjan ^d,e,h,i   Daumer, Martin ^e,j   Avital, Itzhak ^d,e,k,l   Stojadinovic, Alexander ^a,d,e,l  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b GEORGETOWN UNIVERSITY HOSPITAL   (United States)

^c RABIN MEDICAL CENTER   (Israel)

^d US Military Cancer Institute   (United States)

^e International Consortium of Research Excellence of the Theodor Billroth Academy   (Germany)

^f California Oncology Research Institute   (United States)

^g JOHN WAYNE CANCER INSTITUTE   (United States)

^h Clinical Center of Vojvodina   (Serbia)

ⁱ UNIVERSITY OF NOVI SAD   (Serbia)

^j Sylvia Lawry Centre   (Germany)

^k Uniformed Services University of the Health Sciences   (United States)

^l Bon Secours Cancer Institute   (United States)

more..

Author keywords

Biomarker; Colorectal cancer; DNA methylation; Early detection; Screening; Serum

Indexed keywords

DNA; TUMOR MARKER;

ARTICLE; CANCER DIAGNOSIS; CANCER PROGNOSIS; CANCER SCREENING; CANCER STAGING; COLORECTAL CANCER; CPG ISLAND; DNA BASE COMPOSITION; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GENE MUTATION; HUMAN; SENSITIVITY AND SPECIFICITY;

EID: 84880516297     PISSN: None     EISSN: 18379664     Source Type: Journal    
DOI: 10.7150/jca.5839     Document Type: Article

References (26)

1. Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA: a cancer journal for clinicians 2011;61:212-36.
2. Heron, M. Deaths: Leading causes for 2009. National Vital Statistics Report 2012;61(7):1-95.
3. Brooks, JD. Translational genomics: The challenge of developing cancer biomarkers. Genome Res 2012;22:183-187.
4. Glass AG, Lacey JV Jr, Carreon JD, Hoover RN. Breast cancer incidence,1980-2006: Combined roles of menopausal hormone therapy,screening mammography, and estrogen receptor status. J Natl Cancer Inst 2007;99:1152-1161.
5. Levin B, Lieberman DA, McFarland B, Andrews KS, Brooks D, Bond J, Dash C, Giardiello FM, Glick S, Johnson D, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: A joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008;134:1570-1595.
6. Schroder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 2009;360:1320-1328.
7. National Lung Screening Trial Research Team, Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011;365:395-409.
8. De Paoli VM, Chen C-H, Chang Y-W. Are DNA methylation markers ready for colorectal cancer detection?. Cancer Biology & Therapy 2010;9(11):872-874.
9. Brücher, BLDM, Geddert H, Langner C, Höfler H, Fink U, Siewert JR, Sarbia M. Hypermethylation of hMLH1, HPP1, p14ARF, p16INK4A, and APC in primary adenocarcinomas of the small bowel. Int J Cancer 2006;119:1298-1302.
10. De Gruttola VG, Clax P, DeMets DL, et al. Considerations in the evaluation of surrogate endpoints in clinical trials. summary of a National Institutes of Health workshop. Controlled clinical trials 2001;22:485-502.
11. Levenson VV. DNA methylation as a universal biomarker. Expert Rev Mol Diagn 2010;10(4):481-488.
12. Laird PW. The power and the promise of DNA methylation markers. Nature Reviews 2003;3:253-266.
13. Leon SA, Shapiro B, Sklaroff DM, and Yaros MJ. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 1977;37:646-650.
14. Matei DE, Nephew KP. Epigenetic therapies for chemoresensitization of epithelial ovarian cancer. Gynecol. Oncol 2010;116:195-201.
15. Levenson VV and Melnikov AA. DNA methylation as clinically useful biomarkers-Light at the end of the tunnel. Pharmaceuticals 2012;5:94-113.
16. Atamaniuk J, Vidotto C, Kinzlbauer M, Bachl N, Tiran B, Tschan H. Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise. Eur J Appl Physiol 2010;110:695-701.
17. Lo YM, Rainer TH, Chan LY, Hjelm NM, Cocks RA. Plasma DNA as a prognostic marker in trauma patients. Clin Chem 2000;46:319-323.
18. Giacona MB, Ruben GC, Iczkowski KA, Roos TB, Porter DM, Sorenson GD. Cell-free DNA in human blood plasma: Length measurements of cell-free circulating DNA among patients with pancreatic cancer and healthy controls. Pancreas 1998;17:89-97.
19. Liggett T, Melnikov A, Yi QL, Replogle C, Brand R, Kaul K, Talamonti M, Abams RA, Levenson V. Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis. Cancer 2010;116:1674-1680.
20. Rainer TH, Wong LK, Lam W, Yuen E, Lam NY, Metreweli C, Lo YM. Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke. Clin Chem 2003;49:562-569.
21. Goebel G, Zitt M, Zitt M, Muller HM. Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasms. Dis Markers 2005;21:105-120.
22. Bird A. DNA methylationpatterns and epigenetic memory. Genes Dev 2002;16:6-21.
23. Sidransky D. Emerging molecular markers of cancer. Nature Rev Cancer 2002;2:210 -219.
24. Warren JD, Xiong W, Bunker AM, Vaughn CP, Furtado LV, Roberts WL, Fang JC, Samowitz WS, Heichman KA. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med. 2011 Dec 14;9:133.
25. Tóth K, Sipos F, Kalmár A, Patai AV, Wichmann B, Stoehr R, Golcher H, Schellerer V, Tulassay Z, Molnár B. Detection of Methylated SEPT9 in Plasma Is a Reliable Screening Method for Both Left- and Right-Sided Colon Cancers. PLoS One. 2012;7(9):e46000.
26. Liggett T, Melnikov A, Yi Q, Replogle C, Hu W, Rotmensch J, Kamat A, Sood AK, Levenson V. Distinctive DNA methylation patterns of cell-free plasma DNA in women with malignant ovarian tumors. Gynecol Oncol 2011;120:113-120