Long-term effects of perinatal androgenization on reproductive parameters of male rat offspring androgenization and male rat reproduction

Hormone and Metabolic Research

Volumn 45, Issue 8, 2013, Pages 586-592

  Guerra, M T ^a,b   Perobelli, J E ^a   Sanabria, M ^b   Anselmo Franci, J A ^c   De Grava Kempinas, W ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

fertility; perinatal androgenization; rat male offspring; sexual behavior; sperm counts

Indexed keywords

CORN OIL; ESTROGEN; FOLLITROPIN; LUTEINIZING HORMONE; PROGESTERONE; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ADULTHOOD; ANDROGEN THERAPY; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; EPIDIDYMIS; ESTROGEN BLOOD LEVEL; FOLLITROPIN BLOOD LEVEL; GESTATIONAL AGE; HISTOPATHOLOGY; LACTATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE FERTILITY; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROGENY; PROGESTERONE BLOOD LEVEL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; REPRODUCTION; SPERMATOGENESIS; TESTOSTERONE BLOOD LEVEL;

ANDROGENS; ANIMALS; FEMALE; FERTILITY; HUMANS; MALE; PERINATAL CARE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; REPRODUCTION; SEXUAL DEVELOPMENT; SPERM COUNT; SPERMATOZOA; TESTOSTERONE; TIME;

RATTUS; RATTUS NORVEGICUS; RODENTIA; ZEA MAYS;

EID: 84880513362     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1341434     Document Type: Article

References (49)

1. Jost A., Viger B., Prepin J., Perchellet J. P. Studies on sex differentiation in mammals. Recent Prog Horm Res: 1973; 29 1 4
2. Quadros P. S., Pfau J. L., Goldstein AY N., De Vries G. J., Wagner C. K. Sex differences in progresterone receptor expression: a potential mechanism for estradiol-mediated sexual differentiation. Endocrinology: 2002; 143 3727 3739 (Pubitemid 35244350)
3. Weisz J., Ward I. L. Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring. Endocrinology: 1980; 106 306 316 (Pubitemid 10212501)
4. Corbier P., Kerdelhue B., Picon R., Roffi J. Changes in testicular weight and serum gonadotropin and testosterone levels before, during, and after birth in the perinatal rat. Endocrinology: 1978; 103 1985 1991 (Pubitemid 9075933)
5. Bakker J. Sexual differentiation of the neuroendocrine mechanisms regulating mate recognition in mammals. J Neuroendocrinol: 2003; 15 615 621 (Pubitemid 36675316)
6. Zadina J. E., Dunlap J. L., Gerall A. A. Modifications induced by neonatal steroids in reproductive organs and behavior of male rats. J Comp Physiol Psychol: 1979; 93 314 322 (Pubitemid 9152383)
7. Piacsek B. E., Hostetter M. W. Neonatal androgenization in the male rat: evidence for central and peripheral defects. Biol Reprod: 1984; 30 344 351 (Pubitemid 14144459)
8. Gray L. E. Jr, Ostby J. S., Kelce W. R. Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol Appl Pharmacol: 1994; 129 46 52 (Pubitemid 24352621)
9. Radl V., Pritsch K., Munch J. C., Schloter M. Structural and functional diversity of microbial communities from a lake sediment contaminated with trenbolone, an endocrine-disrupting chemical. Environ Pollut: 2005; 137 345 353 (Pubitemid 40812412)
10. Swanson H. E., Van der Werff ten Bosch J. J. Sex differences in growth of rats and their modification by a single injection of testosterone propionate shortly after birth. J Endocrinol: 1963; 26 197 207
11. Moguilevsky J. A., Sacchi P., Rubinstein L. Effect of neonatal androgenization on luteinizing hormone, follicle stimulating hormone, prolactin and testosterone levels in male rats. J Endocrinol: 1977; 74 143 144 (Pubitemid 8139422)
12. Morrison R. L., Johnson D. C. The effect of androgenization in male rats castrated at birth. J Endocrinol: 1966; 34 117 123
13. Wolf C. J., LeBlanc G. A., Ostby J. S., Gray L. E. Jr. Characterization of the period of sensitivity of fetal male sexual development to vinclozolin. Toxicol Sci: 2000; 55 152 161 (Pubitemid 30252446)
14. Jones P. A., Takai D. The role of DNA methylation in mammalian epigenetics. Science: 2001; 293 1068 1070 (Pubitemid 32758075)
15. Wolf C. Jr, Lambright C., Mann P., Price M., Cooper R. L., Ostby J., Gray L. E. Jr. Administration of potentially antiandrogenic pesticide (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethanesulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health: 1999; 15 94 118 (Pubitemid 30484120)
16. Lumia A. R., Thorner K. M., McGinnis M. Y. Effects of Chronically high doses of the anabolic androgenic steroid, testosterone, on intermale aggression and sexual behavior in male rats. Physiol Behav: 1994; 55 331 335 (Pubitemid 24065243)
17. Wolf C. J., Hotchkiss A., Ostby J. S., LeBlanc G. A., Gray L. E. Jr. Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study. Toxicol Sci: 2002; 65 71 86 (Pubitemid 34092692)
18. Henley C. L., Nunez A. A., Clemens L. G. Exogenous androgen during development alters adult partner preference and mating behavior in gonadally intact rats. Horm Behav: 2010; 57 488 495
19. Nassr A. C., Arena A. C., Toledo F. C., Bissacot D. Z., Fernandez C. D., Spinardi-Barbisan A. L., Pires P. W., Kempinas W. G. Effects of gestational and lactational fenvalerate exposure on imune and reproductive systems of male rats. J Toxicol Environ Health A: 2010; 73 952 964
20. Foley G. L. Overview of male reproductive pathology. Mechanisms of male reproductive organ toxicity. Toxicol Pathol: 2001; 29 49 63
21. Perobelli J. E., Martinez M. F., Franchi CA S., Fernandez CD B., Camargo JL V., Kempinas W. G. Decreased sperm motility in rats orally exposed to single or mixed pesticides. J Toxicol Environ Health A: 2010; 73 991 1002
22. Seed J., Chapi R. E., Clegg E. D., Dostal L. A., Foote R. E., Hurtt M. E., Klinefelter G. R., Makris S. L., Perreault S. D., Schrader S., Seyler D., Sprando R., Treinen K. A., Veeramachaneni D. N., Wise L. D. Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. Reprod Toxicol: 1996; 10 237 244 (Pubitemid 126657490)
23. Filler R. Methods for evaluation of rats epididymal sperm morphology. In: Chapin R. E., Heindel J. H. (eds.). Male reproductive toxicology. California Academic Press: 1993; 334 343
24. Fernandes GS A., Arena A. C., Fernandez CD B., Mzercadante A., Barbisan L. F., Kempinas W. G. Reproductive effects in male rats exposed to diuron. Reprod Toxicol: 2007; 23 106 112 (Pubitemid 46027541)
25. Ågmo A. Male rat sexual behavior. Brain Res Protoc: 1997; 1 203 209 (Pubitemid 28281344)
26. Clegg E. D., Perreault S. D., Klinefelter G. R. Assessment of male reproductive toxicology. In: Hayes A. W. (ed.). Principles and methods of toxicology. Philadelphia Taylor & Francis: 2001; 1263 1299
27. Perobelli J. E., Alves T. R., Toledo F. C., Fernandez CD B., Anselmo-Franci J. A., Klinefelter G. R., Kempinas W. G. Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty. Reprod Toxicol: 2012; 33 308 315
28. Damasceno D. C., Kempinas W. G., Volpato G. T., Consonni M., Rudge MV C., Paumgartten FJ R. Modelos experimentais - Laparotomia. In: Anomalias congênitas. Belo Horizonte Coopmed: 2008; 13 21
29. MacLusky N. J., Naftolin F. Sexual differentiation of the central nervous system. Science: 1981; 211 1294 1303 (Pubitemid 11097283)
30. Hoepfner B. A., Ward I. L. Prenatal and neonatal androgen exposure interact to affect sexual differentiation in female rats. Behav Neurosci: 1988; 102 61 65
31. Sakuma Y. Gonadal steroid action and brain sex differentiation in the rat. J Neuroendocrinol: 2009; 21 410 414
32. Gray L. E. Chemical-induced alterations of sexual differentiation: a review of effects in humans and rodents. In: Colborn T., Clement C. (eds.). Advances in modern environmental toxicology Vol XXI. Chemically-induced alterations in sexual and functional development: the wildlife/human connection. Princeton Princeton Scientific: 1992; 203 230
33. Gerardin DC C., Pereira OC M. Reproductive changes in male rats treated with an aromatase inhibitor. Pharmacol Biochem Behav: 2002; 71 309 313 (Pubitemid 34102492)
34. Maqueo M., Kincl F. S. Testicular histomorphology of young rats treated with oestradiol 17β-benzoate. Acta Endocrinol: 1964; 46 25 30
35. Rajfer J., Coffey D. S. Effect of neonatal steroids on male se tissues. Invest Urol: 1979; 17 3 8 (Pubitemid 9239411)
36. Cruz C. D., Pereira OC M. Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats. J Physiol Sci: 2012; 62 123 131
37. Norris D. O. The Endocrinology if mammalian reproduction. In: Norris D. O. (eds.). Vertebrate Endocrinology. San Diego Academic Press: 1997; 357 406
38. Witt D. M., Young L. J., Crews D. Progesterone and sexual behavior in males. Psychoneuroendocrinology: 1994; 19 553 562
39. Kalra P. S., Kalra S. P. Circadian periodicities of serum androgens, progesterone, gonadotropins and luteinizing hormone-releasing hormone in male rats: The effects of hypothalamic deafferentation, castration and adrenalectomy. Endocrinology: 1977; 10 1821 1827 (Pubitemid 8243760)
40. Rifka S. M., Cutler G. B. Jr, Sauer M. A., Louriaux D. L. Rat adrenal androgen receptor: a possible mediator of androgen-induced decrease in rat adrenal weight. Endocrinology: 1978; 103 1103 1110 (Pubitemid 9047995)
41. McCormick C. M., Furey B. F., Child M., Sawyer M. J., Donohue S. M. Neonatal sex hormones have 'organizational' effects on the hypothalamic- pituitary-adrenal axis of male rats. Dev Brain Res: 1998; 105 295 307 (Pubitemid 28153437)
42. Serre V., Robaire B. Segment-specific morphological changes in aging brown Norway rat epididymis. Biol Reprod: 1998; 58 497 513 (Pubitemid 28099117)
43. Amann R. P. A Critical review of methods for evaluation of spermatogenesis from seminal characteristics. J Androl: 1981; 2 37 58
44. Andersson A. M., Jorgensen N., Main K. M., Toppari J., Rajpert-DeMeyts E., Leffers H., Juul A., Jensen T. K., Skakkebaek N. E. Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'. Int J Androl: 2008; 31 74 80 (Pubitemid 351341375)
45. Orgebin-Crist M. C. Studies on the function of the epididymis. Biol Reprod: 1969; 1 155 175
46. Kempinas W. G., Suarez J. D., Roberts N. L., Strader L., Ferrell J., Goldman J. M., Klinefelter G. R. Rat epididymal sperm quantity, quality, and transit after guanethidine-induced sympathectomy. Biol Reprod: 1998; 59 890 896 (Pubitemid 28463342)
47. Frick J., Chang C. C., Kincl F. A. Testosterone plasma levels in adult male rats injected neonatally with estradiol benzoate or testosterone propionate. Steroids: 1969; 13 21 27
48. Slob A. K., den Hamer R., Woutersen PJ A., van der Werff ten Bosch J. J. Prenatal testosterone propionate and postnatal ovarian activity in the rat. Acta Endocrinol: 1983; 103 420 427 (Pubitemid 13060447)
49. Amann R. P. Detection of alterations in testicular and epididymal function in laboratory animals. Environ Health Perspect: 1986; 70 149 158 (Pubitemid 17034346)