Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism

Transgenic Research

Volumn 22, Issue 4, 2013, Pages 757-766

  Deng, Jiao ^a,b   Li, Jiejie ^a,c   Li, Liaoliao ^a   Feng, Chenzhuo ^a   Xiong, Lize ^b   Zuo, Zhiyi ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Glutamate transporter; Heart rate; Mice; Parasympathetic tone

Indexed keywords

ATROPINE; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMIC ACID; SLC1A1 PROTEIN, MOUSE;

ANIMAL; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG EFFECT; GENETICS; HEART RATE; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY; SINUS NODE; SYNAPTIC TRANSMISSION; VAGUS NERVE;

ANIMALS; ATROPINE; CENTRAL NERVOUS SYSTEM; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMIC ACID; HEART RATE; HUMANS; MICE; MICE, KNOCKOUT; SINOATRIAL NODE; SYNAPTIC TRANSMISSION; VAGUS NERVE;

MUS;

EID: 84880510355     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-012-9680-5     Document Type: Article

References (29)

1. Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (1997) Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc Natl Acad Sci USA 94(8): 4155-4160.
2. Bailey CG, Ryan RM, Thoeng AD, Ng C, King K, Vanslambrouck JM, Auray-Blais C, Vandenberg RJ, Broer S, Rasko JE (2011) Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. J Clin Invest 121(1): 446-453.
3. Cifelli C, Rose RA, Zhang H, Voigtlaender-Bolz J, Bolz SS, Backx PH, Heximer SP (2008) RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res 103(5): 527-535.
4. Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65(1): 1-105.
5. Diamond JS (2001) Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells. J Neurosci 21(21): 8328-8338.
6. Gehrmann J, Hammer PE, Maguire CT, Wakimoto H, Triedman JK, Berul CI (2000) Phenotypic screening for heart rate variability in the mouse. Am J Physiol Heart Circ Physiol 279(2): H733-H740.
7. Griffioen KJ, Gorini C, Jameson H, Mendelowitz D (2007) Purinergic P2X receptors mediate excitatory transmission to cardiac vagal neurons in the nucleus ambiguus after hypoxia. Hypertension 50(1): 75-81.
8. Hinoi E, Takarada T, Ueshima T, Tsuchihashi Y, Yoneda Y (2004) Glutamate signaling in peripheral tissues. Eur J Biochem 271(1): 1-13.
9. Jameson HS, Pinol RA, Kamendi H, Mendelowitz D (2008) ATP facilitates glutamatergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain Res 1201: 88-92.
10. Janssen BJ, Smits JF (2002) Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification. Am J Physiol Regul Integr Comp Physiol 282(6): R1545-R1564.
11. Kanai Y, Hediger MA (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360(6403): 467-471.
12. Kondratskaya E, Shin MC, Akaike N (2010) Neuronal glutamate transporters regulate synaptic transmission in single synapses on CA1 hippocampal neurons. Brain Res Bull 81(1): 53-60.
13. Lee SN, Li L, Zuo Z (2010) Glutamate transporter type 3 knockout mice have a decreased isoflurane requirement to induce loss of righting reflex. Neuroscience 171(3): 788-793.
14. Lee S, Park S, Zuo Z (2012) Effects of isoflurane on learning and memory functions of wild-type and glutamate transporter type 3 knockout mice. J Pharm Pharmacol 64(2): 302-307.
15. Lehre KP, Levy LM, Ottersen OP, Storm-Mathisen J, Danbolt NC (1995) Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J Neurosci 15(3 Pt 1): 1835-1853.
16. Levenson J, Weeber E, Selcher JC, Kategaya LS, Sweatt JD, Eskin A (2002) Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake. Nat Neurosci 5(2): 155-161.
17. Li L, Zuo Z (2011) Glutamate transporter type 3 knockout reduces brain tolerance to focal brain ischemia in mice. J Cereb Blood Flow Metab 31(5): 1283-1292.
18. Liu J, Dobrzynski H, Yanni J, Boyett MR, Lei M (2007) Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovasc Res 73(4): 729-738.
19. Machado BH, Brody MJ (1988) Role of the nucleus ambiguus in the regulation of heart rate and arterial pressure. Hypertension 11(6 Pt 2): 602-607.
20. Meyer EC, Sommers DK, Schoeman HS, Avenant JC (1988) The effect of atropine on heart-rate: a comparison between two ethnic groups. Br J Clin Pharmacol 25(6): 776-777.
21. Palmer L, Edgar J, Lundgren G, Karlen B, Hermansson J (1981) Atropine in mouse brain and plasma quantified by mass fragmentography. Acta Pharmacol Toxicol (Copenh) 49(1): 72-76.
22. Peghini P, Janzen J, Stoffel W (1997) Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J 16(13): 3822-3832.
23. Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, Kuncl RW (1994) Localization of neuronal and glial glutamate transporters. Neuron 13(3): 713-725.
24. Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16(3): 675-686.
25. Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276(5319): 1699-1702.
26. Vela C, Diaz-Cabiale Z, Parrado C, Narvaez M, Covenas R, Narvaez JA (2010) Involvement of oxytocin in the nucleus tractus solitarii on central cardiovascular control: interactions with glutamate. J Physiol Pharmacol 61(1): 59-65.
27. Verheijck EE, van Kempen MJ, Veereschild M, Lurvink J, Jongsma HJ, Bouman LN (2001) Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution. Cardiovasc Res 52(1): 40-50.
28. Veruki ML, Morkve SH, Hartveit E (2006) Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signaling. Nat Neurosci 9(11): 1388-1396.
29. Wang J, Irnaten M, Neff RA, Venkatesan P, Evans C, Loewy AD, Mettenleiter TC, Mendelowitz D (2001) Synaptic and neurotransmitter activation of cardiac vagal neurons in the nucleus ambiguus. Ann N Y Acad Sci 940: 237-246.