Enzymatic Formulation Capable of Degrading Scrapie Prion under Mild Digestion Conditions

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Okoroma, Emeka A ^a   Purchase, Diane ^a   Garelick, Hemda ^a   Morris, Roger ^b   Neale, Michael H ^c,e   Windl, Otto ^c   Abiola, Oduola O ^d  

^a MIDDLESEX UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c VETERINARY LABORATORIES AGENCY   (United Kingdom)

^d UNIVERSITI BRUNEI DARUSSALAM   (Brunei Darussalam)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSURFACTANT; KERATINASE; PRION PROTEIN;

ANIMAL TISSUE; ARTICLE; BACILLUS LICHENIFORMIS; BRAIN HOMOGENATE; CELL CULTURE; CONTROLLED STUDY; DEGRADATION KINETICS; ENZYMATIC DEGRADATION; EX VIVO STUDY; IN VITRO STUDY; NONHUMAN; PSEUDOMONAS AERUGINOSA; SCRAPIE AGENT; SHEEP; TEMPERATURE; VIRUS INFECTIVITY;

ANIMALS; BACILLUS; CELL LINE; PEPTIDE HYDROLASES; PRIONS; PRPSC PROTEINS; PSEUDOMONAS AERUGINOSA; RABBITS; SHEEP;

EID: 84880499514     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068099     Document Type: Article

References (64)

1. World Health Organisation (1999) WHO infection control guidelines for transmissible spongiform encephalopathies. Report of a WHO Consultation. Geneva, Switzerland: WHO. Available: http//www.who.int/csr/resources/publications/bse/en/whocdscsraph2003.pdf. Accessed March 2009.
2. Collinge J, (2001) Prion diseases of humans and animals: their causes and molecular Basis. Annu Rev Neurosci 24: 519-550.
3. Taylor DM, Fraser H, McConnell I, Brown DA, Brown DL, et al. (1994) Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie. Arch Virol 139: 313-326.
4. Brown P, Gibbs CJ Jr, Amyx HL, Kingsbury DT, Rohwer RG, et al. (1982) Chemical disinfection of Creutzfeldt-Jakob disease virus. N Eng J Med 306: 1279-1282.
5. McDonnell G, Burke P, (2003) The challenges of prion decontamination. Clin Infect Dis 36: 1152-1154.
6. Edgeworth JA, Sicilia A, Linehan J, Brandner S, Jackson GS, et al. (2011) A standardized comparison of commercially available prion decontamination reagents using the Standard Steel-Binding Assay. J Gen Virol 92: 718-726.
7. Rutala WA, Weber DJ, (2010) Guideline for disinfection and sterilization of prion contaminated medical instruments. Infect Control Hosp Epidemiol 31: 107-117.
8. Brown SA, Merritt K, Woods TO, Busick DN, (2005) Effects on instruments of the World Health Organisation recommended protocols for decontamination after possible exposure to transmissible spongiform encephalopathy contaminated tissue. J Biomed Mater Res Part B Appl Biomater 72B: 186-190.
9. Taylor DM, (1999) Inactivation of prions by physical and chemical means. J Hosp Infect 43: S69-S76.
10. Defra (2005) BSE: Public health issues- Notification, disposal & compensation. Available:http://www.defra.gov.uk/animalh/bse/publichealth/notification.html. Accessed 13 Feb. 2009.
11. Jennette JP (2002) Medical Waste Management at Cornells College of Veterinary Medicine Available: http://www.cayugalake.org/newsletter/spring/2002/medicalwaste.html.Accessed Feb.2009.
12. Somerville RA, Fernie K, Smith A, Andrews R, Schmidt E, et al. (2009) Inactivation of TSE agent by a novel biorefinement system. Process Biochem. 44: 1060-1062.
13. Thacker HL, Kastner J (2004) Alkaline hydrolysis. Carcass disposal: A comprehensive review. Available: http://fss.k-state.edu/FeaturedContent/CarcassDisposal/PDF%20Files/CH%206%20-%20Alkaline%20Hydrolysis.pdf. Accessed Jan. 2009.
14. Kalambura S, Kricka T, Jukic Z, Voca N, Kalambura D, (2005) Alkaline hydrolysis of slaughterhouse waste. Krmiva 47: 97-100.
15. Yokoyama T, Shimada K, Tagawa Y, Ushiki YK, Iwamaru Y, et al. (2006) Western blot assessment of prion inactivation by alkali treatment in the process of horticultural fertilizer production from meat meal. Soil Sci Plant Nutr 52: 71-76.
16. Saunders SE, Burtett-Hunt SL, Bartz JC, (2008) Prions in the environment. Ocurrence, fate and mitigation. Prion 2: 162-169.
17. Brown P, Liberski PP, Wolff A, Gadjusek DC, (1990) Resistance of scrapie infectivity to steam autoclaving after formaldehyde fixation and limited survival after ashing at 360°C: Practical and theoretical implications. J Infect Dis 161: 467-472.
18. Brown P, Rau EH, Lemieux P, Johnson BK, Bacote AE, et al. (2004) Infectivity studies of both ash and air emissions from simulated incineration of scrapie-contaminated tissues. Environ Sci Technol 38: 6155-6160.
19. Woodward JB (2004) Grand Junction TSE incinerator. Available: http://www.maddeer.org/saved/022404woodward.html. Accessed 20 January 2009.
20. Coll BA, Garcia RA, Marmer WN (2007) Diffusion of protease into meat and bone meal for solubility improvement and potential inactivation of the BSE prion. PLoS ONE Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000245. Accessed April 2011.
21. Shih JCH (2002) Method and composition for sterilizing surgical instruments. US Patent Aplication. US 2002/0192731.
22. Langeveld JPM, Wang JJ, Van De Wiel DFM, Shih GC, et al. (2003) Enzymatic degradation of prion protein in brain stem from infected cattle and sheep. J Infect Dis 188: 1782-1789.
23. Huang H, Spencer JL, Soutyrine A, Guan J, Rendulich J, et al. (2007) Evidence for degradation of abnormal prion protein in tissues from sheep with scrapie during composting. Can J Vet Res 71: 34-40.
24. Rapp D, Potier P, Jocteur-Monrozier L, Richaume A, (2006) Prion degradation in soil: possible role of microbial enzyme simulated by the decomposition of buried carcasses. Environ Sci Technol 40: 6324-6329.
25. Saunders SE, Jason C, Bartz JC, Vercauteren CC, Bartelt-Hunt SL, (2011) An enzymatic treatment of soil-bound prions effectively inhibits replication. Appl Environ Microbiol 77: 4313-4317.
26. Cho HJ, (1983) Inactivation of the scrapie agent by pronase. Can J Comp Med 47: 494-496.
27. Tsiroulnikov K, Rezai H, Bonch-Osolovskaya E, Nedkov P, Gousterova A, et al. (2004) Hydrolysis of the amyloid prion protein and non-pathogenic meat and bone meal by anaerobic thermophilic prokaryotes and Streptomyces subspecies. J Agri Food Chem 52: 6353-6360.
28. McLeod AH, Murdoch H, Dickinson J, Dennis MJ, Hall GA, et al. (2004) Proteolytic inactivation of the bovine spongiform encephalopathy agent. Biochem Biophysic Res Comm 317: 1165-1170.
29. Jackson GS, Mckintosh E, Flechsig E, Prodromidou K, Hirsch P, et al. (2005) An enzyme-detergent method for effective prion decontamination of surgical steel. J Gen Virol 86: 869-878.
30. Lawson VA, Stewart JD, Masters CL, (2007) Enzymatic -detergent treatment protocol that reduces protease-resistant prion protein load and infectivity from surgical-steel monofilaments contaminated with a human derived prion strain. J Gen Virol 88: 2905-2914.
31. Croud VB, Collinge J, Jackson G (2008) Composition and methods for prion Decontamination. Unites States Patent Application Publication. US2008/0206843A1.
32. Dickinson J, Murdoch H, Dennis MJ, Hall GA, Bott R, et al. (2009) Decontamination of prion protein (BSE 301V) using genetically engineered protease. J Hosp Infect 72: 65-70.
33. Vilette D, Andreoletti O, Archer F, Madelaine MF, Vilotte JL, et al. (2001) Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein. Proc Natl Acad Sci USA 98: 4055-4059.
34. Hommel RK, (1990) Formation and physiological role of biosurfactants produced by hydrocarbon-utilizing microorganisms. Biodegradation 1: 107-119.
35. Muthusamy K, Gopalakrishnan S, Ravi TK, Sivachidambaram P, (2008) Biosurfactants: Properties, commercial production and application. Curr Sci 94: 736-747.
36. Hisatsuka K, Nakahara T, Sano N, Yamada K, (1971) Formation of rhamnolipid by Pseudomonas aeruginosa and its function in hydrocarbon fermentation. Agric Biol Chem 35: 686-692.
37. Soberon-Chavez G, Lepine F, Deziel E, (2005) Production of rhamnolipids by Pseudomonas aeruginosa. Appl Microbiol Biotechnol 68: 718-725.
38. Desai JD, Banat IM, (1997) Microbial production of surfactants and their commercial potential. Mol Biol Rev 61: 47-64.
39. Nitschke M, Coast SG, (2007) Biosurfactants in food industry. Trends Food Sci Technol 18: 252-259.
40. Wang Q, Fang X, Bai B, Liang X, Shuler PJ, (2007) Engineering bacteria for production of rhamnolipid as an agent for enhanced oil recovery. Biotechnol Bioeng 98: 842-853.
41. Deziel E, Paquette G, Villemur R, Lepine F, Bisaillon J, (1996) Biosurfactant production by a soil pseudomonas strain growing on polycyclic aromatic hydrocarbons. Appl Environ Microbial 62: 1908-1912.
42. Kosaric N, (2001) Biosurfactants and their application for soil remediation. Food Technol Biotechnol 39: 295-304.
43. Noordman WH, Jassen DB, (2002) Rhamnolipid stimulates uptake of hydrophobic compounds by Psuedomonas aeruginosa. Appl Environ Microbiol 68: 4502-4508.
44. Cao X-H, Liao Z-Y, Wang C-L, Yang W-Y, Lu M-F, (2009) Evaluation of a lipopeptide biosurfactant from Bacillus natto TK-1 as a potential source of anti-adhesive, antimicrobial and antitumor activities. Braz J Microbiol 40: 2373-379.
45. Rodrigues LR, Teixeira JA, van der mei HC, Oliveira R, (2006) Isolation and partial characterization of a biosurfactant produced by Streptococcus thermophilus A. Colloids Surf. B. Biointerfaces 53: 105-112.
46. Brzozowski B, Bednarski W, Golek P, (2011) The adhesive capability of two Lactobacillus strains and physiochemical properties of their synthesised biosurfactants. Food Technol Biotechnol 49: 177-186.
47. Singh A, Van Hamme JD, Ward OP, (2007) Surfactants in microbiology and biotechnology. Part 2: Application aspects. Biotechnol Adv 25: 99-121.
48. Piening N, Nonnon R, DiBari M, Walter S, Windl O, et al. (2006) Conversion efficiency of bank cole prion preotein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo. J Biol Chem 281: 9373-9384.
49. Mitsuiki S, Takasugi M, Moriyama Y, Futagami T, Golo M, et al. (2010) Identification of alkaliphilic actinomycetes that produces a PrPSc degrading enzyme. Am Microbiol 60: 349-353.
50. Okoroma EA, Garelick H, Abiola OO, Purchase D, (2012) Identification and characterisation of a Bacillus licheniformis strain with profound keratinase activity for degradation of melanised feather. Int Biodeter Biodegra 74: 54-60.
51. Zhang G, Wu Y, Qian X, Meng Q, (2005) Biodegradation of crude oil by Pseudomonas aeruginosa in the presence of rhamnolipids. J Zhejiang Uni Science 6B 8: 725-730.
52. Neale MH, Mountjoy SJ, Edwards JC, Vilette D, Laude H, et al. (2010) Infection of cell Lines with experimental and natural ovine scrapie agents. J Virol 84: 2444-2452.
53. Somerville RA, Oberthur RC, Havekost U, MacDonald F, Taylor DM, et al. (2002) Characterization of thermodynamic diversity between transmissible spongiform encephalopathy agent strains and its theoretical implications. J Biol Chem 277: 11084-11089.
54. Bolton DC, McKinley MP, Prusiner SB, (1984) Molecular characterisation of the major scrapie prion protein. Biochemistry 23: 5898-5906.
55. Oesch B, Jensen M, Nilsson P, Fogh J, (1994) Properties of scrapie prion protein: quantitative analysis of protease resistance. Biochemistry 33: 5926-5931.
56. Sharma R & Gupta R, (2010) Substrate specificity characterisation of a thermostable keratinase from Pseudomonas aeruginosa KS-1. J Ind Microbiol Biotechnol 37: 785-792.
57. Tork S, Aly MM, Nawar L, (2010) Biochemical and molecular characterisation of a new local keratinase producing Pseudomonas sp. MS21. Asian J Biotechnol 2: 1-13.
58. Ramnani P, Kumar SS, Gupta R, (2005) Concomitant production and downstream processing of alkaline protease and biosurfactant from Bacillus licheniformis RG1: Bioformulation as detergent additive. Process Biochem 40: 3353-3359.
59. Berardi VA, Cardone F, Valanzo A, Lu M, Pocchiari M, (2006) Preparation of soluble infectious samples from scrapie-infected brain: a new tool to study the clearance of transmissible spongiform encephalopathy agents during plasma fractionation. Transfusion 46: 652-658.
60. Barron RM, Campbell SL, King D, Bellon A, Chapman KE, et al. (2007) High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of prpSc in vivo. J Biol Chem 282: 35878-35886.
61. Lasmezas CI, Deslys JP, Robain O, Jaegly A, Beringue V, et al. (1997) Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein. Science 275: 402-405.
62. Suzuki Y, Tsujimoto Y, Matsui H, Watanabe K, (2006) Decomposition of extremely hard-to-degrade animal proteins by thermophilic bacteria. J Biosci 102: 73-81.
63. Pilon JL, Nash PB, Arver T, Hoglund D, Vercauteren KC, (2009) Feasibility of infectious prion digestion using mild conditions and commercial subtilisin. J Virol Meth 161: 168-172.
64. Karanth NGK, Deo PG, Veenanadig NK, (2005) Microbial production of biosurfactants and their importance. Cur Sci 77 (1): 116-126.