Degradation of MUC7 and MUC5B in Human Saliva

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Takehara, Sachiko ^a   Yanagishita, Masaki ^a   Podyma Inoue, Katarzyna Anna ^a   Kawaguchi, Yoko ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN; MUCIN 5B; MUCIN 7; SALIVA PROTEIN; SIALIDASE;

ADULT; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DEGLYCOSYLATION; FEMALE; HUMAN; MALE; MOLECULAR SIZE; NORMAL HUMAN; PROTEIN DEGRADATION; PROTEIN METABOLISM; SALIVA;

BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOSYLATION; HUMANS; MUCIN-5B; MUCINS; NEURAMINIDASE; PROTEOLYSIS; SALIVA; SALIVARY PROTEINS AND PEPTIDES;

EID: 84880444858     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069059     Document Type: Article

References (21)

1. Oppenheim FG, Salih E, Siqueira WL, Zhang W, Helmerhorst EJ, (2007) Salivary proteome and its genetic polymorphisms. Ann N Y Acad Sci 1098: 22-50.
2. Zalewska A, Zwierz K, Zolkowski K, Gindzienski A, (2000) Structure and biosynthesis of human salivary mucins. Acta Biochim Pol 47: 1067-1079.
3. Silverman HS, Parry S, Sutton-Smith M, Burdick MD, McDermott K, et al. (2001) In vivo glycosylation of mucin tandem repeats. Glycobiology 11: 459-471.
4. Perez-Vilar J, Randell SH, Boucher RC, (2004) C-Mannosylation of MUC5AC and MUC5B Cys subdomains. Glycobiology 14: 325-337.
5. Helmerhorst EJ, Oppenheim FG, (2007) Saliva: a dynamic proteome. J Dent Res 86: 680-693.
6. Gururaja TL, Levine JH, Tran DT, Naganagowda GA, Ramalingam K, et al. (1999) Candidacidal activity prompted by N-terminus histatin-like domain of human salivary mucin (MUC7)1. Biochim Biophys Acta 1431: 107-119.
7. Lis M, Bobek LA, (2008) Proteomic and metabolic characterization of a Candida albicans mutant resistant to the antimicrobial peptide MUC7 12-mer. FEMS Immunol Med Microbiol 54: 80-91.
8. Thornton DJ, Rousseau K, McGuckin MA, (2008) Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 70: 459-486.
9. Sterer N, Rosenberg M, (2002) Effect of deglycosylation of salivary glycoproteins on oral malodour production. Int Dent J 52Suppl 3: 229-232.
10. Varki A, (2008) Sialic acids in human health and disease. Trends Mol Med 14: 351-360.
11. Ponnio M, Alho H, Nikkari ST, Olsson U, Rydberg U, et al. (1999) Serum sialic acid in a random sample of the general population. Clin Chem 45: 1842-1849.
12. Bradshaw DJ, Homer KA, Marsh PD, Beighton D, (1994) Metabolic cooperation in oral microbial communities during growth on mucin. Microbiology 140: 3407-3412.
13. Van der Hoeven JS, Camp PJ, (1991) Synergistic degradation of mucin by Streptococcus oralis and Streptococcus sanguis in mixed chemostat cultures. J Dent Res 70: 1041-1044.
14. Byers HL, Homer KA, Beighton D, (1996) Utilization of sialic acid by viridans streptococci. J Dent Res 75: 1564-1571.
15. Sterer N, Rosenberg M, (2006) Streptococcus salivarius promotes mucin putrefaction and malodor production by Porphyromonas gingivalis. Journal of Dental Research 85: 910-914.
16. Kirkbride HJ, Bolscher JG, Nazmi K, Vinall LE, Nash MW, et al. (2001) Genetic polymorphism of MUC7: allele frequencies and association with asthma. Eur J Hum Genet 9: 347-354.
17. Bucki R, Namiot DB, Namiot Z, Savage PB, Janmey PA, (2008) Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13. J Antimicrob Chemother 62: 329-335.
18. Byers HL, Tarelli E, Homer KA, Beighton D, (2000) Isolation and characterisation of sialidase from a strain of Streptococcus oralis. J Med Microbiol 49: 235-244.
19. Wickstrom C, Herzberg MC, Beighton D, Svensater G, (2009) Proteolytic degradation of human salivary MUC5B by dental biofilms. Microbiology 155: 2866-2872.
20. Lecomte P, Dawes C, (1987) The influence of salivary flow rate on diffusion of potassium chloride from artificial plaque at different sites in the mouth. J Dent Res 66: 1614-1618.
21. Laemmli UK, (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.