Incorporation of Bone Marrow Cells in Pancreatic Pseudoislets Improves Posttransplant Vascularization and Endocrine Function

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Wittig, Christine ^a   Laschke, Matthias W ^a   Scheuer, Claudia ^a   Menger, Michael D ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GREEN FLUORESCENT PROTEIN; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; ENDOCRINE FUNCTION; FLUORESCENCE MICROSCOPY; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CAPSULE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PSEUDOISLET; SKINFOLD; STREPTOZOCIN DIABETES; SYRIAN HAMSTER; VASCULARIZATION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; CELL CULTURE TECHNIQUES; CRICETINAE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS TRANSPLANTATION; MESOCRICETUS; MICROSCOPY, FLUORESCENCE; TRANSPLANTS;

EID: 84880442115     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069975     Document Type: Article

References (42)

1. Ryan EA, Shandro T, Green K, Paty BW, Senior PA, et al. (2004) Assessment of the severity of hypoglycemia and glycemic lability in type 1 diabetic subjects undergoing islet transplantation. Diabetes 53: 955-962.
2. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, et al. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343: 230-238.
3. Naftanel MA, Harlan DM. Pancreatic islet transplantation (2004) PLoS Med; 1: e58; quiz e75.
4. Korsgren O, Nilsson B, Berne C, Felldin M, Foss A, et al. (2005) Current status of clinical islet transplantation. Transplantation 79: 1289-1293.
5. Menger MD, Yamauchi J, Vollmar B, (2001) Revascularization and microcirculation of freely grafted islets of Langerhans. World J Surg 25: 509-515.
6. Cui YF, Ma M, Wang GY, Han DE, Vollmar B, et al. (2005) Prevention of core cell damage in isolated islets of Langerhans by low temperature preconditioning. World J Gastroenterol 11: 545-550.
7. Mattsson G, Jansson L, Carlsson PO, (2002) Decreased vascular density in mouse pancreatic islets after transplantation. Diabetes 51: 1362-1366.
8. Penko D, Mohanasundaram D, Sen S, Drogemuller C, Mee C, et al. (2011) Incorporation of endothelial progenitor cells into mosaic pseudoislets. Islets 3: 73-79.
9. Gotoh M, Maki T, Satomi S, Porter J, Bonner-Weir S, et al. (1987) Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation 43: 725-730.
10. Cavallari G, Zuellig RA, Lehmann R, Weber M, Moritz W, (2007) Rat pancreatic islet size standardization by the "hanging drop" technique. Transplant Proc 39: 2018-2020.
11. Ricordi C, Gray DW, Hering BJ, Kaufman DB, Warnock GL, et al. (1990) Islet isolation assessment in man and large animals. Acta Diabetol Lat 27: 185-195.
12. Menger MD, Laschke MW, Vollmar B, (2002) Viewing the microcirculation through the window: some twenty years experience with the hamster dorsal skinfold chamber. Eur Surg Res 34: 83-91.
13. Menger MD, Vajkoczy P, Leiderer R, Jäger S, Messmer K, (1992) Influence of experimental hyperglycemia on microvascular blood perfusion of pancreatic islet isografts. J Clin Invest 90: 1361-1369.
14. Lipowsky HH, Zweifach BW, (1978) Application of the "two-slit" photometric technique to the measurement of microvascular volumetric flow rates. Microvasc Res 15: 93-101.
15. Gurney AM, Howarth FC, (2009) Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteries. Cardiovasc Diabetol 8: 4.
16. Nyqvist D, Köhler M, Wahlstedt H, Berggren PO, (2005) Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts. Diabetes 54: 2287-2293.
17. Menger MD, Jaeger S, Walter P, Feifel G, Hammersen F, et al. (1989) Angiogenesis and hemodynamics of microvasculature of transplanted islets of Langerhans. Diabetes 38(Suppl 1): 199-201.
18. Brissova M, Powers AC, (2008) Revascularization of transplanted islets: can it be improved? Diabetes 57: 2269-2271.
19. Vajkoczy P, Olofsson AM, Lehr HA, Leiderer R, Hammersen F, et al. (1995) Histogenesis and ultrastructure of pancreatic islet graft microvasculature. Evidence for graft revascularization by endothelial cells of host origin. Am J Pathol 146: 1397-1405.
20. Brissova M, Fowler M, Wiebe P, Shostak A, Shiota M, et al. (2004) Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes 53: 1318-1325.
21. Lukinius A, Jansson L, Korsgren O, (1995) Ultrastructural evidence for blood microvessels devoid of an endothelial cell lining in transplanted pancreatic islets. Am J Pathol 146: 429-435.
22. Furuya H, Kimura T, Murakami M, Katayama K, Hirose K, et al. (2003) Revascularization and function of pancreatic islet isografts in diabetic rats following transplantation. Cell Transplant 12: 537-544.
23. Dor Y, Glaser B, (2013) β-cell dedifferentiation and type 2 diabetes. N Engl J Med 368: 572-573.
24. Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, et al. (2010) Single pancreatic beta cells co-express multiple islet hormone genes in mice. Diabetologia 53: 128-138.
25. Menger MD, Vajkoczy P, Beger C, Messmer K, (1994) Orientation of microvascular blood flow in pancreatic islet isografts. J Clin Invest 93: 2280-2285.
26. Beger C, Cirulli V, Vajkoczy P, Halban PA, Menger MD, (1998) Vascularization of purified pancreatic islet-like cell aggregates (pseudoislets) after syngenic transplantation. Diabetes 47: 559-565.
27. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, et al. (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85: 221-228.
28. Miller R, Cirulli V, Diaferia GR, Ninniri S, Hardiman G, et al. (2008) Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells. Diabetes 57: 2402-2412.
29. Ranjan AK, Joglekar MV, Hardikar AA, (2009) Endothelial cells in pancreatic islet development and function. Islets 1: 2-9.
30. Tuche F, Menger MD, Körbel C, Nickels RM, Bouskela E, et al. (2012) Progenitor cell homing in the postischemic myocardium: just an unmotivated pitstop in the microcirculation? Microcirculation 19: 739-48.
31. Haider HK, (2006) Bone marrow cells for cardiac regeneration and repair: current status and issues. Expert Rev Cardiovasc Ther 4: 557-568.
32. Johansson U, Rasmusson I, Niclou SP, Forslund N, Gustavsson L, et al. (2008) Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization. Diabetes 57: 2393-2401.
33. Balestrieri ML, Lu SJ, de Nigris F, Giovane A, Williams-Ignarro S, et al. (2010) Therapeutic angiogenesis in diabetic apolipoprotein E-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention. Atherosclerosis 209: 403-414.
34. Faust A, Rothe H, Schade U, Lampeter E, Kolb H, (1996) Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10. Transplantation 62: 648-652.
35. Dobson T, Fraga D, Saba C, Bryer-Ash M, Gaber AO, et al. (2000) Human pancreatic islets transfected to produce an inhibitor of TNF are protected against destruction by human leukocytes. Cell Transplant 9: 857-865.
36. Noguchi H, Nakai Y, Ueda M, Masui Y, Futaki S, et al. (2007) Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor. Diabetologia 50: 612-619.
37. Ianus A, Holz GG, Theise ND, Hussain MA, (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 111: 843-850.
38. Hess D, Li L, Martin M, Hill D, Strutt B, et al. (2003) Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 21: 763-770.
39. Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, et al. (2004) Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes 53: 91-98.
40. Bonner-Weir S, Weir GC, (2005) New sources of pancreatic beta-cells. Nat Biotechnol 23: 857-861.
41. Rackham CL, Chagastelles PC, Nardi NB, Hauge-Evans AC, Jones PM, et al. (2011) Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice. Diabetologia 54: 1127-1135.
42. Lu Y, Jin X, Chen Y, Li S, Yuan Y, et al. (2010) Mesenchymal stem cells protect islets from hypoxia/reoxygenation-induced injury. Cell Biochem Funct 28: 637-643.