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Volumn 6, Issue 4, 2013, Pages 269-275

Initiating oral fingolimod treatment in patients with multiple sclerosis

Author keywords

fingolimod; multiple sclerosis; patient selection; risk; safety

Indexed keywords

AMINOTRANSFERASE; ANTIHYPERTENSIVE AGENT; ATROPINE; BETA1A INTERFERON; BILIRUBIN; FINGOLIMOD; GLATIRAMER; ISOPRENALINE; NATALIZUMAB; PLACEBO; STEROID;

EID: 84880391860     PISSN: 17562856     EISSN: 17562864     Source Type: Journal    
DOI: 10.1177/1756285613491520     Document Type: Article
Times cited : (29)

References (28)
  • 1
    • 84872346757 scopus 로고    scopus 로고
    • Cystoid macular edema associated with fingolimod use for multiple sclerosis
    • Afshar A. Fernandes J. Patel R. Ksiazek S. Sheth V. Reder A. et al. (2013) Cystoid macular edema associated with fingolimod use for multiple sclerosis. JAMA Ophthalmol 131: 103–107.
    • (2013) JAMA Ophthalmol , vol.131 , pp. 103-107
    • Afshar, A.1    Fernandes, J.2    Patel, R.3    Ksiazek, S.4    Sheth, V.5    Reder, A.6
  • 3
    • 84880843972 scopus 로고    scopus 로고
    • Efficacy and safety of fingolimod versus placebo: primary outcomes from the phase 3 FREEDOMS II study in patients with relapsing-remitting multiple sclerosis
    • Presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Lyon, France [abstract P491].
    • Calabresi P. Goodin D. Jeffery D. Kappos L. Lublin F. Rammohan K. et al. (2012) Efficacy and safety of fingolimod versus placebo: primary outcomes from the phase 3 FREEDOMS II study in patients with relapsing-remitting multiple sclerosis. Presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 10–13 October 2012, Lyon, France. [abstract P491].
    • (2012)
    • Calabresi, P.1    Goodin, D.2    Jeffery, D.3    Kappos, L.4    Lublin, F.5    Rammohan, K.6
  • 4
    • 84871181597 scopus 로고    scopus 로고
    • Severe relapses under fingolimod treatment prescribed after natalizumab
    • Centonze D. Rossi S. Rinaldi F. Gallo P. (2012) Severe relapses under fingolimod treatment prescribed after natalizumab. Neurology 79: 2004–2005.
    • (2012) Neurology , vol.79 , pp. 2004-2005
    • Centonze, D.1    Rossi, S.2    Rinaldi, F.3    Gallo, P.4
  • 5
    • 84555197737 scopus 로고    scopus 로고
    • A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya)
    • Chun J. Brinkmann V. (2011) A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya). Discov Med 12: 213–228.
    • (2011) Discov Med , vol.12 , pp. 213-228
    • Chun, J.1    Brinkmann, V.2
  • 6
    • 77951073508 scopus 로고    scopus 로고
    • Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
    • Chun J. Hartung H. (2010) Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin Neuropharmacol 33: 91–101.
    • (2010) Clin Neuropharmacol , vol.33 , pp. 91-101
    • Chun, J.1    Hartung, H.2
  • 7
    • 76149140914 scopus 로고    scopus 로고
    • Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • Cohen J. Barkhof F. Comi G. Hartung H. Khatri B. Montalban X. et al. (2010) Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 362: 402–415.
    • (2010) N Engl J Med , vol.362 , pp. 402-415
    • Cohen, J.1    Barkhof, F.2    Comi, G.3    Hartung, H.4    Khatri, B.5    Montalban, X.6
  • 8
    • 84993824689 scopus 로고    scopus 로고
    • Fingolimod treatment initiation experience: cardiac and Holter electrocardiogram findings from three phase 3 studies
    • Presented at of the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Lyon, France [abstract P530].
    • Di Marco J. O'Connor P. Cohen J. Reder A. Zhang-Auberson L. Tang D. et al. (2012) Fingolimod treatment initiation experience: cardiac and Holter electrocardiogram findings from three phase 3 studies. Presented at of the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 10–13 October 2012, Lyon, France [abstract P530].
    • (2012)
    • Di Marco, J.1    O'Connor, P.2    Cohen, J.3    Reder, A.4    Zhang-Auberson, L.5    Tang, D.6
  • 9
    • 62949147825 scopus 로고    scopus 로고
    • European Medicines Agency
    • Available at (accessed 27 November 2012).
    • European Medicines Agency. (2012). Available at: http://www.ema.europa.eu/ema/ (accessed 27 November 2012).
    • (2012)
  • 10
    • 35348970884 scopus 로고    scopus 로고
    • Brain penetration of the oral immunomodulatory drug FTY 720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis
    • Foster C. Howard L. Schweitzer A. Persohn E. Hiestand P. Balatoni B. et al. (2007) Brain penetration of the oral immunomodulatory drug FTY 720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. J Pharmacol Exp Ther 323: 469–475.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 469-475
    • Foster, C.1    Howard, L.2    Schweitzer, A.3    Persohn, E.4    Hiestand, P.5    Balatoni, B.6
  • 11
    • 84993694044 scopus 로고    scopus 로고
    • Lymphocytes and fingolimod - temporal pattern and relationship with infections
    • Presented at the 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis Gothenburg, Sweden [abstract P442].
    • Francis G. Kappos L. O'Connor P. Collins W. Zhang-Auberson L. de Vera A. et al. (2010) Lymphocytes and fingolimod - temporal pattern and relationship with infections. Presented at the 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, 13–16 October 2010, Gothenburg, Sweden [abstract P442].
    • (2010)
    • Francis, G.1    Kappos, L.2    O'Connor, P.3    Collins, W.4    Zhang-Auberson, L.5    de Vera, A.6
  • 12
    • 84867916552 scopus 로고    scopus 로고
    • Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach
    • Gasperini C. Ruggieri S. (2012) Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach. Drug Des Dev Ther 6: 175–186.
    • (2012) Drug Des Dev Ther , vol.6 , pp. 175-186
    • Gasperini, C.1    Ruggieri, S.2
  • 13
    • 84993694035 scopus 로고    scopus 로고
    • Gilenya® (fingolimod)
    • East Hanover, NJ: Novartis Pharmaceuticals Corporation
    • Gilenya® (fingolimod). (2012). Full Prescribing Information. East Hanover, NJ: Novartis Pharmaceuticals Corporation.
    • (2012) Full Prescribing Information
  • 14
    • 84871187559 scopus 로고    scopus 로고
    • Multiple sclerosis rebound following herpes zoster infection and suspension of fingolimod
    • Gross C. Baumgartner A. Rauer S. Stich O. (2012) Multiple sclerosis rebound following herpes zoster infection and suspension of fingolimod. Neurology 79: 2006–2007.
    • (2012) Neurology , vol.79 , pp. 2006-2007
    • Gross, C.1    Baumgartner, A.2    Rauer, S.3    Stich, O.4
  • 15
    • 84880363143 scopus 로고    scopus 로고
    • Macular edema associated with fingolimod
    • April
    • Jain N. Bhatti T. (2012) Macular edema associated with fingolimod. EyeNet April: 43–45.
    • (2012) EyeNet , pp. 43-45
    • Jain, N.1    Bhatti, T.2
  • 16
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • Kappos L. Radue E. O'Connor P. Polman C. Hohlfeld R. Calabresi P. et al. (2010) A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 362: 387–401.
    • (2010) N Engl J Med , vol.362 , pp. 387-401
    • Kappos, L.1    Radue, E.2    O'Connor, P.3    Polman, C.4    Hohlfeld, R.5    Calabresi, P.6
  • 18
    • 51449101000 scopus 로고    scopus 로고
    • Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial
    • Mikol D. Barkhof F. Chang P. Coyle P. Jeffery D. Schwid S. et al. (2008) Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial. Lancet Neurol 7: 903–914.
    • (2008) Lancet Neurol , vol.7 , pp. 903-914
    • Mikol, D.1    Barkhof, F.2    Chang, P.3    Coyle, P.4    Jeffery, D.5    Schwid, S.6
  • 19
    • 84993694042 scopus 로고    scopus 로고
    • Novartis
    • Dorval, Quebec, Canada Novartis Pharmaceuticals Canada Inc
    • Novartis (2012) PrGILENYA*, Fingolimod (as fingolimod hydrochloride). Dorval, Quebec, Canada: Novartis Pharmaceuticals Canada Inc.
    • (2012) PrGILENYA*, Fingolimod (as fingolimod hydrochloride)
  • 20
    • 69949098534 scopus 로고    scopus 로고
    • 250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study
    • O'Connor P. Filippi M. Arnason B. Comi G. Cook S. Goodin D. et al. (2009) 250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study. Lancet Neurol 8: 889–897.
    • (2009) Lancet Neurol , vol.8 , pp. 889-897
    • O'Connor, P.1    Filippi, M.2    Arnason, B.3    Comi, G.4    Cook, S.5    Goodin, D.6
  • 21
    • 70350135509 scopus 로고    scopus 로고
    • One-year MRI scan predicts clinical response to interferon beta in multiple sclerosis
    • Prosperini L. Gallo V. Petsas N. Borriello G. Pozzilli C. (2009) One-year MRI scan predicts clinical response to interferon beta in multiple sclerosis. Eur J Neurol 16: 1202–1209.
    • (2009) Eur J Neurol , vol.16 , pp. 1202-1209
    • Prosperini, L.1    Gallo, V.2    Petsas, N.3    Borriello, G.4    Pozzilli, C.5
  • 22
    • 84871255428 scopus 로고    scopus 로고
    • Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod
    • Ratchford J. Costello K. Reich D. Calabresi P. (2012) Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod. Neurology 79: 2002–2004.
    • (2012) Neurology , vol.79 , pp. 2002-2004
    • Ratchford, J.1    Costello, K.2    Reich, D.3    Calabresi, P.4
  • 23
    • 67649354558 scopus 로고    scopus 로고
    • Measures in the first year of therapy predict the response to interferon beta in MS
    • Rio J. Castillo J. Rovira A. Tintore M. Sastre-Garriga J. Horga A. et al. (2009) Measures in the first year of therapy predict the response to interferon beta in MS. Mult Scler 15: 848–853.
    • (2009) Mult Scler , vol.15 , pp. 848-853
    • Rio, J.1    Castillo, J.2    Rovira, A.3    Tintore, M.4    Sastre-Garriga, J.5    Horga, A.6
  • 24
    • 46749147136 scopus 로고    scopus 로고
    • Relationship between MRI lesion activity and response to IFN-beta in relapsing-remitting multiple sclerosis patients
    • Rio J. Rovira A. Tintore M. Huerga E. Nos C. Tellez N. et al. (2008) Relationship between MRI lesion activity and response to IFN-beta in relapsing-remitting multiple sclerosis patients. Mult Scler 14: 479–484.
    • (2008) Mult Scler , vol.14 , pp. 479-484
    • Rio, J.1    Rovira, A.2    Tintore, M.3    Huerga, E.4    Nos, C.5    Tellez, N.6
  • 25
    • 84860920485 scopus 로고    scopus 로고
    • Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response
    • Rio J. Tintore M. Sastre-Garriga J. Nos C. Castillo J. Tur C. et al. (2012) Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response. Eur J Neurol 19: 899-904.
    • (2012) Eur J Neurol , vol.19 , pp. 899-904
    • Rio, J.1    Tintore, M.2    Sastre-Garriga, J.3    Nos, C.4    Castillo, J.5    Tur, C.6
  • 26
    • 11144353922 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate
    • Sanna M. Liao J. Jo E. Alfonso C. Ahn M. Peterson M. et al. (2004) Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem 279: 13839–13848.
    • (2004) J Biol Chem , vol.279 , pp. 13839-13848
    • Sanna, M.1    Liao, J.2    Jo, E.3    Alfonso, C.4    Ahn, M.5    Peterson, M.6
  • 27
    • 60849112559 scopus 로고    scopus 로고
    • Injection anxiety remains a long-term barrier to medication adherence in multiple sclerosis
    • Turner A. Williams R. Sloan A. Haselkorn J. (2009) Injection anxiety remains a long-term barrier to medication adherence in multiple sclerosis. Rehabil Psychol 54: 116–121.
    • (2009) Rehabil Psychol , vol.54 , pp. 116-121
    • Turner, A.1    Williams, R.2    Sloan, A.3    Haselkorn, J.4
  • 28
    • 84871224051 scopus 로고    scopus 로고
    • Tumefactive multiple sclerosis lesions under fingolimod treatment
    • Visser F. Wattjes M. Pouwels P. Linssen W. van Oosten B. (2012) Tumefactive multiple sclerosis lesions under fingolimod treatment. Neurology 79: 2000–2003.
    • (2012) Neurology , vol.79 , pp. 2000-2003
    • Visser, F.1    Wattjes, M.2    Pouwels, P.3    Linssen, W.4    van Oosten, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.