Efficacy and safety of oral tranexamic acid in women with heavy menstrual bleeding and fibroids

Women's Health

Volumn 9, Issue 4, 2013, Pages 397-403

  Eder, Scott ^a   Baker, Jeffrey ^b   Gersten, Janet ^c   Mabey, R Garn ^d   Adomako, Tammie L ^e  

^a Women's Health Research Center   (United States)

^b Rosemark WomenCare Specialists   (United States)

^c Ferring Pharmaceuticals Inc   (United States)

^d Private Practice   (United States)

^e Ferring Pharmaceuticals Inc USA   (United States)

Author keywords

Fibroid; Heavy menstrual bleeding; Menorrhagia; Tranexamic acid; Women's health

Indexed keywords

HEMATIN; PLACEBO; TRANEXAMIC ACID;

ADULT; ANEMIA; BACKACHE; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL SYMPTOM; HEAVY MENSTRUAL BLEEDING; HUMAN; MAJOR CLINICAL STUDY; MENSTRUATION DISORDER; MULTIPLE CYCLE TREATMENT; MUSCULOSKELETAL PAIN; MYALGIA; NAUSEA; PARANASAL SINUSITIS; PHASE 3 CLINICAL TRIAL; PREMENSTRUAL SYNDROME; RACE DIFFERENCE; RANDOMIZED CONTROLLED TRIAL; REVIEW; TRANSVAGINAL ECHOGRAPHY; TREATMENT RESPONSE; UTERUS MYOMA; VALIDATION PROCESS; VIRAL UPPER RESPIRATORY TRACT INFECTION;

ADMINISTRATION, ORAL; ADULT; ANTIFIBRINOLYTIC AGENTS; FEMALE; HUMANS; LEIOMYOMA; MENORRHAGIA; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRANEXAMIC ACID; TREATMENT OUTCOME; UTERINE NEOPLASMS; YOUNG ADULT;

EID: 84880358349     PISSN: 17455057     EISSN: 17455065     Source Type: Journal    
DOI: 10.2217/whe.13.28     Document Type: Review

References (13)

1. NICE. Heavy Menstrual Bleeding. Guidelines 44. National Collaborating Centre for Women's and Children's Health, London, UK (2007).
2. Matteson KA, Boardman LA, Munro MG, Clark MA. Abnormal uterine bleeding: A review of patient-based outcome measures. Fertil. Steril. 92(1), 205-216 (2009).
3. Oehler MK, Rees MC. Menorrhagia: An update. Acta Obstet. Gynecol. Scand. 82(5), 405-422 (2003). (Pubitemid 36629848)
4. Nagele F, O'Connor H, Davies A, Badawy A, Mohamed H, Magos A. 2500 outpatient diagnostic hysteroscopies. Obstet. Gynecol. 88(1), 87-92 (1996). (Pubitemid 26197283)
5. Dockeray CJ, Sheppard BL, Daly L, Bonnar J. The fibrinolytic enzyme system in normal menstruation and excessive uterine bleeding and the effect of tranexamic acid. Eur. J. Obstet. Gynecol. Reprod. Biol. 24(4), 309-318 (1987). (Pubitemid 17065272)
6. Gupta S, Jose J, Manyonda I. Clinical presentation of fibroids. Best Pract. Res. Clin. Obstet. Gynaecol. 22(4), 615-626 (2008). (Pubitemid 351804119)
7. Moore K, Morin I, Marenco T, Lavigne JR, Morelli G. Pharmacokinetic studies of 2 novel oral formulations of tranexamic acid therapy for heavy menstrual bleeding. Am. J. Ther. 19(3), 190-198 (2012).
8. Freeman EW, Lukes A, VanDrie R, Mabey RG, Gersten J, Adomako TL. A dose-response study of a novel, oral tranexamic acid formulation for heavy menstrual bleeding. Am. J. Obstet. Gynecol. 205(4), 319.e1-319.e7 (2011).
9. Lukes AS, Moore KA, Muse KN et al. Tranexamic acid treatment for heavy menstrual bleeding: A randomized controlled trial. Obstet. Gynecol. 116, 865-875 (2010).
10. Muse K, Lukes AS, Gersten J, Waldbaum A, Mabey RG, Trott E. Long-term evaluation of safety and health-related quality of life in women with heavy menstrual bleeding treated with oral tranexamic acid. Womens Health 7(6), 699-707 (2011).
11. Lukes AS, Freeman EW, Van Drie D, Baker J, Adomako TL. Safety of tranexamic acid in women with heavy menstrual bleeding: An open-label extension study. Womens Health 7(5), 591-598 (2011).
12. Lukes AS, Baker J, Eder S, Adomako TL. Daily menstrual blood loss and quality of life in women with heavy menstrual bleeding. Womens Health 8(5), 503-511 (2012).
13. Muse K, Mabey RG, Waldbaum A, Gersten JK, Adomako TL. Tranexamic acid increases hemoglobin and ferritin levels in women with heavy menstrual bleeding. J. Womens Health (Larchmt) 21(7), 756-761 (2012).