Tranexamic acid increases hemoglobin and ferritin levels in women with heavy menstrual bleeding

Journal of Women's Health

Volumn 21, Issue 7, 2012, Pages 756-761

  Muse, Ken ^a   Mabey, R Garn ^b   Waldbaum, Arthur ^c   Gersten, Janet K ^d   Adomako, Tammie L ^e  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b Private Practice   (United States)

^c Downtown Women's Health Care   (United States)

^d Ferring Pharmaceuticals Inc   (United States)

^e Ferring Pharmaceuticals Inc USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEMOGLOBIN; TRANEXAMIC ACID;

ADULT; ARTICLE; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FERRITIN BLOOD LEVEL; HEAVY MENSTRUAL BLEEDING; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; IRON DEFICIENCY ANEMIA; IRON THERAPY; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; MENSTRUAL IRREGULARITY; MULTICENTER STUDY; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; ANEMIA, IRON-DEFICIENCY; ANTIFIBRINOLYTIC AGENTS; FEMALE; FERRIC COMPOUNDS; FERRITINS; HEMOGLOBINS; HUMANS; MENORRHAGIA; MIDDLE AGED; TRANEXAMIC ACID;

EID: 84863686935     PISSN: 15409996     EISSN: 1931843X     Source Type: Journal    
DOI: 10.1089/jwh.2011.3163     Document Type: Article

References (23)

1. Hallberg L, Hogdahl AM, Nilsson L, et al. Menstrual blood loss-A population study. Variation at different ages and attempts to define normality. Acta Obstet Gynecol Scand 1966;45:320-351.
2. Wathen PI, Henderson MC, Witz CA. Abnormal uterine bleeding. Med Clin North Am 1995;79:329-344.
3. Cohen BJ, Gibor Y. Anemia and menstrual blood loss. Obstet Gynecol Surv 1980;35:597-618.
4. Liu Z, Doan QV, Blumenthal P, et al. A systematic review evaluating health-related quality of life, work impairment, and health-care costs and utilization in abnormal uterine bleeding. Value Health 2007;10:183-194.
5. Morrison J, Patel ST, Watson W, et al. Assessment of the prevalence and impact of anemia on women hospitalized for gynecologic conditions associated with heavy uterine bleeding. J Reprod Med 2008;53:323-330.
6. Wellington K, Wagstaff AJ. Tranexamic acid: A review of its use in the management of menorrhagia. Drugs 2003;63: 1417-1433.
7. Dunn CJ, Goa KL. Tranexamic acid: A review of its use in surgery and other indications. Drugs 1999;57:1005-1032.
8. Preston JT, Cameron IT,Adams EJ, et al. Comparative study of tranexamic acid and norethisterone in the treatment of ovulatory menorrhagia. Br J Obstet Gynaecol 1995;102:401-406.
9. Nilsson L, Rybo G. Treatment of menorrhagia with an antifibrinolytic agent, tranexamic acid (AMCA). Acta Obstet Gynecol Scand 1967;46:572-580.
10. Moore KA, Morin I, Marenco T, et al. Pharmacokinetic studies in women of 2 novel oral formulations of tranexamic acid therapy for heavy menstrual bleeding. Am J Ther 2011 [Epub ahead of print]
11. Tranexamic acid (Lysteda) for treatment of menorrhagia. Med Lett Drugs Ther 2010;52:54-55
12. Lukes AS, Moore KA, Muse KN, et al. Tranexamic acid treatment for heavy menstrual bleeding: A randomized controlled trial. Obstet Gynecol 2010;116:865-875.
13. Muse K, Lukes AS, Gersten J, et al. Long-term evaluation of safety and health-related quality of life in women with heavy menstrual bleeding treated with oral tranexamic acid. Womens Health (Lond Engl) 2011;7:699-707.
14. Apgar BS, Kaufman AH, George-Nwogu U, et al. Treatment of menorrhagia. Am Fam Physician 2007;75:1813-1819.
15. Coulter A, Peto V, Jenkinson C. Quality of life and patient satisfaction following treatment for menorrhagia. Fam Pract 1994;11:394-401.
16. Shapley M, Jordan K, Croft PR. Why women consult with increased vaginal bleeding: A case-control study. Br J Gen Pract 2002;52:108-113.
17. Milsom I, Andersson K, Andersch B, et al. A comparison of flurbiprofen, tranexamic acid, and a levonorgestrel-releasing intrauterine contraceptive device in the treatment of idiopathic menorrhagia. Am J Obstet Gynecol 1991;164:879-883.
18. Ylikorkala O, Viinikka L. Comparison between antifibrinolytic and antiprostaglandin treatment in the reduction of increased menstrual blood loss in women with intrauterine contraceptive devices. Br J Obstet Gynaecol 1983;90:78-83.
19. Winkler UH. The effect of tranexamic acid on the quality of life of women with heavy menstrual bleeding. Eur J Obstet Gynecol Reprod Biol 2001;99:238-243.
20. Guyatt GH, Patterson C, Ali M, et al. Diagnosis of irondeficiency anemia in the elderly. Am J Med 1990;88:205-209.
21. Lotz J, Hafner G, Prellwitz W. Reference values for a homogeneous ferritin assay and traceability to the 3rd International Recombinant Standard for Ferritin (NIBSC code 94/ 572). Clin Chem Lab Med 1999;37:821-825.
22. Gleeson NC, Buggy F, Sheppard BL, et al. The effect of tranexamic acid on measured menstrual loss and endometrial fibrinolytic enzymes in dysfunctional uterine bleeding. Acta Obstet Gynecol Scand 1994;73:274-277.
23. de Souza SS, Camargos AF, Ferreira MC, et al. Hemoglobin levels predict quality of life in women with heavy menstrual bleeding. Arch Gynecol Obstet 2010;281:895-900.