Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in merkel cell carcinoma

Journal of Investigative Dermatology

Volumn 133, Issue 8, 2013, Pages 2065-2073

  Afanasiev, Olga K ^a   Nagase, Kotaro ^b   Simonson, William ^a   Vandeven, Natalie ^a   Blom, Astrid ^a   Koelle, David M ^a,c,d   Clark, Rachael ^e   Nghiem, Paul ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SAGA UNIVERSITY   (Japan)

^c Fred Hutchinson Cancer Research Center   (United States)

^d BENAROYA RESEARCH INSTITUTE   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; BIOLOGICAL MARKER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; NITRIC OXIDE; REACTIVE NITROGEN SPECIES;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CANCER SURVIVAL; CAUSE SPECIFIC SURVIVAL; CD8+ T LYMPHOCYTE; CELL DISRUPTION; CELL MIGRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE EVASION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MERKEL CELL TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN PENETRATION;

EID: 84880332726     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.36     Document Type: Article

References (34)

1. Bronte V, Kasic T, Gri G et al. (2005) Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med 201:1257-68 (Pubitemid 40629069)
2. Chong BF, Murphy J-E, Kupper TS et al. (2004) E-selectin, thymus-and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system. J Immunol 172:1575-81 (Pubitemid 38116803)
3. Clark RA, Huang SJ, Murphy GF et al. (2008) Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med 205:2221-34
4. Cuzick J (1985) A Wilcoxon-type test for trend. Stat Med 4:87-90 (Pubitemid 15142530)
5. Czéh M, Loddenkemper C, Shalapour S et al. (2010) The immune response to sporadic colorectal cancer in a novel mouse model. Oncogene 29:6591-602
6. De Santo C, Serafini P, Marigo I et al. (2005) Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination. Proc Natl Acad Sci USA 102:4185-90 (Pubitemid 40388577)
7. Eiserich JP, Butler J, van der Vliet A et al. (1995) Nitric oxide rapidly scavenges tyrosine and tryptophan radicals. Biochem J 310(Pt 3):745-9
8. Engels EA, Frisch M, Goedert JJ et al. (2002) Merkel cell carcinoma and HIV infection. Lancet 359:497-8 (Pubitemid 34164301)
9. Feng H, Shuda M, Chang Y et al. (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319:1096-100 (Pubitemid 351300792)
10. Fleiss J (1981) Statistical Methods for Rates and Proportions. 2nd edn John Wiley: New York
11. Gehad AE, Lichtman MK, Schmults CD et al. (2012) Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas. J Invest Dermatol 132:2642-51
12. Heath M, Jaimes N, Lemos B et al. (2008) Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol 58:375-81 (Pubitemid 351226308)
13. Iyer JG, Afanasiev OK, McClurkan C et al. (2011) Merkel cell polyomavirusspecific CD8\+ and CD4\+ T-cell responses identified in merkel cell carcinomas and blood. Clin Cancer Res 17:6671-80
14. Kasic T, Colombo P, Soldani C et al. (2011) Modulation of human T-cell functions by reactive nitrogen species. Eur J Immunol 41:1843-9
15. Kulidjian AA, Issekutz AC, Issekutz TB (2002) Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines. Int Immunol 14:751-60 (Pubitemid 34814635)
16. Kupper TS, Fuhlbrigge RC (2004) Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 4:211-22 (Pubitemid 38339087)
17. Lemos BD, Storer BE, Iyer JG et al. (2010) Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 63:751-61
18. Liou H-C (2002) Regulation of the immune system by NF-kappaB and IkappaB. J Biochem Mol Biol 35:537-46 (Pubitemid 43142909)
19. Luo J, Lin J, Paranya G et al. (1998) Angiostatin upregulates E-selectin in proliferating endothelial cells. Biochem Biophys Res Commun 245:906-11 (Pubitemid 28414016)
20. Mann AP, Tanaka T (2011) E-selectin: its role in cancer and potential as a biomarker. Transl Med 01:1
21. Molon B, Ugel S, Del Pozzo F et al. (2011) Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med 208:1949-62
22. Nagaraj S, Gupta K, Pisarev V et al. (2007) Altered recognition of antigen is a mechanism of CD8\+ T cell tolerance in cancer. Nat Med 13:828-35 (Pubitemid 47038194)
23. Nagaraj S, Schrum AG, Cho H-I et al. (2010) Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. J Immunol 184:3106-16
24. Nathan C, Ding A (2010) SnapShot: reactive oxygen intermediates (ROI). Cell 140:951
25. Paulson KG, Iyer JG, Blom A et al. (2012) Systemic immune suppression as a stage-independent predictor of diminished Merkel cell carcinoma-specific survival. J Invest Dermatol (doi:10.1038/jid.2012.388)
26. Paulson KG, Iyer JG, Tegeder AR et al. (2011) Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8\+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol 29:1539-46
27. Penn I (1999) Posttransplant malignancies. Transplant Proc 31:1260-2 (Pubitemid 29127895)
28. Radi R (2004) Nitric oxide, oxidants, and protein tyrosine nitration. Proc Natl Acad Sci USA 101:4003-8 (Pubitemid 38405874)
29. Sawa T, Akaike T, Maeda H (2000) Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase. J Biol Chem 275:32467-74
30. Schaerli P, Ebert L, Willimann K et al. (2004) A skin-selective homing mechanism for human immune surveillance T cells. J Exp Med 199:1265-75 (Pubitemid 38620263)
31. Sihto H, Bohling T, Kavola H et al. (2012) Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study. Clin Cancer Res 18:2872-81
32. Szabó C, Ischiropoulos H, Radi R (2007) Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 6:662-80 (Pubitemid 47207751)
33. Weishaupt C, Munoz KN, Buzney E et al. (2007) T-cell distribution and adhesion receptor expression in metastatic melanoma. Clin Cancer Res 13:2549-56 (Pubitemid 46788020)
34. Wyble CW, Hynes KL, Kuchibhotla J et al. (1997) TNF-alpha and IL-1 upregulate membrane-bound and soluble E-selectin through a common pathway. J Surg Res 73:107-12 (Pubitemid 28067293)