P40 (ΔNp63) and keratin 34βE12 provide greater diagnostic accuracy than p63 in the evaluation of small cell lung carcinoma in small biopsy samples

Human Pathology

Volumn 44, Issue 8, 2013, Pages 1479-1486

  Butnor, Kelly J ^a   Burchette, James L ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Np63; Bronchoscopic biopsy; Immunohistochemistry; Keratin 34 E12; p40; p63; Small cell lung carcinoma

Indexed keywords

KERATIN 34; PROTEIN P40; PROTEIN P63; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; BRONCHOSCOPY; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG BIOPSY; LUNG SMALL CELL CANCER;

ΔNP63; BRONCHOSCOPIC BIOPSY; IMMUNOHISTOCHEMISTRY; KERATIN 34ΒE12; P40; P63; SMALL CELL LUNG CARCINOMA;

BIOPSY; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LUNG NEOPLASMS; SMALL CELL LUNG CARCINOMA; TUMOR MARKERS, BIOLOGICAL;

EID: 84880330627     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.01.011     Document Type: Article

References (34)

1. J. Terry, S. Leung, J. Laskin, K.O. Leslie, A.M. Gown, and D.N. Ionescu Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples Am J Surg Pathol 34 2010 1805 1811
2. S. Mukhopadhyay, and A.L. Katzenstein Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6 Am J Surg Pathol 35 2011 15 25
3. N. Rekhtman, D.C. Ang, C.S. Sima, W.D. Travis, and A.L. Moreira Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens Mod Pathol 24 2011 1348 1359
4. H. Battifora, and E.G. Silva The use of antikeratin antibodies in the immunohistochemical distinction between neuroendocrine (Merkel cell) carcinoma of the skin, lymphoma, and oat cell carcinoma Cancer 58 1986 1040 1046
5. W.D. Travis Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas Mod Pathol 25 Suppl 1 2012 S18 S30
6. M.H. Lyda, and L.M. Weiss Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas Hum Pathol 31 2000 980 987
7. L. Viberti, M. Bongiovanni, S. Croce, and G. Bussolati 34BetaE12 cytokeratin immunodetection in the differential diagnosis of small cell tumors of lung Int J Surg Pathol 8 2000 317 322
8. N. Sturm, G. Rossi, and S. Lantuejoul 34BetaE12 expression along the whole spectrum of neuroendocrine proliferations of the lung, from neuroendocrine cell hyperplasia to small cell carcinoma Histopathology 42 2003 156 166
9. B.Y. Wang, J. Gil, D. Kaufman, L. Gan, D.S. Kohtz, and D.E. Burstein p63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors Hum Pathol 33 2002 921 926
10. G. Pelosi, F. Pasini, and C. Olsen Stenholm p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas? J Pathol 198 2002 100 109
11. M. Wu, B. Wang, and J. Gil p63 and TTF-1 immunostaining. A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of lung Am J Clin Pathol 119 2003 696 702
12. N.H. Au, A.M. Gown, and M. Cheang p63 expression in lung carcinoma: a tissue microarray study of 408 cases Appl Immunohistochem Mol Morphol 12 2004 240 247
13. H. Zhang, J. Liu, P.T. Cagle, T.C. Allen, A.C. Laga, and D.S. Zander Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: an immunohistochemical approach Mod Pathol 18 2005 111 118
14. K. Hiroshima, A. Iyoda, and T. Shida Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis Mod Pathol 19 2006 1358 1368
15. N. Kalhor, D.S. Zander, and J. Liu TTF-1 and p63 for distinguishing pulmonary small-cell carcinoma from poorly differentiated squamous cell carcinoma in previously pap-stained cytologic material Mod Pathol 19 2006 1117 1123
16. A. Kargi, D. Gurel, and B. Tuna The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas Appl Immunohistochem Mol Morphol 15 2007 415 420
17. Z. Maleki Diagnostic issues with cytopathologic interpretation of lung neoplasms displaying high-grade basaloid or neuroendocrine morphology Diagn Cytopathol 39 2011 159 167
18. J.A. Bishop, J. Teruya-Feldstein, W.H. Westra, G. Pelosi, W.D. Travis, and N. Rekhtman p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma Mod Pathol 25 2012 405 415
19. G. Pelosi, A. Fabbri, and F. Bianchi ΔNp63 (p40) and thyroid transcription factor-1 immunoreactivity on small biopsies or cellblocks for typing non-small cell lung cancer: a novel two-hit, sparing-material approach J Thorac Oncol 7 2012 281 290
20. D. Nonaka A study of ΔNp63 expression in lung non-small cell carcinomas Am J Surg Pathol 36 2012 895 899
21. G. Pelosi, G. Rossi, and A. Cavazza Immunoreactivity for deltanp63-p40, a basal-type marker, as a holistic, single-shot diagnostic adjunct approach to morphology for lung cancer subtyping Mod Pathol 25 2012 486a
22. W.D. Travis, E. Brambilla, H.K. Muller-Hermelink, and C.C. Harris World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymas and Heart 2004 IARC Press Lyon
23. A. Matoso, K. Singh, and R. Jacob Comparison of thyroid transcription factor-1 expression by 2 monoclonal antibodies in pulmonary and nonpulmonary primary tumors Appl Immunohistochem Mol Morphol 18 2010 142 149
24. E. Comperat, F. Zhang, and C. Perrotin Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin Mod Pathol 18 2005 1371 1376
25. S. Mukhopadhyay, and A.L. Katzenstein Comparison of monoclonal napsin A, polyclonal napsin S, and TTF-1 for determining lung origin in metastatic adenocarcinomas Am J Clin Pathol 138 2012 703 711
26. N.S. Goldstein, M. Ferkowicz, E. Odish, A. Mani, and F. Hastah Minimum formalin fixation time for consistent estrogen receptor immunohistochemical staining of invasive breast carcinoma Am J Clin Pathol 120 2003 86 92
27. N. Sturm, G. Rossi, and S. Lantuejoul Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell lung proliferations with special interest in carcinoids Hum Pathol 33 2002 175 182
28. D.G. Guinee Jr., N.F. Fishback, M.N. Koss, S.L. Abbondanzo, and W.D. Travis The spectrum of immunohistochemical staining of small-cell lung carcinoma in specimens from transbronchial and open-lung biopsies Am J Clin Pathol 102 1994 406 414
29. K. Kontogianni, A.G. Nicholson, D. Butcher, and M.N. Sheppard CD56: a useful tool for the diagnosis of small cell lung carcinomas on biopsies with extensive crush artefact J Clin Pathol 58 2005 978 980
30. D.N. Ionescu, D. Treaba, and C.B. Gilks Nonsmall cell lung carcinoma with neuroendocrine differentiation - an entity of no clinical or prognostic significance Am J Surg Pathol 31 2007 26 32
31. F. Gonzalez-Aragoneses, N. Moreno-Mata, and M. Cebollero-Presmanes Prognostic significance of synaptophysin in stage I of squamous carcinoma and adenocarcinoma of the lung Cancer 110 2007 1776 1781
32. S.W. Shy, W.H. Lee, M.C. Chou, Y.S. Lai, and Y.C. Tu Small cell lung carcinoma: clinicopathological, immunohistochemical, and ultrastructural study J Surg Oncol 45 1990 146 161
33. D.H. Johnson, L. Fehrenbacher, and W.F. Novotny Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer J Clin Oncol 22 2004 2184 2191
34. D.R. Spigel, P.M. Townley, and D.M. Waterhouse Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: results from the SALUTE trial J Clin Oncol 29 2011 2215 2222