Selectively bred rat model system for low and high response to exercise training

Physiological Genomics

Volumn 45, Issue 14, 2013, Pages 606-614

  Koch, Lauren Gerard ^a   Pollott, Geoffrey E ^b   Britton, Steven L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Aerobic capacity; Exercise training response; Gene environment interaction; Inbred strains

Indexed keywords

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREED DIFFERENCE; ENDURANCE TRAINING; EXERCISE TOLERANCE; EXPERIMENTAL MODEL; FEMALE; GENETIC SELECTION; GENOTYPE ENVIRONMENT INTERACTION; HERITABILITY; HIGH RESPONSE TRAINER; INBRED STRAIN; LOW RESPONSE TRAINER; MALE; NONHUMAN; PEDIGREE; PRIORITY JOURNAL; RAT; RAT STRAIN; RUNNING; TREADMILL EXERCISE;

EID: 84880319434     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00021.2013     Document Type: Article

References (49)

1. Albert FW, Carlborg O, Plyusnina I, Besnier F, Hedwig D, Lautenschlager S, Lorenz D, McIntosh J, Neumann C, Richter H, Zeising C, Kozhemyakina R, Shchepina O, Kratzsch J, Trut L, Teupser D, Thiery J, Schoneberg T, Andersson L, Paabo S. Genetic architecture of tameness in a rat model of animal domestication. Genetics 182: 541-554, 2009.
2. Blair SN, Kampert JB, Kohl HW 3rd, Barlow CE, Macera CA, Paffenbarger RS, Jr, Gibbons LW. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 276: 205-210, 1996.
3. Blair SN, Kohl HW 3rd, Barlow CE, Paffenbarger RS, Jr, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality A prospective study of healthy and unhealthy men. JAMA 273: 1093-1098, 1995.
4. Blair SN, Kohl HW 3rd, Paffenbarger RS Jr, Clark DG, Cooper KH, and Gibbons LW. Physical fitness and all-cause mortality A prospective study of healthy men and women. JAMA 262: 2395-2401, 1989.
5. 2 max response to exercise training: results from the Heritage family study. J Appl Physiol 87: 1003-1008, 1999.
6. Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Häkkinen K, Jenkins NT, Karavirta L, Kraus WE, Leon AS, Rao DC, Sarzynski MA, Skinner JS, Slentz CA, Rankinen T. Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS One 7: e37887, 2012.
7. Bouchard C, Lesage R, Lortie G, Simoneau JA, Hamel P, Boulay MR, Perusse L, Theriault G, LeBlanc C. Aerobic performance in brothers, dizygotic and monozygotic twins. Med Sci Sports Exerc 18: 639-646, 1986.
8. Bouchard C, Rankinen T, Chagnon YC, Rice T, Perusse L, Gagnon J, Borecki I, An P, Leon AS, Skinner JS, Wilmore JH, Province M, Rao DC. Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE family study. J Appl Physiol 88: 551-559, 2000.
9. Britton SL, Koch LG. Selection experiments in rodents to define the complexity and diversity of endurance capacity. In: Genetic and Molecular Aspects of Sport Performance, edited by Bouchard C, Hoffman EP. Chichester, UK: Wiley-Blackwell, 2011, p. 133-147.
10. Carlborg O, Jacobsson L, Ahgren P, Siegel P, Andersson L. Epistasis and the release of genetic variation during long-term selection. Nat Genet 38: 418-420, 2006.
11. Church TS, Cheng YJ, Earnest CP, Barlow CE, Gibbons LW, Priest EL, Blair SN. Exercise capacity and body composition as predictors of mortality among men with diabetes. Diabetes Care 27: 83-88, 2004.
12. Dickerson GE. Genetic slippage in response to selection for multiple objectives. Cold Spring Harb Sym 20: 213-224, 1955.
13. Ek W, Stromstedt L, Wahlberg P, Siegel P, Andersson L, Carlborg O. Genetic analysis of metabolic traits in an intercross between body weightselected chicken lines. Physiol Genomics 42: 20-22, 2010.
14. Falconer DS. Genetic aspects of breeding methods. In: The UFAW Handbook on the Care and Management of Laboratory Animals. Edinburgh, UK: Churchill Livingstone, 1976, p. 7-26.
15. Falconer DS, Mackay TFC. Introduction to Quantitative Genetics. Essex, UK: Addison Wesley Longman, 1996.
16. Fisher RA. The Genetical Theory of Natural Selection. New York: Dover, 1958.
17. Gilmour AR, Gogel BJ, Cullis BR, Welham SJ, Thompson R. ASREML User Guide Release 3.0. 2009.
18. Gulati M, Pandey DK, Arnsdorf MF, Lauderdale DS, Thisted RA, Wicklund RH, Al-Hani AJ, Black HR. Exercise capacity and the risk of death in women: the St James Women Take Heart Project. Circulation 108: 1554-1559, 2003.
19. Haley CS, Knott SA, Elsen JM. Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics 136: 1195-1207, 1994.
20. Hansen C, Spuhler K. Development of the National Institutes of Health genetically heterogeneous rat stock. Alcohol Clin Exp Res 8: 477-479, 1984.
21. Hazel LN. The genetic basis for constructing selection indexes. Genetics 28: 476-490, 1943.
22. Hegmann JP, Possidente B. Estimating genetic correlations from inbred strains. Behav Genet 11: 103-114, 1981.
23. Henderson CR. Best linear unbiased estimation and prediction under a selection model. Biometrics 31: 423-447, 1975.
24. Hill WG, Weir BS. Variation in actual relationship as a consequence of Mendelian sampling and linkage. Genet Res (Camb) 93: 47-64, 2011.
25. Keller MC, Visscher PM, Goddard ME. Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data. Genetics 189: 237-249, 2011.
26. Keller P, Vollaard NB, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, Britton SL, Bouchard C, Koch LG, Timmons JA. A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol 110: 46-59, 2011.
27. Kimura M, Crow JF. On the maximum avoidance of inbreeding. Genet Res 4: 399-415, 1963.
28. Kivela R, Silvennoinen M, Lehti M, Rinnankoski-Tuikka R, Purhonen T, Ketola T, Pullinen K, Vuento M, Mutanen N, Sartor MA, Reunanen H, Koch LG, Britton SL, Kainulainen H. Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB J 24: 4565-4574, 2010.
29. Koch LG, Britton SL. Aerobic metabolism underlies complexity and capacity. J Physiol 586: 83-95, 2008.
30. Koch LG, Britton SL. Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol Genomics 5: 45-52, 2001.
31. Koch LG, Britton SL, Wisloff U. A rat model system to study complex disease risks, fitness, aging, and longevity. Trends Cardiovasc Med 22: 29-34, 2012.
32. Koch LG, Green CL, Lee AD, Hornyak JE, Cicila GT, Britton SL. Test of the principle of initial value in rat genetic models of exercise capacity. Am J Physiol Regul Integr Comp Physiol 288: R466-R472, 2005.
33. Koch LG, Kemi OJ, Qi N, Leng SX, Bijma P, Gilligan LJ, Wilkinson JE, Wisloff H, Hoydal MA, Rolim N, Abadir PM, van Grevenhof EM, Smith GL, Burant CF, Ellingsen O, Britton SL, Wisloff U. Intrinsic aerobic capacity sets a divide for aging and longevity. Circ Res 109: 1162-1172, 2011.
34. Kokkinos P, Myers J, Kokkinos JP, Pittaras A, Narayan P, Manolis A, Karasik P, Greenberg M, Papademetriou V, Singh S. Exercise capacity and mortality in black and white men. Circulation 117: 614-622, 2008.
35. Kruuk LE. Estimating genetic parameters in natural populations using the "animal model". Philos Trans R Soc Lond B Biol Sci 359: 873-890, 2004.
36. Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff P, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG, Goodyear LJ. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes [Epub ahead of print].
37. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346: 793-801, 2002.
38. Paffenbarger RS Jr, Hyde RT, Wing AL, Lee IM, Jung DL, Kampert JB. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med 328: 538-545, 1993.
39. Pedersen BK, Saltin B. Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports 16, Suppl 1: 3-63, 2006.
40. Plum M. Computation of inbreeding and relationship coefficients - in populations with a relatively small number of different male ancestors. J Hered 45: 92-94, 1954.
41. Prud'Homme D, Bouchard C, Leblanc C, Landry F, Fontaine E. Sensitivity of maximal aerobic power to training is genotype-dependent. Med Sci Sports Exerc 16: 489-493, 1984.
42. Schadt EE. Molecular networks as sensors and drivers of common human diseases. Nature 461: 218-223, 2009.
43. Timmons JA. Variability in training-induced skeletal muscle adaptation. J Appl Physiol 110: 846-853, 2011.
44. Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NB, Nielsen S, Akerstrom T, Mac- Dougald OA, Jansson E, Greenhaff PL, Tarnopolsky MA, van Loon LJ, Pedersen BK, Sundberg CJ, Wahlestedt C, Britton SL, Bouchard C. Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol 108: 1487-1496, 2010.
45. Visscher PM, Hill WG, Wray NR. Heritability in the genomics era- concepts and misconceptions. Nat Rev Genet 9: 255-266, 2008.
46. Vollaard NB, Constantin-Teodosiu D, Fredriksson K, Rooyackers O, Jansson E, Greenhaff PL, Timmons JA, Sundberg CJ. Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance. J Appl Physiol 106: 1479-1486, 2009.
47. Walsh B, Blows MW. Abundant genetic variation plus strong selection _ multivariate genetic constraints: a geometric view of adaptation. Annu Rev Ecol Evol S 40: 41-59, 2009.
48. Willis BL, Gao A, Leonard D, Defina LF, Berry JD. Midlife fitness and the development of chronic conditions in later life. Arch Intern Med 1-8, 2012.
49. Wisloff U, Najjar SM, Ellingsen O, Haram PM, Swoap S, Al-Share Q, Fernstrom M, Rezaei K, Lee SJ, Koch LG, Britton SL. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 307: 418-420, 2005.