Interrogating a hexokinase-selected small-molecule library for inhibitors of plasmodium falciparum hexokinase

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 8, 2013, Pages 3731-3737

  Harris, Michael T ^a   Walker, Dawn M ^b   Drew, Mark E ^b   Mitchell, William G ^a   Dao, Kevin ^a   Schroeder, Chad E ^c   Flaherty, Daniel P ^c   Weiner, Warren S ^c   Golden, Jennifer E ^c   Morris, James C ^a  

^a CLEMSON UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BENZOTHIAZOLINE DERIVATIVE; EBSELEN; HEXOKINASE; ISOBENZOTHIAZOLINONE; REDUCING AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIMALARIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DILUTION; ENZYME INACTIVATION; ENZYME INHIBITION; ERYTHROCYTE; GLYCOLYSIS; GROWTH INHIBITION; IC 50; IN VITRO STUDY; MAMMAL; MOLECULAR LIBRARY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTIMALARIALS; AZOLES; BENZOTHIAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLYCOLYSIS; HEXOKINASE; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; ORGANOSELENIUM COMPOUNDS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84880311490     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00662-13     Document Type: Article

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