메뉴 건너뛰기




Volumn 44, Issue SUPPL. 1, 2013, Pages

Ongoing clinical trials in intracerebral hemorrhage

Author keywords

Clinical trial; Intracerebral hemorrhage; Therapy

Indexed keywords

ALTEPLASE; ANTIHYPERTENSIVE AGENT; DEFEROXAMINE; HEMOSTATIC AGENT; PIOGLITAZONE; WARFARIN;

EID: 84880304117     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.000563     Document Type: Conference Paper
Times cited : (22)

References (34)
  • 1
    • 35048839665 scopus 로고    scopus 로고
    • Update on medical and surgical management of intracerebral hemorrhage
    • Cheung RT. Update on medical and surgical management of intracerebral hemorrhage. Rev Recent Clin Trials. 2007;2:174-181.
    • (2007) Rev Recent Clin Trials. , vol.2 , pp. 174-181
    • Cheung, R.T.1
  • 2
    • 0025125821 scopus 로고
    • A prospective study of acute cerebrovascular disease in the community: The oxfordshire community stroke project-1981-86.2 incidence case fatality rates and overall outcome at one year of cerebral infarction primary intracerebral and subarachnoid haemorrhage
    • Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project-1981-86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 1990;53:16-22.
    • (1990) J Neurol Neurosurg Psychiatry. , vol.53 , pp. 16-22
    • Bamford, J.1    Sandercock, P.2    Dennis, M.3    Burn, J.4    Warlow, C.5
  • 3
    • 33846857559 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2007 update: A report from the american heart association statistics committee and stroke statistics subcommittee
    • American Heart Association Statistics Committee And Stroke Statistics Subcommittee
    • Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, et al American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115:e69-e171.
    • (2007) Circulation. , vol.115
    • Rosamond, W.1    Flegal, K.2    Friday, G.3    Furie, K.4    Go, A.5    Greenlund, K.6
  • 4
    • 29044441975 scopus 로고    scopus 로고
    • Mechanisms of brain injury after intracerebral haemorrhage
    • Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006;5:53-63.
    • (2006) Lancet Neurol. , vol.5 , pp. 53-63
    • Xi, G.1    Keep, R.F.2    Hoff, J.T.3
  • 5
    • 79960766569 scopus 로고    scopus 로고
    • Treatment targets in intracerebral hemorrhage
    • Sangha N, Gonzales NR. Treatment targets in intracerebral hemorrhage. Neurotherapeutics. 2011;8:374-387.
    • (2011) Neurotherapeutics. , vol.8 , pp. 374-387
    • Sangha, N.1    Gonzales, N.R.2
  • 8
    • 0031748498 scopus 로고    scopus 로고
    • Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage
    • Fujii Y, Takeuchi S, Sasaki O, Minakawa T, Tanaka R. Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage. Stroke. 1998;29:1160-1166.
    • (1998) Stroke. , vol.29 , pp. 1160-1166
    • Fujii, Y.1    Takeuchi, S.2    Sasaki, O.3    Minakawa, T.4    Tanaka, R.5
  • 9
    • 33747197463 scopus 로고    scopus 로고
    • Lack of evidence for an association between hemodynamic variables and hematoma growth in spontaneous intracerebral hemorrhage
    • Jauch EC, Lindsell CJ, Adeoye O, Khoury J, Barsan W, Broderick J, et al. Lack of evidence for an association between hemodynamic variables and hematoma growth in spontaneous intracerebral hemorrhage. Stroke. 2006;37:2061-2065.
    • (2006) Stroke. , vol.37 , pp. 2061-2065
    • Jauch, E.C.1    Lindsell, C.J.2    Adeoye, O.3    Khoury, J.4    Barsan, W.5    Broderick, J.6
  • 10
    • 11144234974 scopus 로고    scopus 로고
    • Cerebrovascular Diseases Group of the Spanish Neurological Society. Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage
    • Silva Y, Leira R, Tejada J, Lainez JM, Castillo J, Dávalos A; Stroke Project, Cerebrovascular Diseases Group of the Spanish Neurological Society. Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage. Stroke. 2005;36:86-91.
    • (2005) Stroke. , vol.36 , pp. 86-91
    • Silva, Y.1    Leira, R.2    Tejada, J.3    Lainez, J.M.4    Castillo, J.5    Dávalos, A.6    Project, S.7
  • 11
    • 41949133660 scopus 로고    scopus 로고
    • Intensive blood pressure reduction in acute cerebral haemorrhage trial (interact): A randomised pilot trial
    • INTERACT Investigators
    • Anderson CS, Huang Y, Wang JG, Arima H, Neal B, Peng B, et al INTERACT Investigators. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol. 2008;7:391-399.
    • (2008) Lancet Neurol. , vol.7 , pp. 391-399
    • Anderson, C.S.1    Huang, Y.2    Wang, J.G.3    Arima, H.4    Neal, B.5    Peng, B.6
  • 12
    • 74949111125 scopus 로고    scopus 로고
    • Antihypertensive treatment of acute cerebral hemorrhage
    • Qureshi AI. Antihypertensive treatment of acute cerebral hemorrhage. Crit Care Med. 2010;38:637-648
    • (2010) Crit Care Med. , vol.38 , pp. 637-648
    • Qureshi, A.I.1
  • 15
    • 13844315293 scopus 로고    scopus 로고
    • Recombinant activated factor vii intracerebral hemorrhage trial investigators. Recombinant activated factor vii for acute intracerebral hemorrhage
    • Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, et al Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005;352:777-785.
    • (2005) N Engl J Med. , vol.352 , pp. 777-785
    • Mayer, S.A.1    Brun, N.C.2    Begtrup, K.3    Broderick, J.4    Davis, S.5    Diringer, M.N.6
  • 16
    • 43549087410 scopus 로고    scopus 로고
    • Fast trial investigators. Efficacy and safety of recombinant activated factor vii for acute intracerebral hemorrhage
    • Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, et al FAST Trial Investigators. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008;358:2127-2137.
    • (2008) N Engl J Med. , vol.358 , pp. 2127-2137
    • Mayer, S.A.1    Brun, N.C.2    Begtrup, K.3    Broderick, J.4    Davis, S.5    Diringer, M.N.6
  • 17
    • 70349260801 scopus 로고    scopus 로고
    • Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion: The spot sign score
    • Delgado Almandoz JE, Yoo AJ, Stone MJ, Schaefer PW, Goldstein JN, Rosand J, et al. Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion: the spot sign score. Stroke. 2009;40:2994-3000.
    • (2009) Stroke. , vol.40 , pp. 2994-3000
    • Delgado Almandoz, J.E.1    Yoo, A.J.2    Stone, M.J.3    Schaefer, P.W.4    Goldstein, J.N.5    Rosand, J.6
  • 18
    • 84858618556 scopus 로고    scopus 로고
    • Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the ct-angiography spot sign (predict): A prospective observational study
    • PREDICT/Sunnybrook ICH CTA study group
    • Demchuk AM, Dowlatshahi D, Rodriguez-Luna D, Molina CA, Blas YS, Dzialowski I, et al; PREDICT/Sunnybrook ICH CTA study group. Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study. Lancet Neurol. 2012;11:307-314.
    • (2012) Lancet Neurol. , vol.11 , pp. 307-314
    • Demchuk, A.M.1    Dowlatshahi, D.2    Rodriguez-Luna, D.3    Molina, C.A.4    Blas, Y.S.5    Dzialowski, I.6
  • 20
    • 84880292296 scopus 로고    scopus 로고
    • Spot sign" selection of intracerebral hemorrhage to guide hemostatic therapy (spotlight) [online
    • Bethesda (MD): National Library of Medicine (US). [cited 2012 Dec19]. Available at
    • Gladstone DJ. "Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy (SPOTLIGHT) [online]. In: ClinicalTrials. gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited 2012 Dec19]. Available at: http://clinicaltrials.gov/ct2/show/NCT01359202.
    • (2000) ClinicalTrials. gov [Internet
    • Gladstone, D.J.1
  • 21
    • 0031797853 scopus 로고    scopus 로고
    • Surgical treatment for intracerebral hemorrhage (stich): A single-center, randomized clinical trial
    • Morgenstern LB, Frankowski RF, Shedden P, Pasteur W, Grotta JC. Surgical treatment for intracerebral hemorrhage (STICH): a single-center, randomized clinical trial. Neurology. 1998;51:1359-1363.
    • (1998) Neurology. , vol.51 , pp. 1359-1363
    • Morgenstern, L.B.1    Frankowski, R.F.2    Shedden, P.3    Pasteur, W.4    Grotta, J.C.5
  • 22
    • 13144256723 scopus 로고    scopus 로고
    • Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the international surgical trial in intracerebral haemorrhage (stich): A randomised trial
    • STICH investigators
    • Mendelow AD, Gregson BA, Fernandes HM, Murray GD, Teasdale GM, Hope DT, et al; STICH investigators. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet. 2005;365:387-397.
    • (2005) Lancet. , vol.365 , pp. 387-397
    • Mendelow, A.D.1    Gregson, B.A.2    Fernandes, H.M.3    Murray, G.D.4    Teasdale, G.M.5    Hope, D.T.6
  • 23
    • 0035933052 scopus 로고    scopus 로고
    • Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage
    • Morgenstern LB, Demchuk AM, Kim DH, Frankowski RF, Grotta JC. Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage. Neurology. 2001;56:1294-1299.
    • (2001) Neurology. , vol.56 , pp. 1294-1299
    • Morgenstern, L.B.1    Demchuk, A.M.2    Kim, D.H.3    Frankowski, R.F.4    Grotta, J.C.5
  • 24
    • 84880258892 scopus 로고    scopus 로고
    • Surgical trial in lobar intracerebral hemorrhage [online]
    • Bethesda (MD): National Library of Medicine (US). 2000 [ cited 2012 Dec 19]. Available at
    • Mendelow AD. Surgical trial in lobar intracerebral hemorrhage [online]. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [ cited 2012 Dec 19].Available at: http://www.clinicaltrials.gov/ show/NCT01320423.
    • ClinicalTrials.gov [Internet
    • Mendelow, A.D.1
  • 25
    • 84880314944 scopus 로고    scopus 로고
    • Abstract 3022: Image-guided endoscopic evacuation of spontaneous intracerebral hemorrhage
    • Dusick JR, Dye J, Gonzalez N, Varma J, Frazee J, Vespa PM, et al. Abstract 3022: Image-guided endoscopic evacuation of spontaneous intracerebral hemorrhage. Stroke. 2012;43:A3022
    • (2012) Stroke. , vol.43
    • Dusick, J.R.1    Dye, J.2    Gonzalez, N.3    Varma, J.4    Frazee, J.5    Vespa, P.M.6
  • 26
    • 84880296415 scopus 로고    scopus 로고
    • Mis+rtpa for ich evacuation
    • Bethesda (MD): National Library of Medicine (US). [cited 2012 Dec 19] Available at
    • Hanley D. MIS+rtPA for ICH Evacuation. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited 2012 Dec 19] Available at: http://clinicaltrials.gov/ct2/show/NCT00224770.
    • (2000) ClinicalTrialsgov [Internet
    • Hanley, D.1
  • 27
    • 34247560648 scopus 로고    scopus 로고
    • Hematoma resolution as a target for intracerebral hemorrhage treatment: Role for peroxisome proliferator-activated receptor gamma in microglia/macrophages
    • Zhao X, Sun G, Zhang J, Strong R, Song W, Gonzales N, et al. Hematoma resolution as a target for intracerebral hemorrhage treatment: Role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. Ann Neurol. 2007;61:352-362.
    • (2007) Ann Neurol. , vol.61 , pp. 352-362
    • Zhao, X.1    Sun, G.2    Zhang, J.3    Strong, R.4    Song, W.5    Gonzales, N.6
  • 28
    • 84879466173 scopus 로고    scopus 로고
    • Design of a prospective, dose-escalation study evaluating the safety of pioglitazone for hematoma resolution in intracerebral hemorrhage (shrinc)
    • February 12, doi: 10.1111/j.1747-4949.2011.00761.x.
    • Gonzales NR, Shah J, Sangha N, Sosa L, Martinez R, Shen L, et al. Design of a prospective, dose-escalation study evaluating the Safety of Pioglitazone for Hematoma Resolution in Intracerebral Hemorrhage (SHRINC). Int J Stroke. February 12, 2012. doi: 10.1111/j.1747-4949.2011.00761.x.
    • (2012) Int J Stroke
    • Gonzales, N.R.1    Shah, J.2    Sangha, N.3    Sosa, L.4    Martinez, R.5    Shen, L.6
  • 29
    • 80055001133 scopus 로고    scopus 로고
    • Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage
    • Deferoxamine Mesylate in Intracerebral Hemorrhage Investigators
    • Selim M, Yeatts S, Goldstein JN, Gomes J, Greenberg S, Morgenstern LB, et al; Deferoxamine Mesylate in Intracerebral Hemorrhage Investigators. Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage. Stroke. 2011;42:3067-3074.
    • (2011) Stroke. , vol.42 , pp. 3067-3074
    • Selim, M.1    Yeatts, S.2    Goldstein, J.N.3    Gomes, J.4    Greenberg, S.5    Morgenstern, L.B.6
  • 30
    • 84880303111 scopus 로고    scopus 로고
    • High-dose deferoxamine in intracerebral hemorrhage (hi-def)
    • Bethesda (MD): National Library Of Medicine (US). [cited 2012 Oct 29]. Available at
    • Selim M. High-Dose Deferoxamine in Intracerebral Hemorrhage (HI-DEF) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited 2012 Oct 29]. Available at: http://clinicaltrials.gov/ct2/show/ NCT01662895.
    • (2000) ClinicalTrials.gov [Internet
    • Selim, M.1
  • 31
    • 80054974583 scopus 로고    scopus 로고
    • Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: The intraventricular hemorrhage thrombolysis trial
    • Naff N, Williams MA, Keyl PM, Tuhrim S, Bullock MR, Mayer SA, et al. Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial. Stroke. 2011;42:3009-3016.
    • (2011) Stroke. , vol.42 , pp. 3009-3016
    • Naff, N.1    Williams, M.A.2    Keyl, P.M.3    Tuhrim, S.4    Bullock, M.R.5    Mayer, S.A.6
  • 32
    • 80054983540 scopus 로고    scopus 로고
    • Clear intraventricular hemorrhage: More than a glimmer of hope
    • Mattle HP, Raabe A. CLEAR intraventricular hemorrhage: more than a glimmer of hope. Stroke. 2011;42:2999-3000.
    • (2011) Stroke. , vol.42 , pp. 2999-3000
    • Mattle, H.P.1    Raabe, A.2
  • 33
    • 84880290465 scopus 로고    scopus 로고
    • Clot lysis: Evaluating accelerated resolution of intraventricular hemorrhage phase iii (clear iii)
    • [Internet]. Bethesda (MD): National Library Of Medicine 9US). [2012 Oct 29] Available at
    • Hanley D. Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR III) In: ClinicalTrials. gov [Internet]. Bethesda (MD): National Library of Medicine 9US). 2000 [2012 Oct 29] Available at: http://clinicaltrials.gov/ct2/show/NCT00784134.
    • (2000) ClinicalTrials. Gov
    • Hanley, D.1
  • 34
    • 84880313689 scopus 로고    scopus 로고
    • International normalized ratio (inr) normalization in coumadin associated intracerebral haemorrhage (inch)
    • [Internet]. Bethesda (MD): National Library Of Medicine (US). [cited 2012 Oct 31]. Available at
    • Steiner T. International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage (INCH) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited 2012 Oct 31]. Available at: http://clinicaltrials.gov/ct2/show/NCT00928915.
    • (2000) ClinicalTrials.gov
    • Steiner, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.