Glucosamine induces activated T cell apoptosis through reduced T cell receptor

Scandinavian Journal of Immunology

Volumn 78, Issue 1, 2013, Pages 17-27

  Chen, N H ^a   Cheong, K A ^a   Kim, C H ^a   Noh, M ^b   Lee, A Y ^a  

^a Dongguk University Ilsan Hospital   (South Korea)

^b Ajou University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CD3 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOSAMINE; GLYCAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CD3+ T LYMPHOCYTE; CONTROLLED STUDY; DERMATITIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN DEFECT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; CTLA-4 ANTIGEN; GLUCOSAMINE; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MALE; MICE; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 84880303912     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12056     Document Type: Article

References (34)

1. Brief AA, Maurer SG, Di Cesare PE. Use of glucosamine and chondroitin sulfate in the management of osteoarthritis. J Am Acad Orthop Surg 2001;9:71-8.
2. Ma LL, Rudert WA, Harnaha J et al. Immunosuppressive effects of glucosamine. J Biol Chem 2002;277:39343-9.
3. Wang Z, Liang R, Huang GS et al. Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL. Apoptosis 2006;11:1851-60.
4. Hwang MS, Baek WK. Glucosamine induces autophagic cell death through the stimulation of ER stress in human glioma cancer cells. Biochem Biophys Res Commun 2010;399:111-6.
5. Wu YL, Kou YR, Ou HL et al. Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol 2010;635:219-26.
6. Forchhammer L, Thorn M, Met O, Gad M, Weidner MS, Claesson MH. Immunobiological effects of glucosamine in vitro. Scand J Immunol 2003;58:404-11.
7. Zhang GX, Yu S, Gran B, Rostami A. Glucosamine abrogates the acute phase of experimental autoimmune encephalomyelitis by induction of Th2 response. J Immunol 2005;175:7202-8.
8. Kim CH, Cheong KA, Park CD, Lee AY. Glucosamine improved atopic dermatitis-like skin lesions in NC/Nga mice by inhibition of Th2 cell development. Scand J Immunol 2011;73:536-45.
9. Morgan R, Gao G, Pawling J, Dennis JW, Demetriou M, Li B. N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. J Immunol 2004;173:7200-8.
10. Grigorian A, Lee SU, Tian W et al. Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem 2007;282:20027-35.
11. Alegre ML, Frauwirth KA, Thompson CB. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol 2001;1:220-8.
12. Demetriou M, Granovsky M, Quaggin S, Dennis JW. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 2001;409:733-9.
13. Mogil RJ, Radvanyi L, Gonzalez-Quintial R et al. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int Immunol 1995;7:1451-8.
14. Lu B, Wang LY, Stehlik C et al. Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells. J Immunol 2006;176:6785-93.
15. Fulda S, Strauss G, Meyer E, Debatin KM. Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells. Blood 2000;95:301-8.
16. Gross A, Yin XM, Wang K et al. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 1999;274:1156-63.
17. Singh R, Pervin S, Chaudhuri G. Caspase-8-mediated BID cleavage and release of mitochondrial cytochrome c during Nomega-hydroxy-l-arginine-induced apoptosis in MDA-MB-468 cells. Antagonistic effects of L-ornithine. J Biol Chem 2002;277:37630-6.
18. Li TF, Lu CZ, Xia ZL, Xiao BG, Luo YM. Inhibition of caspase-8 attenuates neuronal death induced by limbic seizures in a cytochrome c-dependent and Smac/DIABLO-independent way. Brain Res 2006;1098:204-11.
19. Toyoshima F, Moriguchi T, Nishida E. Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases. J Cell Biol 1997;139:1005-15.
20. Desbarats J, Birge RB, Mimouni-Rongy M, Weinstein DE, Palerme JS, Newell MK. Fas engagement induces neurite growth through ERK activation and p35 upregulation. Nat Cell Biol 2003;5:118-25.
21. Kreuz S, Siegmund D, Rumpf JJ et al. NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. J Cell Biol 2004;166:369-80.
22. Lavrik IN, Golks A, Riess D, Bentele M, Eils R, Krammer PH. Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J Biol Chem 2007;282:13664-71.
23. Gulbins E, Hermisson M, Brenner B et al. Cellular stimulation via CD95 involves activation of phospho-inositide-3-kinase. Pflugers Arch 1998;435:546-54.
24. Pastorino JG, Tafani M, Farber JL. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway. J Biol Chem 1999;274:19411-6.
25. La Rosa FA, Pierce JW, Sonenshein GE. Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors. Mol Cell Biol 1994;14:1039-44.
26. Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992;71:649-62.
27. Yamamoto M, Haruna T, Yasui K et al. A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice. Allergol Int 2007;56:139-48.
28. Irving BA, Weiss A. The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 1991;64:891-901.
29. Romeo C, Amiot M, Seed B. Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain. Cell 1992;68:889-97.
30. Wegener AM, Letourneur F, Hoeveler A, Brocker T, Luton F, Malissen B. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 1992;68:83-95.
31. Qian D, Mollenauer MN, Weiss A. Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J Exp Med 1996;183:611-20.
32. Sareneva T, Matikainen S, Vanhatalo J, Melén K, Pelkonen J, Julkunen I. Kinetics of cytokine and NFAT gene expression in human interleukin-2-dependent T lymphoblasts stimulated via T-cell receptor. Immunology 1998;93:350-7.
33. Kastan MB, Kuerbitz SJ. Control of G1 arrest after DNA damage. Environ Health Perspect 1993;101:55-8.
34. May MJ, Ghosh S. Signal transduction through NF-kappa B. Immunol Today 1998;19:80-8.