Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease

Obesity Research and Clinical Practice

Volumn 7, Issue 4, 2013, Pages

  Pirgon, Ozgur ^a   Cekmez, Ferhat ^b   Bilgin, Huseyin ^a   Eren, Esra ^a   Dundar, Bumin ^c  

^a Medicana Konya Hospital   (Turkey)

^b GULHANE SCHOOL OF MEDICINE   (Turkey)

^c SULEYMAN DEMIREL UNIVERSITY   (Turkey)

Author keywords

25 Hydroxyvitamin D; Adolescent; Insulin resistance; Non alcoholic fatty liver disease; Obesity

Indexed keywords

25 HYDROXYVITAMIN D; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CALCIUM; CREATININE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAGNESIUM; PARATHYROID HORMONE; PHOSPHATE; TRIACYLGLYCEROL;

ADOLESCENT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; BODY MASS; CALCIUM BLOOD LEVEL; CHILD; CHILDHOOD OBESITY; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAGNESIUM BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL;

ADOLESCENT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BLOOD PRESSURE; BODY MASS INDEX; BODY WEIGHT; CASE-CONTROL STUDIES; CHILD; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FATTY LIVER; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; MALE; PEDIATRIC OBESITY; RISK FACTORS; VITAMIN D;

EID: 84880298486     PISSN: 1871403X     EISSN: 18780318     Source Type: Journal    
DOI: 10.1016/j.orcp.2012.01.004     Document Type: Article

References (45)

1. N.J. Barshop, C.B. Sirlin, J.B. Schwimmer, and J.E. Lavine Review article: epidemiology, pathogenesis and potential treatments of paediatric nonalcoholic fatty liver disease Aliment Pharmacol Ther 28 1 2008 13 24
2. A. Fraser, M.P. Longnecker, and D.A. Lawlor Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004 Gastroenterology 133 6 2007 1814 1820
3. J.B. Meigs Insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors Am J Epidemiol 152 10 2000 908 911
4. G. Marchesini, E. Bugianesi, G. Forlani, F. Cerrelli, M. Lenzi, and R. Manini Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome Hepatology 37 2 2003 917 923
5. B.J. Boucher Inadequate vitamin D status: does it contribute to the disorders comprising syndrome X? Br J Nutr 794 1998 315 327
6. R. Scragg, R. Jackson, I. Holdaway, T. Lim, and R. Beaglehole Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study Int J Epidemiol 19 3 1990 559 563
7. N.G. Forouhi, J. Luan, A. Cooper, B.J. Boucher, and N.J. Wareham Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000 Diabetes 57 10 2008 2619 2625
8. F.M. Cizmecioglu, N. Etiler, U. Gormus, O. Hamzaoglu, and S. Hatun Hypovitaminosis D in obese and overweight schoolchildren J Clin Res Pediatr Endocrinol 1 2 2008 89 96
9. J. Hjelmesaeth, D. Hofsø, E.T. Aasheim, T. Jenssen, J. Moan, and H. Hager Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study Cardiovasc Diabetol 8 1 2009 1 7
10. K. Katz, P.C. Brar, N. Parekh, Y.H. Liu, and M. Weitzman Suspected nonalcoholic fatty liver disease is not associated with vitamin d status in adolescents after adjustment for obesity J Obes 2010 2010 496829
11. K.C. Chiu, A. Chu, V.L. Go, and M.F. Saad Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction Am J Clin Nutr 79 5 2004 820 825
12. P.T. Kumar, S. Antony, M.S. Nandhu, J. Sadanandan, G. Naijil, and C.S. Paulose Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats J Nutr Biochem 22 5 2011 418 425
13. A.P. Mee, L.K. Davenport, J.A. Hoyland, M. Davies, and E.B. Mawer Novel and sensitive detection systems for the vitamin D receptor - in situ-reverse transcriptase-polymerase chain reaction and immunogold cytochemistry J Mol Endocrinol 16 2 1996 183 195
14. M.E. Sandgren, M. Brönnegärd, and H.F. DeLuca Tissue distribution of the 1,25-dihydroxy vitamin D3 receptor in the male rat Biochem Biophys Res Commun 181 2 1991 611 616
15. I. Barchetta, F. Angelico, M. Del Ben, M.G. Baroni, P. Pozzilli, and S. Morini Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes BMC Med 9 2011 85
16. A. Ozturk, M.M. Mazicioglu, N. Hatipoglu, N. Budak, G. Keskin, and Z. Yazlak Reference body mass index curves for Turkish children 6 to 18 years of age J Pediatr Endocrinol Metab 21 9 2008 827 836
17. M.F. Holick, and D. Vitamin importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis Am J Clin Nutr 79 5 2004 362 371
18. L. Mosekilde Vitamin Dx and the elderly Clin Endocrinol (Oxf) 62 3 2005 265 281
19. A.A. Ginde, M.C. Liu, and C.A. Camargo Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004 Arch Intern Med 169 6 2009 626 632
20. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in men Diabetologia 28 7 1985 412 419
21. M. Keskin, S. Kurtoglu, M. Kendirci, M.E. Atabek, and C. Yazici Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents Pediatrics 115 4 2005 500 503
22. A. Alisi, M. Manco, A. Vania, and V. Nobili Pediatric nonalcoholic fatty liver disease in 2009 J Pediatr 155 4 2009 469 474
23. K. Tominaga, J.H. Kurata, Y.K. Chen, E. Fujimoto, S. Miyagawa, and I. Abe Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey Dig Dis Sci 40 9 1995 2002 2009
24. C.H. Stephen, H.L. Tri, and M.A. Stacey Non alcoholic steatohepatitis Textbook. Schiff's diseases of liver 9th ed. 2002 Lippincott William & Wilkins Philadelphia, PA p. 1261-89
25. C.M. Gordon, K.C. DePeter, H.A. Feldman, E. Grace, and S.J. Emans Prevalence of vitamin D deficiency among healthy adolescents Arch Pediatr Adolesc Med 158 6 2004 531 537
26. G. Targher, L. Bertolini, L. Scala, M. Cigolini, L. Zenari, and G. Falezza Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease Nutr Metab Cardiovasc Dis 17 7 2007 517 524
27. J.S. Ko, J.M. Yoon, H.R. Yang, J.K. Myung, H. Kim, and G.H. Kang Clinical and histological features of nonalcoholic fatty liver disease in children Dig Dis Sci 54 10 2009 2225 2230
28. G. Radetti, W. Kleon, J. Stuefer, and K. Pittschieler Non-alcoholic fatty liver disease in obese children evaluated by magnetic resonance imaging Acta Paediatr 95 9 2006 833 837
29. D.F. Chan, A.M. Li, W.C. Chu, M.H. Chan, E.M. Wong, and E.K. Liu Hepatic steatosis in obese Chinese children Int J Obes Relat Metab Disord 28 10 2004 1257 1263
30. L. Lu, Z. Yu, A. Pan, F.B. Hu, O.H. Franco, and H. Li Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals Diabetes Care 32 7 2009 1278 1283
31. O. Selberg, W. Burchert, J. vd Hoff, G.J. Meyer, H. Hundeshagen, and E. Radoch Insulin resistance in liver cirrhosis. Positron-emission tomography scan analysis of skeletal muscle glucose metabolism J Clin Invest 91 5 1993 1897 1902
32. E. Imano, T. Kanda, Y. Nakatani, M. Motomura, K. Arai, and M. Matsuhisa Impaired splanchnic and peripheral glucose uptake in liver cirrhosis J Hepatol 31 3 1999 413 469
33. M.F. McCarty Secondary hyperparathyroidism promotes the acute phase responseda rationale for supplemental vitamin D in prevention of vascular events in the elderly Med Hypotheses 64 5 2005 1022 1026
34. O. Gedik, and S. Akalin Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man Diabetologia 29 3 1986 142 145
35. B. Maestro, N. Dávila, M.C. Carranza, and C. Calle Identification of a vitamin D response element in the human insulin receptor gene promoter J Steroid Biochem Mol Biol 84 2-3 2003 223 230
36. W.J. Kong, H. Zhang, D.Q. Song, R. Xue, W. Zhao, and J. Wei Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression Metabolism 58 1 2009 109 119
37. H. Zhang, J. Wei, R. Xue, J.D. Wu, W. Zhao, and Z.Z. Wang Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression Metabolism 59 2 2010 285 292
38. R. Selvam, and C.V. Anuradha Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan-induced diabetic rats J Nutr Biochem 1 12 1990 653 658
39. A. Ashraf, J. Alvarez, K. Saenz, B. Gower, K. McCormick, and F. Franklin Threshold for effects of vitamin D deficiency on glucose metabolism in obese female African-American adolescents J Clin Endocrinol Metab 94 9 2009 3200 3206
40. M. Manco, P. Ciampalini, and V. Nobili Low levels of 25-hydroxyvitamin D(3) in children with biopsy-proven nonalcoholic fatty liver disease Hepatology 51 4 2010 2229
41. R. Scragg, I. Holdaway, V. Singh, P. Metcalf, J. Baker, and E. Dryson Serum 25-hydroxy vitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus Diabetes Res Clin Pract 27 3 1995 181 188
42. B.J. Boucher, N. Mannan, K. Noonan, C.N. Hales, and S.J. Evans Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians Diabetologia 38 10 1995 1239 1245
43. N. George, T. Peeyush Kumar, S. Antony, S. Jayanarayanan, and C.S. Paulose Effect of vitamin D3 in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats Br J Nutr 107 6 2012 1 9
44. M.H. Fishbein, M. Miner, C. Mogren, and J. Chalekson The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis J Pediatr Gastroenterol Nutr 36 1 2003 54 61
45. P. Mofrad, M.J. Contos, M. Haque, C. Sargeant, R.A. Fisher, and V.A. Luketic Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values Hepatology 37 6 2003 1286 1292