Evaluation of brain targeting and mucosal integrity of nasally administrated nanostructured carriers of a CNS active drug, clonazepam

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 16, Issue 3, 2013, Pages 456-469

  Abdel Bar, Hend Mohamed ^a   Abdel Reheem, Amal Youssef ^a   Awad, Gehanne Abdel Samie ^b   Mortada, Nahed Daoud ^b  

^a NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

^b AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CLONAZEPAM; CREMOPHOR; MACROGOL 200; MYRISTIC ACID ISOPROPYL ESTER; NANOCARRIER; PHOSPHATIDYLCHOLINE; POLYSORBATE 80; PROPYLENE GLYCOL; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; DRUG STABILITY; DRUG TARGETING; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; NOSE MUCOSA; PARTICLE SIZE; POLARIZATION MICROSCOPY; RAT; VISCOSITY;

EID: 84880290927     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j30s31     Document Type: Article

References (43)

1. Bernacki J, Dobrowolska A, Nierwińska K, Małecki A. Physiology and pharmacological role of the blood-brain barrier. Pharmacol Rep, 2008;60(5): 600-22.
2. Sakane T, Tanaka C, Yamamoto A, Hashida M, Sezaki H, Ueda H. The effect of polysorbate 80 on brain uptake and analgesic effect of D-kyotorphin. Int J Pharm, 1989; 57:77-83.
3. Narang AS, Delmarre D, Gao D. Drug encapsulation in micelles and microemulsions. Int J Pharm, 2007; 345:9-25.
4. Gupta U, Jain NK. Non-polymeric nano-carriers in HIV/AIDS drug delivery and targeting. Advanced Drug Delivery Reviews, 2010; 62:478-490.
5. Kumar A, Sharma P, Chaturvedi A, Jaiswal D, Bajpai M, Choudhary M, et al. Formulation development of sertraline hydrochloride microemulsion for intranasal delivery. International Journal of ChemTech Research,2009; 1(4):941-947.
6. Wilson Quevedo, Marcel Petri, Gerhard Busse, and Simone Techert. On the mechanism of photoinduced phase transitions in ternary liquid crystal systems near thermal equilibrium. The Journal of Chemical Physics, 2008; 129(024502):1-10.
7. Yao J, Zhou JP, Ping QN, Lu Y, Chen L. Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice. Int J Pharm, 2008; 352:256-262.
8. Be'duneau A, Saulnier P, Benoit JP. Active targeting of brain tumors using nanocarriers. Biomaterials, 2007; 28: 4947-4967.
9. Nielsen L.S., Lene Schubert, Jens Hansen. Bioadhesive drug delivery systems: I. Characterisation of mucoadhesive properties of systems based on glyceryl mono-oleate and glyceryl monolinoleate. Eur. J. Pharm. Sci, 1998; 6:231-239.
10. Chung H., Kim J., Um Y.J., Kwon I.C., Jeong S.Y. Self-assembled" nanocubicle" as a carrier for peroral insulin delivery. Diabetologia, 2002; 45:448-451.
11. Patel P.V., Patel J.B., Dangar R.D., Patel K.S., Chauhan K. N. Liquid Crystal Drug Delivery System. International Journal of Pharmaceutical and Applied Sciences, 2010; 1:118-123.
12. Chang C.-M., Bodmeier R. Low viscosity monoglyceride-based drug delivery systems transforming into a highly viscous cubic phase. Int. J. Pharm, 1998; 173:51-60.
13. Costantino HR, Illum L, Brandt G, Johnson PH, Quay SC. Intranasal delivery: Physicochemical and therapeutic aspects.Int J Pharm,2007; 337:1-24.
14. Li L, Nandi I, Kim KH. Development of an ethyl laurate-based microemulsion for rapid-onset intranasal delivery of diazepam. Int J Pharm, 2002; 237:77-85.
15. Zaki NM, Awad GAS, Mortada ND, Abd ElHady SS. Rapid-onset intranasal delivery of metoclopramide hydrochloride: Part I. Influence of formulation variables on drug absorption in anesthetized rats. Int J Pharm, 2006; 327: 89-96.
16. Arumugam K., Subramanian GS., Mallayasamy S R., Averineni R K., Reddy M S., Udupa N. A study of rivastigmine liposomes for delivery into the brain through intranasal route. Acta Pharm, 2008; 58: 287-297.
17. Pardridge WM. Blood-brain barrier delivery. Drug Discov Today, 2007; 12(1/2):54-61.
18. Candace LG, Pollock GM. Nasal Drug administration: potential for targeted central nervous system delivery. J Pharm Sci, 2005; 94:187-195.
19. Cartt S, Medeiros D. Wilson Sonsini Goodrich & Rosati. 2007. IPC8 Class: AA61K912FI and USPC Class: 42443.
20. Aboofazeli R, Lawrence MJ. Investigations into the formation and characterization of phospholipid microemulsions. II. Pseudo-ternary phase diagrams of systems containing water-lecithinisopropyl myristate and alcohol: influence of purity of lecithin. Int J Pharm,1994; 106:51-61.
21. Zhang P, Liu Y, Feng N, Xu J. Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm, 2008; 355: 269-276.
22. Niels Mygind and Ronald Dahl. Anatomy, physiology and function of the nasal cavities in health and disease. Advanced Drug Delivery Reviews, 1998; 29(1-2): 3-12.
23. Peppas, N.A. Analysis of fickian and non-fickian drug release from polymers. Pharm Acta Helv, 1985; 60: 110-111.
24. Vyas TK, Babbar AK, Sharma RK, Singh S, Misra A. Intranasal Mucoadhesive Microemulsions of Clonazepam: Preliminary Studies on Brain Targeting. J Pharm Sc, 2006; 95:1-11.
25. Wagner JG, Nelson E. Percent absorbed time plots derived from blood level and/or urinary excretion data. J Pharm Sci, 1963; 52:610-611.
26. Miyamoto, M., Natsume, H., Iwata, S., Ohtake, K., Yamaguchi, M., Kobayashi, D., Sugibayashi, K., Yamashina, M., Morimoto, Y. Improved nasal absorption of drug using poly-l-arginine: Effect of concentration and molecular weight poly-L-arginine on the nasal absorption of FITC-dextran in rats, Eur. J. Pharm. Biopharm. 2001; 52: 21-30.
27. Banchroft, J.D.; Stevens, A. and Turner, D.R. THEORY AND PRACTICE OF HISTOLOICL TECHNIQUES. 1996: Fourth Ed. Churchil Livingstone, New york, London, San Francisco, Tokyo.
28. Yuan J. Estimation of variance for AUC in animal studies. J Pharm Sci 1993; 82: 781-783.
29. Shah VP, Tsong Y, Sathe P, Liu JP. In vitro dissolution profile comparison - statistics and analysis of the similarity factor. Pharm Res, 1998; 15: 889-896.
30. Moreno MA, Ballesteros MP, Frutos P. Lecithinbased oil-in-water microemulsions for parenteral use: pseudo ternary phase diagrams, characterization and toxicity studies. J Pharm Sci, 2003; 92: 1428-1437.
31. Paolino D, Massimo F. Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability. Int J Pharm, 2002; 244:21-31.
32. Kumar R, Katare OP. Lecithin Organogels as a Potential Phospholipid-Structured System for Topical Drug Delivery: A Review AAPS PharmSciTech, 2005; 6 (2):E298-E310.
33. Boonme P, Krauel K, Graf A, Rades T, Junyaprasert VB. Characterization of Microemulsion Structures in the Pseudoternary Phase Diagram of Isopropyl Palmitate/Water/Brij 97:1-Butanol. AAPS PharmSciTech, 2006; 7 (2) Article 45: E1-E6.
34. Kumar M, Misra A, Babbar AK, Mishra AK, Mishra P, Pathak K. Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm, 2008;358: 285-291
35. Gupta S, Brouwer P, Bandyopadhyay S, Patil S, Briggs R, Jain J, Seal S. TEM/AFM Investigation of Size and Surface Properties of Nanocrystalline Ceria. Journal of Nanoscience and Nanotechnology, 2005; 5: 1101-1107.
36. Mistry A, Stolnik S, Illum L. Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm, 2009; 379: 146-157.
37. Alany RG, Tucker IG, Davies NM, Rades T. Characterizing colloidal structures of pseudoternary phase diagrams formed by oil/water/ amphiphile systems. Drug Dev Ind Pharm, 2001;27:31-38.
38. Garti N, Aserin A, Tiunova I, Fanun M. A DSC study of water behavior in water-in-oil microemulsions stabilized by sucrose esters and butanol. Colloids Surf A, 2000;170:1-18.
39. Resende KX, Corrêa MA, de Oliveira AG, Scarpa MV. Effect of cosurfactant on the supramolecular structure and physicochemical properties of nonionic biocompatible microemulsions. Brazilian J Pharm Sc, 2008; 44(1): 35-42
40. Illum L. Transport of drugs from nasal cavity to central nervous system. Eur J Pharm Sci, 2000; 11: 1-18.
41. Illum L. Nasal drug delivery: problems, possibilities and solutions. J Controlled Rel, 2003; 87: 187-198.
42. Vyas TK, Shahiwala A, Marathe S, Misra A. Intranasal drug delivery for brain targeting. Curr Drug Deliv, 2005; 2: 165-175.
43. Choi Yong Moon, Li Lianli, Kim Kwon H. Transnasal anticonvulsive compositions and modulated process. United States Patent: 7,132,112, 2006; November 7.