Mycelia extracts of fungal strains isolated from Cordyceps sinensis differently enhance the function of RAW 264.7 macrophages

Journal of Ethnopharmacology

Volumn 148, Issue 3, 2013, Pages 818-825

  Meng, Lan Zhen ^a   Lin, Bao Qin ^a,b   Wang, Bo ^a,c   Feng, Kun ^a   Hu, De Jun ^a   Wang, Lan Ying ^a   Cheong, Kit Leong ^a   Zhao, Jing ^a   Li, Shao Ping ^a  

^a University of Macau   (Macao)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^c PAREXEL INTERNATIONAL   (United States)

Author keywords

Cordyceps sinensis; Cultured Cordyceps; Immuno potentiation activity; RAW 264.7 macrophages

Indexed keywords

CORDYCEPS SINENSIS EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; NITRIC OXIDE; POLYSACCHARIDE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FUNGAL STRAIN; FUNGUS CULTURE; FUNGUS ISOLATION; GENE TRANSLOCATION; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; IN VITRO STUDY; MACROPHAGE; MACROPHAGE FUNCTION; MOUSE; MYCELIUM; NONHUMAN; OPHIOCORDYCEPS; PHAGOCYTOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

3-(4, 5-DIMETHYLTHAZOL-2-YL)-2, 5-DIPHENYL TETRAZOLIUM BROMIDE; AE; AQUEOUS EXTRACT; CORDYCEPS SINENSIS; CP; CRUDE POLYSACCHARIDES; CULTURED CORDYCEPS; DMEM; DULBECCO'S MODIFIED EAGLE MEDIUM; FBS; FETAL BOVINE SERUM; IL; IMMUNO-POTENTIATION ACTIVITY; INTERLEUKIN; LIPOPOLYSACCHARIDE; LPS; MTT; NITRIC OXIDE; NO; PBS; PHOSPHATE-BUFFERED SALINE; RAW 264.7 MACROPHAGES; SM; SMALL MOLECULAR COMPOUNDS; TNF-Α; TUMOR NECROSIS FACTOR-Α;

ANIMALS; BIOLOGICAL PRODUCTS; CELL LINE; CELL PROLIFERATION; CORDYCEPS; CYTOKINES; MACROPHAGES; MICE; MYCELIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHAGOCYTOSIS;

CORDYCEPS; CORDYCEPS SINENSIS; FUNGI;

EID: 84880287956     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.05.017     Document Type: Article

References (28)

1. J.K.H. Cheung, J. Li, A.W.H. Cheung, Y. Zhu, K.Y.Z. Zheng, C.W.C. Bi, R. Duan, R.C.Y. Choi, D.T.W. Lau, T.T.X. Dong, B.W.C. Lau, and K.W.K. Tsim Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines Journal of Ethnopharmacology 124 2009 61 68
2. F. Denizot, and R. Lang Rapid colorimetric assay for cell growth and survivalmodifications to the tetrazolium dye procedure giving improved sensitivity and reliability Journal of Immunological Methods 89 1986 271 277
3. K. Feng, S. Wang, D.J. Hu, F.Q. Yang, H.X. Wang, and S.P. Li Random amplified polymorphic DNA (RAPD) analysis and the nucleosides assessment of fungal strains isolated from natural Cordyceps sinensis Journal of Pharmaceutical and Biomedical Analysis 50 2009 522 526
4. R.S. Flannagan, V. Jaumouillé, and S. Grinstein The cell biology of phagocytosis Annual Review of Pathology 7 2012 61 98
5. S. Gallagher, S.E. Winston, S.A. Fuller, and J.G.R. Hurrell Immunoblotting and immunodetection Current Protocols in Cell Biology 52 2 2011 6.2.1 6.2.28
6. J. Guan, F.Q. Yang, and S.P. Li Evaluation of carbohydrates in natural and cultured Cordyceps by pressurized liquid extraction and gas chromatography coupled with mass spectrometry Molecules 15 2010 4227 4241
7. J. Guan, J. Zhao, K. Feng, D.J. Hu, and S.P. Li Comparison and characterization of polysaccharides from natural and cultured Cordyceps using saccharide mapping Analytical and Bioanalytical Chemistry 399 2011 3465 3474
8. N.B. Hao, M.H. Lü, Y.H. Fan, Y.L. Cao, Z.R. Zhang, and S.M. Yang Macrophages in tumor microenvironments and the progression of tumors Clinical and Developmental Immunology 2012 10.1155/2012/948098
9. Ka Wai Lee S., Kwok Wong C., Kai Kong S., Nam Leung K., and Wai Kei Lam C. Immunomodulatory activities of HERBSnSENSES™ Cordyceps - in vitro and in vivo studies Immunopharmacology and Immunotoxicology 28 2006 341 360
10. H. Kleinert, A. Pautz, K. Linker, and P.M. Schwarz Regulation of the expression of inducible nitric oxide synthase European Journal of Pharmacology 500 2004 255 266
11. S.P. Li, Z.R. Su, T.T.X. Dong, and K.W.K. Tsim The fruiting body and its caterpillar host of Cordyceps sinensis show close resemblance in main constituents and anti-oxidation activity Phytomedicine 9 2002 319 324
12. S.P. Li, F.Q. Yang, and K.W.K. Tsim Quality control of Cordyceps sinensis, a valued traditional Chinese medicine Journal of Pharmaceutical and Biomedical Analysis 41 2006 1571 1584
13. X.T. Li, H.C. Li, C.B. Li, D.Q. Dou, and M.B. Gao Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris American Journal of Chinese Medicine 38 2010 1093 1106
14. Z.Y. Liu, Z.Q. Liang, A.Y. Liu, Y.J. Yao, K.D. Hyde, and Z.N. Yu Molecular evidence for teleomorph-anamorph connections in Cordyceps based on its - 5.8S rDNA sequences Mycological Research 106 2002 1100 1108
15. Z.Y. Liu, Y.J. Yao, L. Zang Qi, A.Y. Liu, D.N. Pegler, and M.W. Chase Molecular evidence for the anamorph-teleomorph connection in Cordyceps sinensis Mycological Research 105 2001 827 832
16. H.C. Lo, C. Hsieh, F.Y. Lin, and T.H. Hsu A systematic review of the mysterious caterpillar fungus Ophiocordyceps sinensis in DongChongXiaCao and related bioactive ingredients Journal of Traditional and Complementary Medicine 3 2013 16 32
17. K.M. Miranda, M.G. Espey, and D.A. Wink A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite Nitric Oxide - Biology and Chemistry 5 2001 62 71
18. R.R.M. Paterson Cordyceps - a traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry 69 2008 1469 1495
19. Pharmacopoeia Commission of PRC, 2010. Pharmacopoeia of the People's Repubilc of China (Ed.), Chemical Industry Publishing, Beijing, pp. 106.
20. A. Salminen, J. Huuskonen, J. Ojala, A. Kauppinen, K. Kaarniranta, and T. Suuronen Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging Ageing Research Reviews 7 2008 83 105
21. T. Sládková, and F. Kostolanský The role of cytokines in the immune response to influenza A virus infection Acta Virologica 50 2006 151 162
22. G.H. Sung, N.L. Hywel-Jones, J.M. Sung, J.J. Luangsa-ard, B. Shrestha, and J.W. Spatafora Phylogenetic classification of Cordyceps and the clavicipitaceous fungi Studies in Mycology 57 2007 5 59
23. M. Wang, X.Y. Meng, R.L. Yang, T. Qin, X.Y. Wang, K.Y. Zhang, C.Z. Fei, Y. Li, Y.L. Hu, and F.Q. Xue Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice Carbohydrate Polymers 89 2012 461 466
24. S.Y. Wang, and M.S. Shiao Pharmacological functions of Chinese medicinal fungus Cordyceps sinensis and related species Journal of Food and Drug Analysis 8 2000 248 257
25. Z.M. Wang, X. Peng, K.L.D. Lee, J.C.O. Tang, P.C.K. Cheung, and J.Y. Wu Structural characterisation and immunomodulatory property of an acidic polysaccharide from mycelial culture of Cordyceps sinensis fungus Cs-HK1 Food Chemistry 125 2011 637 643
26. 60Co International Immunopharmacology 11 2011 2251 2257
27. Y. Zhang, S. Zhang, M. Wang, F. Bai, and X. Liu High diversity of the fungal community structure in naturally-occurring Ophiocordyceps sinensis PLoS ONE 5 2010 e15570
28. Z.Y. Zhu, N. Liu, C.L. Si, Y. Liu, L.N. Ding, C. Jing, A.J. Liu, and Y.M. Zhang Structure and anti-tumor activity of a high-molecular-weight polysaccharide from cultured mycelium of Cordyceps gunnii Carbohydrate Polymers 88 2012 1072 1076