HEMA/MMMA microcapsule implants in hemiparkinsonian rat brain: Biocompatibility assessment using [3H]PK11195 as a marker for gliosis

Biomaterials

Volumn 19, Issue 7-9, 1998, Pages 829-837

  Campioni, Elly G ^a   Nobrega, José N ^a,b   Sefton, Michael V ^c  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

3H PK11195; Autoradiography; Biocompatibility; Dopamine; Gliosis; Parkinson's disease; PC12 cells; Polymer encapsulation; Striatum

Indexed keywords

AMINES; BIOCOMPATIBILITY; BIOMARKERS; BRAIN; CELLS; COPOLYMERS; ENCAPSULATION; OPTICAL MICROSCOPY; POLYMERIC MEMBRANES; POLYMETHYL METHACRYLATES; RADIOGRAPHY;

AUTORADIOGRAPHY; DOPAMINE; POLYHYDROXYETHYL METHACRYLATE;

IMPLANTS (SURGICAL);

DOPAMINE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; POLYMACON; TRITIUM;

ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; BIOCOMPATIBILITY; CELL STRAIN; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; IMPLANT; INFLAMMATION; MALE; MICROCAPSULE; MICROENCAPSULATION; MICROSCOPY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

ANIMALS; AUTORADIOGRAPHY; BIOCOMPATIBLE MATERIALS; BRAIN; CAPSULES; COCAINE; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; GLIOSIS; ISOQUINOLINES; MALE; METHYLMETHACRYLATES; PARKINSON DISEASE, SECONDARY; PC12 CELLS; POLYHYDROXYETHYL METHACRYLATE; PROSTHESES AND IMPLANTS; RATS; RATS, SPRAGUE-DAWLEY; TRITIUM;

EID: 0032053061     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(97)00241-X     Document Type: Article

References (27)

1. [1] Monahan J. Past progress and current trends in cell transplantation. J Cellular Biochem 1991;45:317-18.
2. [2] Olanov CW, Kosdower JH, Freeman TB. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends in Neurosci 1996;19:102-9.
3. [3] Winn SR, Wahlberg PA, Tresco PA, Aebischer P. An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats. Exp Neurol 1989;105:244-50.
4. [4] Aebischer P, Winn SR, Tresco PA, Jaeger CB, Greene LA. Transplantation of polymer encapsulated neurotransmitter secreting cells: effect of the encapsulation technique. J Biomech Engng 1991;113:178-83.
5. [5] Kordower JH, Liu Y-T, Winn S, Emerich DF. Encapsulated PC12 cell transplants into hemiparkinsonian monkeys: a behavioural, neuroanatomical and neurochemical analysis. Cell Transplant 1995;4:155-71.
6. [6] Greene LA, Sobeih MM, Tang KK. Methodologies for the culture and experimental use of the PC12 rat pheochromocytoma cell line. In: Barker G, Goslin K, editors. Culturing nerve cells. Cambridge Mass: MIT Press, 1991:207-26.
7. [7] Greene LA, Tischler AS. PC12 Pheochromocytoma cultures in neurobiological research. Adv Cellular Neurobiol 1982;3:373-414.
8. [8] Aebischer P, Goddard M, Signore AP, Timpson RL. Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells. Exp Neurol 1994;126:151-58.
9. [9] Date I, Miyoshi Y, Ono T, Imaoka T, Furuta T, Asari S, Ohmoto T, Iwata H. Preliminary report of polymer encapsulated dopamine secreting cell grafting into the brain. Cell Transpl 1996;5:S17-19.
10. [10] Gin H, Dupuy B, Bonnemaison-Boourignon D, Bordenave L, Bareille R, Latepie MJ, Baquey Ch, Bezian JH, Ducassou D. Biocompatibililty of polyacrylamide microcapsules implanted in peritoneal cavity or spleen of the rat: effects of various inflammatory reactions in vitro. Biomat Artif Cells Artif Org 1990;18:25.
11. [11] Miller KM, Anderson JM. Human monocyte/macrophage activation and interleukin 1 generation by biomedical polymers. J Biomed Mater Res 1988;22:713.
12. [12] Babensee JE, Sefton MV. Protein delivery by microencapsulated cells. In: Park K, editor. Controlled drug delivery. American Chemical Society, Washington DC, 1997;311-32.
13. [13] Roberts TF, De Boni U, Sefton MV. Dopamine secretion by PC12 cells microencapsulated in a hydroxyethyl methacrylate-methyl methacrylate copolymer. Biomaterials 1996; 17:267-75.
14. [14] Benavides J, Fage D, Carter C, Scatton B. Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage. Brain Res 1987;421:167-72.
15. 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration. Brain Res 1990;522:275-89.
16. 3H]PK 11195 binding autoradiography. Exp Neurol 1990;109:333-41.
17. 3H]PK 11195. Brain Res Bull 1989;13:69-77.
18. [18] Uludag H, Horvath V, Black JP, Sefton MV. Viability and protein secretion for human hepatoma (HepG2) cells encapsulated in 400 μm polyacrylate microcapsules by submerged nozzle - liquid jet extrusion. Biotech Bioengng 1994;44:1199.
19. 3H]PK 11195 in rat brain following portacaval anastomosis. Brain Res 1992;585:295-98.
20. [20] Wilson JW, Nobrega JN, Carroll ME, Niznik HB, Shannak K, Lac ST, Pristupa ZB, Dixon LM, Kish SJ. Heterogenous subregional binding patterns of 3H-WIN 35428 and 3H-GBR 12935 are differentially regulated by chronic cocaine self-administration. J Neurosci 1994;14:2966-79.
21. 3H]PK 11195: anatomical and subcellular distribution. Brain Res Bull 1987;18: 49-61.
22. 3H]PK 11195: an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization. J Neurochem 1983;41:1744-50.
23. 3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion. J Cerebral Blood Flow Metabolism 1991;11: 314-22.
24. [24] During MJ, Freese A, Sabel BA, Saltzman WM, Deutch A, Roth RH, Langer R. Controlled release of dopamine from a polymeric brain implant: in vivo characterization. Ann Neurol 1989;25: 351-55.
25. [25] Winn SR, Aebischer P, Galletti PM. Brain tissue reaction to permselective polymer capsules. J Biomed Mater Res 1989;23:31-44.
26. [26] Rubin E, Farber JL (Eds.). Pathology. Philadelphia: J.B. Lippincott Co., 1988:34-64.
27. [27] Babensee JE, Sefton MV. Transplantation of human and rat hepatoma cell lines into rats within small diameter HEMA-MMA microcapsules (in preparation).