Cross-reactivities and structure-reactivity relationships of six benzodiazepines to EMIT® immunoassay

Journal of Pharmaceutical and Biomedical Analysis

Volumn 84, Issue , 2013, Pages 168-172

  Bertol, Elisabetta ^a   Vaiano, Fabio ^a   Furlanetto, Sandra ^a   Mari, Francesco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Benzodiazepines; Cross reactivity; EMIT; Immunoassay; LC MS MS

Indexed keywords

3 HYDROXYFLUNITRAZEPAM; 7 AMINO 1,3 DIHYDRO 5 PHENYL 2H 1,4 BENZODIAZEPIN 2 ONE; ALPHA HYDROXY MIDAZOLAM; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BROTIZOLAM; DELORAZEPAM; HALAZEPAM; PINAZEPAM; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CROSS REACTION; DRUG MANUFACTURE; DRUG METABOLISM; DRUG SCREENING; ENZYME MULTIPLIED IMMUNOASSAY TECHNIQUE; IMMUNOLOGY TEST KIT; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; MOLECULE; PREDICTIVE VALUE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY; URINE;

BENZODIAZEPINES; CROSS-REACTIVITY; EMIT; IMMUNOASSAY; LC-MS/MS;

BENZODIAZEPINES; CHROMATOGRAPHY, LIQUID; CROSS REACTIONS; FORENSIC TOXICOLOGY; IMMUNOASSAY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84880268033     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.05.026     Document Type: Article

References (12)

1. Schwartz R.H., Milteer R., LeBeau M.A. Drug-facilitated sexual assault. South Med. J. 2000, 93:558-561.
2. Rickert V.I., Wiemann C.M., Berenson A.B. Flunitrazepam: more than a date rape drug. J. Pediatr. Adolesc. Gynecol. 2000, 13:7-42.
3. Scott-Ham M., Burton F.C. Toxicological findings in cases of alleged drug-facilitated sexual assault in the United Kingdom over a 3-year period. J. Clin. Forensic Med. 2005, 12:175-186.
4. ElSohly M.A., Gul W., Murphy T.P., Avula B., Khan I.A. LC-(TOF) MS analysis of benzodiazepines in urine from alleged victims of drug-facilitated sexual assault. J. Anal. Toxicol. 2007, 31:505-514.
5. Steward S.H., Westra H.A. Benzodiazepine side-effects: from the bench to the clinic. Curr. Pharm. Des. 2002, 8:1-3.
6. Mandrioli R., Mercolini L., Raggi M.A. Benzodiazepine metabolism: an analytical perspective. Curr. Drug. Metab. 2008, 9:827-844.
7. Bertol E., Mari F., Torracca F. Comparison of lidocaine by fluorescence polarization immunoassay, enzyme immunoassay, and high resolution gas chromatography. J. Anal. Toxicol. 1987, 11:122-124.
8. Spiehler V. Hair analysis by immunological methods from the beginning to 2000. Forensic Sci. Int. 2000, 107:249-259.
9. ® assays for use in drugs enforcement. Forensic Sci. Int. 2012, 217:174-181.
10. Ruprich J., Ostry V. Immunochemical methods in health risk assessment: cross reactivity of antibodies against mycotoxin deoxynivalenol with deoxynivalenol-3-glucoside. Cent. Eur. J. Public Health 2008, 16:34-37.
11. Flanagan R.J., Taylor A., Watson I.D., Whelpton R. Fundamentals of Analytical Toxicology 2007, John Wiley & Sons, West Sussex, UK.
12. Hand C., Baldwin D. Immunoassay. Clark's Analytical Forensic Toxicology 2008, 375-391. Pharmaceutical Press, London, UK. S. Jickells, A. Negrusz (Eds.).