LC-(TOF) MS analysis of benzodiazepines in urine from alleged victims of drug-facilitated sexual assault

Journal of Analytical Toxicology

Volumn 31, Issue 8, 2007, Pages 505-514

  ElSohly, Mahmoud A ^a,b,c   Gul, Waseem ^a,b   Murphy, Timothy P ^a   Avula, Bharathi ^b   Khan, Ikhlas A ^b,c  

^a ElSohly Laboratories Incorporated   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; CLONAZEPAM; DIAZEPAM; FLUDIAZEPAM; FLUNITRAZEPAM; FLURAZEPAM; LORAZEPAM; LORMETAZEPAM; MIDAZOLAM; NITRAZEPAM; NORDAZEPAM; OXAZEPAM; TEMAZEPAM; TRIAZOLAM;

ARTICLE; DRUG URINE LEVEL; HUMAN; IMMUNOASSAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SEXUAL CRIME; URINALYSIS;

EID: 36448990101     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/31.8.505     Document Type: Article

References (13)

1. S. Cohen. The benzodiazepines. Psychiatr. Ann. 13: 65-70 (1983).
2. United Nations International Drug Control Programme. Recommended methods for the detection and assay of barbiturates and benzodiazepines in biological specimens. United Nations International Drug Control Programme Publication ST/NAR/28. Vienna, Austria, 1997.
3. D. Anglin, K.L. Spears, and H.R. Hutson. Flunitrazepam and its involvement in date or acquaintance rape. Acad. Emer. Med. 4: 323-326 (1997).
4. J.H. Woods and G. Winger. Abuse liability of flunitrazepam. J. Clin. Psychopharmacol. 17: 1-57 (1997).
5. M.A. ElSohly, S. Feng, S.J. Salamone, and R. Wu. A sensitive GC-MS procedure for the analysis of flunitrazepam and its metabolites in urine. J. Anal. Toxicol. 21: 335-340 (1997).
6. M.A. ElSohly, L.F. Lee, L.B. Holzhauer, and S.J. Salamone. Analysis of urine samples in cases of alleged sexual assault: case history. In Forensic Science: Benzodiazepines and GHB: Detection and Pharmacology, S.J. Salamone, Ed. Humana Press, Totowa, NJ, 1997, pp 127-144.
7. M.A. ElSohly, W. Gul, K.M. ElSohly, B. Avula, and I.A. Khan. LC-MS (TOF) analysis method for benzodiazepines in urine samples from alleged drug-facilitated sexual assault victims. J. Anal. Toxicol. 30: 1-15 (2006).
8. M.J. Ellenhorn and D.G. Barceloux. Medical Toxicology, Diagnosis, and Treatment of Human Poisoning. Elsevier, New York, NY, 1988, pp 580-596.
9. IMS Health, 2006.
10. H. Huan, Z. Mester, H. Lord, and J. Pawliszyn. Automated intube, solid-phase microextraction coupled with liquid chromatography-electrospray ionization mass spectrometry for the determination of selected benzodiazepines. J. Anal. Toxicol. 24: 718-725 (2000).
11. A. Miki, M. Tatsuno, M. Katagi, M. Nishikawa, and H. Tsuchihasi. Simultaneous determination of eleven benzodiazepine hypnotics and eleven relevant metabolites in urine by column-switching liquid chromatography-mass spectrometry. J. Anal. Toxicol. 26: 87-93 (2002).
12. S. Schlueter, J. Hutchison, J.M. Hughes and M. Zumwalt. Identification and Quantification of Benzodiazepines and Metabolites by LC/MS. Agilent Technologies, www.agilent.com/chem. 5989-4639EN, 2006.
13. H. Rivera, G.S. Walker, P. Stockham, D.N. Sims, and J.M. Hughes. Analysis of Benzodiazepines in Blood by LC/MS/MS. Agilent Technologies, www.agilent.com/chem. 5989-4737EN, 2006.