Chronotropic incompetence predicts impaired response to exercise training in heart failure patients with sinus rhythm

European Journal of Preventive Cardiology

Volumn 20, Issue 4, 2013, Pages 585-592

  Schmid, Jean Paul ^a   Zurek, Marzena ^a   Saner, Hugo ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Chronotropic incompetence; exercise training; heart failure; heart rate

Indexed keywords

ADULT; ARTICLE; BICYCLE ERGOMETER; CARDIOPULMONARY EXERCISE TEST; CONGENITAL HEART DISEASE; ENDURANCE TRAINING; EXERCISE; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART RATE; HEART REHABILITATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SINUS RHYTHM; TREATMENT DURATION; WORKLOAD;

CHRONOTROPIC INCOMPETENCE; EXERCISE TRAINING; HEART FAILURE; HEART RATE;

AGED; AMBULATORY CARE; CHI-SQUARE DISTRIBUTION; EXERCISE TEST; EXERCISE THERAPY; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEART RATE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OXYGEN CONSUMPTION; RECOVERY OF FUNCTION; ROC CURVE; STROKE VOLUME; TIME FACTORS; TREATMENT OUTCOME;

EID: 84880266731     PISSN: 20474873     EISSN: None     Source Type: Journal    
DOI: 10.1177/2047487312444368     Document Type: Article

References (29)

1. Coats AJ. The 'muscle hypothesis' of chronic heart failure. J Mol Cell Cardiol. 1996 ; 28: 2255-2262
2. Protocol and patient factors in effectiveness in the improvement in exercise tolerance. European Heart Failure Training Group. Eur Heart J. 1998 ; 19: 466-475
3. Tabet JY, Meurin P, Beauvais F, et al. Absence of exercise capacity improvement after exercise training program: a strong prognostic factor in patients with chronic heart failure. Circ Heart Fail. 2008 ; 1: 220-226
4. Higginbotham MB, Morris KG, Conn EH, et al. Determinants of variable exercise performance among patients with severe left ventricular dysfunction. Am J Cardiol. 1983 ; 51: 52-60
5. Meyer K, Gornandt L, Schwaibold M, et al. Predictors of response to exercise training in severe chronic congestive heart failure. Am J Cardiol. 1997 ; 80: 56-60
6. Kemps HM, Schep G, de Vries WR, et al. Predicting effects of exercise training in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2008 ; 102: 1073-1078
7. Wilson JR, Groves J, Rayos G. Circulatory status and response to cardiac rehabilitation in patients with heart failure. Circulation. 1996 ; 94: 1567-1572
8. Sullivan MJ, Knight JD, Higginbotham MB, et al. Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure. Circulation. 1989 ; 80: 769-781
9. Binder RK, Wonisch M, Corra U, et al. Methodological approach to the first and second lactate threshold in incremental cardiopulmonary exercise testing. Eur J Cardiovasc Prev Rehabil. 2008 ; 15: 726-734
10. Katritsis D, Camm AJ. Chronotropic incompetence: a proposal for definition and diagnosis. Br Heart J. 1993 ; 70: 400-402
11. Witte KK, Cleland JG, Clark AL. Chronic heart failure, chronotropic incompetence, and the effects of beta blockade. Heart. 2006 ; 92: 481-486
12. Jorde UP, Vittorio TJ, Kasper ME, et al. Chronotropic incompetence, beta-blockers, and functional capacity in advanced congestive heart failure: time to pace?. Eur J Heart Fail. 2008 ; 10: 96-101
13. Clark AL, Coats AJ. Chronotropic incompetence in chronic heart failure. Int J Cardiol. 1995 ; 49: 225-231
14. Witte KK, Clark AL. Chronotropic incompetence does not contribute to submaximal exercise limitation in patients with chronic heart failure. Int J Cardiol. 2009 ; 134: 342-344
15. Clark AL, Poole-Wilson PA, Coats AJ. Exercise limitation in chronic heart failure: central role of the periphery. J Am Coll Cardiol. 1996 ; 28: 1092-1102
16. Warburton DE, Haykowsky MJ, Quinney HA, et al. Myocardial response to incremental exercise in endurance-trained athletes: influence of heart rate, contractility and the Frank-Starling effect. Exp Physiol. 2002 ; 87: 613-622
17. Colucci WS, Ribeiro JP, Rocco MB, et al. Impaired chronotropic response to exercise in patients with congestive heart failure. Role of postsynaptic beta-adrenergic desensitization. Circulation. 1989 ; 80: 314-323
18. White M, Yanowitz F, Gilbert EM, et al. Role of beta-adrenergic receptor downregulation in the peak exercise response in patients with heart failure due to idiopathic dilated cardiomyopathy. Am J Cardiol. 1995 ; 76: 1271-1276
19. Sanders P, Kistler PM, Morton JB, et al. Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve. Circulation. 2004 ; 110: 897-903
20. Freeman JV, Dewey FE, Hadley DM, et al. Autonomic nervous system interaction with the cardiovascular system during exercise. Prog Cardiovasc Dis. 2006 ; 48: 342-362
21. Roche F, Pichot V, Da Costa A, et al. Chronotropic incompetence response to exercise in congestive heart failure, relationship with the cardiac autonomic status. Clin Physiol. 2001 ; 21: 335-342
22. Fei L, Keeling PJ, Sadoul N, et al. Decreased heart rate variability in patients with congestive heart failure and chronotropic incompetence. Pacing Clin Electrophysiol. 1996 ; 19: 477-483
23. Malfatto G, Branzi G, Riva B, et al. Recovery of cardiac autonomic responsiveness with low-intensity physical training in patients with chronic heart failure. Eur J Heart Fail. 2002 ; 4: 159-166
24. Myers J, Hadley D, Oswald U, et al. Effects of exercise training on heart rate recovery in patients with chronic heart failure. Am Heart J. 2007 ; 153: 1056-1063
25. Sullivan MJ, Hawthorne MH. Exercise intolerance in patients with chronic heart failure. Prog Cardiovasc Dis. 1995 ; 38: 1-22
26. Roubin GS, Anderson SD, Shen WF, et al. Hemodynamic and metabolic basis of impaired exercise tolerance in patients with severe left ventricular dysfunction. J Am Coll Cardiol. 1990 ; 15: 986-994
27. Magnusson G, Kaijser L, Sylven C, et al. Peak skeletal muscle perfusion is maintained in patients with chronic heart failure when only a small muscle mass is exercised. Cardiovasc Res. 1997 ; 33: 297-306
28. Alpert MA, Curtis JJ, Sanfelippo JF, et al. Comparative survival after permanent ventricular and dual chamber pacing for patients with chronic high degree atrioventricular block with and without preexistent congestive heart failure. J Am Coll Cardiol. 1986 ; 7: 925-932
29. Steinberg JS, Fischer A, Wang P, et al. The clinical implications of cumulative right ventricular pacing in the multicenter automatic defibrillator trial II. J Cardiovasc Electrophysiol. 2005 ; 16: 359-365