Androgen therapy in women, beyond libido

Climacteric

Volumn 16, Issue S1, 2013, Pages 18-24

  Davis, S R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Androgen therapy; Libido

Indexed keywords

ANDROGEN; ANDROSTANOLONE; PLACEBO; TESTOSTERONE;

AGING; ANDROGEN THERAPY; AROUSAL; ARTICLE; BODY COMPOSITION; CARDIOVASCULAR FUNCTION; CELL PROLIFERATION; CLINICAL PRACTICE; COGNITION; FERTILIZATION IN VITRO; HUMAN; LIBIDO; METABOLIC SYNDROME X; MUSCULOSKELETAL SYSTEM; ORGASM; OVARY FOLLICLE; POSTMENOPAUSE; PREMENOPAUSE; PRESCRIPTION; PRIORITY JOURNAL; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SEXUAL SATISFACTION; SEXUALITY; VAGINA; WOMEN'S HEALTH;

BODY COMPOSITION; BONE DENSITY; BREAST NEOPLASMS; CARDIOVASCULAR SYSTEM; COGNITION; FEMALE; FERTILIZATION IN VITRO; HUMANS; LIBIDO; MENOPAUSE; ORGASM; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; TESTOSTERONE;

EID: 84880264337     PISSN: 13697137     EISSN: 14730804     Source Type: Journal    
DOI: 10.3109/13697137.2013.801736     Document Type: Article

References (79)

1. Davis S R, Panjari M, Stanczyk FZ. DHEA replacement for postmenopausal women. J Clin Endocrinol Metab 2011 ; 96 : 1642-53
2. Panjari M, Davis SR. Vaginal DHEA to treat menopause related atrophy: A review of the evidence. Maturitas 2011 ; 70 : 22-5
3. David K, Dingemanse E, Freud J, Laqueur E. U ber krystallinisches mannliches Hormon aus Hoden (Testosteron) wirksamer als aus harn oder aus Cholesterin bereitetes Androsteron. Hoppe Seylers Z Physiol Chem 1935; 233 : 281
4. Butenandt A, Hanisch G. Uber Testosterone. Umwandlung des Dehydro-Androsterons in Androstendiol und Testosteron; ein Weg zur Darstellung des Testosterons aus Cholestrin. Hoppe Seylers Z Physiol Chem 1935; 237 : 89
5. Engstrom WW, Munson PL. Studies on the metabolism of testosterone in normal women in different phases of the menstrual cycle. J Clin Endocrinol Metab 1951 ; 11 : 427-33
6. Hallberg O, Nohrman B, Sylven B. S urvival time in women with disseminated breast cancer, following testosterone treatment. Acta Radiol 1953 ; 39 : 161-8
7. Davis MB. The use of testosterone in women with recurrent breast cancer. J Tennessee State Med Assoc 1948 ; 41 : 213-18
8. Moehlig R C, Gerisch R A. M ethyl testosterone for migraine of women. J Michigan State Med Soc 1949 ; 48 : 1025-8
9. Burdine WE, Shipley T E, Papas AT. Delatestryl, along-Acting androgenic hormone; its use as an adjunct in the treatment of women with sexual frigidity. Fertil Steril 1957 ; 8 : 255-9
10. Greenblatt RB. T he use of androgens in the menopause and other gynecic disorders. Obstet Gynecol Clin North Am 1987 ; 14 : 251-68 (Pubitemid 18061596)
11. Simpson ER, Davis SR. Minireview: Aromatase and the regulation of estrogen biosynthesis-some new perspectives. Endocrinology 2001 ; 142 : 4589-94 (Pubitemid 33022332)
12. Dunn J F, Nisula B C, Rodboard D. T ransport of steroid hormones. Binding of 21 endogenous steroids to both testosterone-binding globulin and cortico-steroid-binding globulin in human plasma. J Clin Endocrinol Metab 1981 ;53: 58-68 (Pubitemid 13245381)
13. Zumoff B, Strain G W, Miller L K, Rosner W. T wenty-four hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab 1995 ; 80 : 1429-30
14. Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: Changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005 ; 90 : 3847-53 (Pubitemid 41058142)
15. Vendola KA, Zhou J, Adesanya OO, Weil SJ, Bondy CA. Androgens stimulate early stages of follicular growth in the primate ovary. J Clin Invest 1998 ; 101 : 2622-9 (Pubitemid 28294570)
16. Bosdou JK, Venetis CA, Kolibianakis EM, et al. The use of androgens or androgen-modulating agents in poor responders undergoing in vitro fertilization: A systematic review and metaanalysis. Hum Reprod Update 2012 ; 18 : 127-45
17. Goldstat R, Briganti E, Tran J, Wolfe R, Davis S. T ransdermal testosterone improves mood, well being and sexual function in premenopausal women. Menopause 2003 ; 10 : 390-8
18. Davis S R, Papalia M A, Norman R J, et a l. S afety and Efficacy of a testosterone metered-dose transdermal spray for treatment of decreased sexual satisfaction in premenopausal women: A placebo-controlled randomized, dose-ranging study. Ann Intern Med 2008 ; 148 : 569-77 (Pubitemid 351669130)
19. Shifren J L, Braunstein G, Simon J, et a l. T ransdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000 ; 343 : 682-8
20. Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005 ; 90 : 5226-33 (Pubitemid 41262278)
21. Braunstein G, Shifren J, Simon J, Lucas J, Rodenberg C, Watts NB. Testosterone patches for the treatment of low sexual desire in surgically menopausal women. Proceedings of the 14th Annual Meeting of the North American Menopause Society, 2003
22. Davis SR, van der Mooren MJ, van Lunsen RHW, et al. The Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: A randomized, placebo-controlled trial. Menopause 2006 ; 13 : 387-96
23. Shifren J, Davis SR, Moreau M, et al. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: Results from the INTIMATE NM1 study. Menopause 2006 ; 13 : 770-9
24. Panay N, Al-Azzawi F, Bouchard C, et al. Testosterone treatment of HSDD in naturally menopausal women: The ADORE study. Climacteric 2010 ; 13 : 121-31
25. Davis S R, Moreau M, Kroll R, et a l. T estosterone for low libido in menopausal women not taking estrogen therapy. N Engl J Med 2008 ; 359 : 2005-17
26. Baldassarre M, Perrone AM, Giannone FA, et al. Androgen receptor expression in the human vagina under different physiological and treatment conditions. Int J Impot Res 2013 ; 25 : 7-11
27. Leiblum S, Bachmann GA, Kemmann E, Colburn D, Schwartzman L. The importance of sexual activity and hormones. JAMA 1983; 249 : 2195
28. Witherby S, Johnson J, Demers L, et a l. Topical testosterone for breast cancer patients with vaginal atrophy related to aromatase inhibitors: A phase I/II study. Oncologist 2011 ; 16 : 424-31
29. Dubois V, Laurent M, Boonen S, Vanderschueren D, Claessens F. Androgens and skeletal muscle: Cellular and molecular action mechanisms underlying the anabolic actions. Cell Molec Life Sci 2012 ; 69 : 1651-67
30. Davis S R, Walker K Z, Strauss B J. Effects of estradiol with and without testosterone on body composition and relationships with lipids in post-menopausal women. Menopause 2000 ; 7 : 395-401
31. Dobs AS, Nguyen T, Pace C, Roberts C. Differential effects of oral estrogen versus estrogen-Androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab 2002 ; 87 : 1509-16 (Pubitemid 34615230)
32. Miller K K, Biller B M, Beauregard C, et a l. Effects of testosterone replacement in androgen-defi cient women with hypopituitarism: A randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2006 ; 91 : 1683-90
33. Miller KK, Lawson EA, Mathur V, et al. Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea. J Clin Endocrinol Metab 2007 ; 92 : 1334-9 (Pubitemid 46556406)
34. Lawson EA, Miller KK, Bredella MA, et al. Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa. Bone 2010 ; 46 : 458-63
35. Dalton J T, Barnette K G, Bohl C E, et a l. T he selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: Results of a double-blind, placebocontrolled phase II trial. J Cachexia, Sarcopenia and Muscle 2011 ; 2 : 153-61
36. Kasperk CH, Wergedal JE, Farley JR, Llinkhart TA, Turner RT, Baylink DG. Androgens directly stimulate proliferation of bone cells in vitro. Endocrinology 1989 ; 124 : 1576-8 (Pubitemid 19082736)
37. Slemenda C, Longcope C, Peacock M, Hui S, Johnston C C. Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-And postmenopausal women. J Clin Invest 1996 ; 97 : 14-21
38. Lee JS, LaCroix AZ, Wu L, et al. Associations of serum sex hormone-binding globulin and sex hormone concentrations with hip fracture risk in postmenopausal women. J Clin Endocrinol Metab 2008 ; 93 : 1796-803 (Pubitemid 351656520)
39. Davis S R, McCloud P I, Strauss B JG, Burger H G. T estosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995 ; 21 : 227-36
40. Watts NB, Notelovitz M, Timmons MC, Addison WA, Wiita B, Downey LJ. Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms and lipid-lipoprotein profi les in surgical menopause. Obstet Gynecol 1995 ; 85 : 529-37
41. Davis SR. Cardiovascular and cancer safety of testosterone in women. Curr Opin Endocrinol Diabetes Obes 2011 ; 18 : 198-203
42. Montalcini T, Gorgone G, Gazzaruso C, Sesti G, Perticone F, Pujia A. Endogenous testosterone and endothelial function in postmenopausal women. Coron Artery Dis 2007 ; 18 : 9-13 (Pubitemid 44973750)
43. Bernini G, Sgro M, Moretti A. E ndogenous androgens and carotid intimal-medial thickness in women. J Clin Endocrinol Metab 1999; 84 : 2008
44. Debing E, Peeters E, Duquet W, Poppe K, Velkeniers B, Van den Brande P. Endogenous sex hormone levels in postmenopausal women undergoing carotid artery endarterectomy. Eur J Endocrinol 2007 ; 156 : 687-93 (Pubitemid 46952539)
45. Naessen T, Sjogren U, Bergquist J, Larsson M, Lind L, Kushnir MM. Endogenous steroids measured by high-specifi city liquid chromatography-Tandem mass spectrometry and prevalent cardiovascular disease in 70-year-old men and women. J Clin Endocrinol Metab 2010 ; 95 : 1889-97
46. Wild S, Pierpoint T, Jacobs H, McKeigue P. L ong-Term consequences of polycystic ovary syndrome: Results of a 31 year follow-up study. Hum Fertil 2000 ; 3 : 101-5
47. Chou TM, Sudhir K, Hutchison SJ, et al. Testosterone induces dilation of canine coronary conductance and resitstance arteries in vivo. Circulation 1996; 94 : 2614
48. Davison S, Thipphawong J, Blanchard J, et a l. P harmacokinetics and acute safety of inhaled testosterone in postmenopausal women. J Clin Pharmacol 2005 ; 45 : 177-84 (Pubitemid 40490441)
49. Worboys S, Kotsopoulos D, Teede H, McGrath BP, Davis SR. Parental testosterone improves endothelium-dependent and independent vasodilation in postmenopausal women already receiving estrogen. J Clin Endocrinol Metab 2001 ; 86 : 158-61 (Pubitemid 32109790)
50. Lellamo F, Volterrani M, Caminiti G, et al. Testosterone therapy in women with chronic heart failure: A pilot double-blind, randomized, placebo-controlled study. J Am Coll Cardiol 2010 ; 56 : 1310-16
51. Braunstein GD, Sundwall DA, Katz M, et al. Safety and Efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: A randomized, placebo-controlled trial. Arch Intern Med 2005 ; 165 : 1582-9 (Pubitemid 41124151)
52. Davis S R, Goldstat R, Papalia M A, et a l. Effects of aromatase inhibition on sexual function and wellbeing in postmenopausal women treated with testosterone: A randomized placebo controlled trial. Menopause 2006 ; 13 : 37-45
53. Chiuve SE, Martin LA, Campos H, Sacks FM. Effect of the combination of methyltestosterone and esterifi ed estrogens compared with esterifi ed estrogens alone on apolipoprotein CIII and other apolipoproteins in very low density, low density, and high density lipoproteins in surgically postmenopausal women. J Clin Endocrinol Metab 2004 ; 89 : 2207-13 (Pubitemid 38619854)
54. Wagner J D, Zhang L, Williams J K, et a l. E sterifi ed estrogens with and without methyltesterone decrease arterial LDL metabolism in Cynomolgus monekys. Arteriosclerosis,Thrombosis & Vascular Biol 1996 ; 16 : 1473-80 (Pubitemid 26427600)
55. Zang H, Carlstrom K, Arner P, Hirschberg AL. Effects of treatment with testosterone alone or in combination with estrogen on insulin sensitivity in postmenopausal women. Fertil Steril 2006 ; 86 : 136-44 (Pubitemid 43962962)
56. Ding E L, Song Y, Manson J E, et a l. S ex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009 ; 361 : 1152-63
57. Nestler JE, Strauss JF 3rd. Insulin as an effector of human ovarian and adrenal steroid metabolism. Endocrinol Metab Clin North Am 1991 ; 20 : 807-23
58. Janssen I, Powell L H, Kazlauskaite R, Dugan S A. T estosterone and visceral fat in midlife women: The Study of Women's Health Across the Nation (SWAN) fat patterning study. Obesity (Silver Spring) 2010 ; 18 : 604-10
59. Calderon-Margalit R, Schwartz SM, Wellons MF, et al. Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women: The'Coronary Artery Risk Development in Young Adults'women's study. J Clin Endocrinol Metab 2010 ; 95 : 4424-31
60. Ouyang P, Vaidya D, Dobs A, et al. Sex hormone levels and subclinical atherosclerosis in postmenopausal women: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2009 ; 204 : 255-61
61. Worsley R, Robinson PJ, Bell RJ, Moufarage A, Davis SR. Endogenous estrogen and androgen levels are not independent predictors of lipid levels in postmenopausal women. Menopause 2013 March 25. Epub ahead of print
62. Selva D M, Hogeveen K N, Innis S M, Hammond G L. Monosaccharideinduced lipogenesis regulates the human hepatic sex hormonebinding globulin gene. J Clin Invest 2007 ; 117 : 3979-87 (Pubitemid 350224107)
63. Bixo M, Backstrom T, Winblad B, Andersson A. Estradiol and testosterone in specifi c regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 1995 ; 55 : 297-303 (Pubitemid 26017218)
64. Pike CJ, Carroll JC, Rosario ER, Barron AM. Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol 2009 ; 30 : 239-58
65. Moller MC, Bartfai AB, Radestad AF. Effects of testosterone and estrogen replacement on memory function. Menopause 2010 ; 17 : 983-9
66. Wisniewski A, Ngyuen T, Dobs A S. E valuation of high-dose estrogen and high-dose estrogen plus methyltestosterone treatment on cognitive task performance in postmenopausal women. Horm Res 2002 ; 58 : 150-5
67. Shah S M, Bell R J, Savage G, et a l. T estosterone aromatization and cognition in women: A randomized placebo controlled trial. Menopause 2006 ; 13 : 600-8 (Pubitemid 44079530)
68. Davison SL, Bell RJ, Gavrilescu M, et al. Testosterone improves verbal learning and memory in postmenopausal women: Results from a pilot study. Maturitas 2011 ; 70 : 307-11
69. Tamimi RM, Hankinson SE, Chen WY, Rosner B, Colditz GA. Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med 2006 ; 166 : 1483-9 (Pubitemid 44125867)
70. Jick SS, Hagberg KW, Kaye JA, Jick H. Postmenopausal estrogencontaining hormone therapy and the risk of breast cancer. Obstet Gynecol 2009 ; 113 : 74-80
71. Ness R B, Albano J, McTiernan A, Cauley J. I nfl uence of estrogen plus testosterone supplementation on breast cancer. Arch Intern Med 2009 ; 169 : 41-6
72. Dimitrakakis C, Jones R, Liu A, Bondy CA. Breast cancer incidence in postmenopausal women using testosterone in addition to usual hormone therapy. Menopause 2004 ; 11 : 531-5 (Pubitemid 40362151)
73. Davis S R, Wolfe R, Farrugia H, Ferdinand A, Bell R J. T he incidence of invasive breast cancer among women prescribed testosterone for low libido. J Sex Med 2009 ; 6 : 1850-6
74. Chittenden BG, Fullerton G, Maheshwari A, Bhattacharya S. Polycystic ovary syndrome and the risk of gynaecological cancer: A systematic review. Reprod Biomed Online 2009 ; 19 : 398-405
75. Somboonporn W, Davis S, Seif M, Bell R. T estosterone for periand postmenopausal women. Cochrane Database Syst Rev 2005, updated 2009 : CD004509
76. Eden J A. A pilot study of Andro-feme cream (1% testosterone). Proceedings of the 4th Annual Congress of the Australasian Menopause Society, Adelaide, Australia, 2000
77. Snabes M C, Simes SM. Approved hormonal treatments for HSDD: An unmet medical need. J Sex Med 2009 ; 6 : 1846-9
78. Shabsigh R, Duval S, Shah M, Regan TS, Juhasz M, Veltry LG. Efficacy of vardenafi l for the treatment of erectile dysfunction in men with hypertension: A meta-Analysis of clinical trial data. Curr Med Res Opin 2007 ; 23 : 2453-60 (Pubitemid 350033447)
79. Donatucci C, Eardley I, Buvat J, et al. Vardenafi l improves erectile function in men with erectile dysfunction irrespective of disease severity and disease classifi cation. J Sex Med 2004 ; 1 : 301-9 (Pubitemid 40424639)