Endogenous estrogen and androgen levels are not independent predictors of lipid levels in postmenopausal women

Menopause

Volumn 20, Issue 6, 2013, Pages 640-645

  Worsley, Roisin ^a   Robinson, Penelope J ^a   Bell, Robin J ^a   Moufarege, Alain ^b   Davis, Susan R ^a  

^a MONASH UNIVERSITY   (Australia)

^b Private Dermatology Practice   (France)

Author keywords

Cardiovascular disease risk; Lipids; Menopause; Sex steroids

Indexed keywords

ANDROGEN; ANDROSTANOLONE; ANTILIPEMIC AGENT; ESTRADIOL; ESTROGEN; ESTRONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; ANDROGEN BLOOD LEVEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; ESTRADIOL BLOOD LEVEL; ESTROGEN BLOOD LEVEL; ESTRONE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MENOPAUSE; POSTMENOPAUSE; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ANDROGENS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; DIHYDROTESTOSTERONE; ESTRADIOL; ESTROGENS; ESTRONE; FEMALE; HUMANS; INSULIN RESISTANCE; LINEAR MODELS; LIPIDS; MIDDLE AGED; POSTMENOPAUSE; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; TRIGLYCERIDES;

EID: 84879164713     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/gme.0b013e318279bd4a     Document Type: Article

References (32)

1. Rosengren A, Hawken S, Ounpuu S, et al. Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): Casecontrol study. Lancet 2004;364:953-962.
2. Wu FC, von Eckardstein A. Androgens and coronary artery disease. Endocr Rev 2003;24:183-217.
3. Patel SM, Ratcliffe SJ, Reilly MP, et al. Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2009; 94:4776-4784.
4. Bernini GP, Sgro M, Moretti A, et al. Endogenous androgens and carotid intimal-medial thickness in women. J Clin Endocrinol Metab 1999;84: 2008-2012.
5. Worboys S, Kotsopoulos D, Teede H, McGrath B, Davis SR. Evidence that parenteral testosterone therapy may improve endothelium-dependent and-independent vasodilation in postmenopausal women already receiving estrogen. J Clin Endocrinol Metab 2001;86:158-161.
6. Naessen T, Sjogren U, Bergquist J, Larsson M, Lind L, Kushnir MM. Endogenous steroids measured by high-specificity liquid chromatographytandem mass spectrometry and prevalent cardiovascular disease in 70-yearold men and women. J Clin Endocrinol Metab 2010;95:1889-1897.
7. Bell RJ, Davison SL, Papalia MA, McKenzie DP, Davis SR. Endogenous androgen levels and cardiovascular risk profile in women across the adult life span. Menopause 2007;14:630-638.
8. Maggio M, Lauretani F, Ceda GP, et al. Association of hormonal dysregulation with metabolic syndrome in older women: Data from the InCHIANTI study. Am J Physiol Endocrinol Metab 2007;292:E353-E358.
9. Ding EL, Song Y, Manson JE, et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009;361:1152-1163.
10. Ouyang P, Vaidya D, Dobs A, et al. Sex hormone levels and subclinical atherosclerosis in postmenopausal women: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2009;204:255-261.
11. Calderon-Margalit R, Schwartz SM, Wellons MF, et al. Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women: The BCoronary Artery Risk Development in Young Adults[ women's study. J Clin Endocrinol Metab 2010;95:4424-4431.
12. Davis SR, Moreau M, Kroll R, et al. Testosterone for low libido in menopausal women not taking estrogen therapy. N Engl J Med 2008;359: 2005-2017.
13. Diamanti-Kandarakis E, Kouli C, Alexandraki K, Spina G. Failure of mathematical indices to accurately assess insulin resistance in lean, overweight, or obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004;89:1273-1276.
14. Buster JE, Kingsberg SA, Aguirre O, et al. Testosterone patch for low sexual desire in surgically menopausal women: A randomized trial. Obstet Gynecol 2005;105:944-952.
15. Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005;90:5226-5233.
16. Braunstein GD, Sundwall DA, Katz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: A randomized, placebo-controlled trial. Arch Intern Med 2005;165:1582-1589.
17. McTiernan A, Rajan KB, Tworoger SS, et al. Adiposity and sex hormones in postmenopausal breast cancer survivors. J Clin Oncol 2003;21: 1961-1966.
18. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study. Circulation 1983;67:968-977.
19. Garg A, Helderman JH, Koffler M, Ayuso R, Rosenstock J, Raskin P. Relationship between lipoprotein levels and in vivo insulin action in normal young white men. Metabolism 1988;37:982-987.
20. Garvey WT, Kwon S, Zheng D, et al. Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. Diabetes 2003;52:453-462.
21. Matthews KA, Crawford SL, Chae CU, et al. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? J Am Coll Cardiol 2009;54: 2366-2373.
22. Bittner V. NonYhigh-density lipoprotein cholesterol: An alternate target for lipid-lowering therapy. Prev Cardiol 2004;7:122-126.
23. Zavaroni I, Dall'Aglio E, Alpi O, et al. Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride. Atherosclerosis 1985;55:259-266.
24. O'Brien T, Nguyen TT, Zimmerman BR. Hyperlipidemia and diabetes mellitus. Mayo Clin Proc 1998;73:969-976.
25. Abate N, Vega GL, Garg A, Grundy SM. Abnormal cholesterol distribution among lipoprotein fractions in normolipidemic patients with mild NIDDM. Atherosclerosis 1995;118:111-122.
26. Golden SH, Ding J, Szklo M, Schmidt MI, Duncan BB, Dobs A. Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: The atherosclerosis risk in communities study. Am J Epidemiol 2004;160:540-548.
27. Sutton-Tyrrell K, Wildman RP,Matthews KA, et al. Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation 2005;111: 1242-1249.
28. Barrett-Connor E, Goodman-Gruen D. Prospective study of endogenous sex hormones and fatal cardiovascular disease in postmenopausal women. BMJ 1995;311:1193-1196.
29. Janssen I, Powell LH, Kazlauskaite R, Dugan SA. Testosterone and visceral fat in midlife women: The Study of Women-s Health Across the Nation (SWAN) fat patterning study. Obesity (Silver Spring) 2010;18: 604-610.
30. Wildman RP, Wang D, Fernandez I, et al. Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women [epub ahead of print April 30, 2012]. Obesity 2012. doi: 10.1038/oby.2012.109.
31. Kahn SM, Hryb DJ, Nakhla AM, Romas NA, Rosner W. Sex hormoneY binding globulin is synthesized in target cells. J Endocrinol 2002;175: 113-120.
32. Nestler JE. Metformin for the treatment of the polycystic ovary syndrome. N Engl J Med 2008;358:47-54.