A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure

Journal of Thoracic and Cardiovascular Surgery

Volumn 146, Issue 2, 2013, Pages 413-421

  Shirasaka, Tomonori ^a   Miyagawa, Shigeru ^b   Fukushima, Satsuki ^b   Saito, Atsuhiro ^b   Shiozaki, Motoko ^b   Kawaguchi, Naomasa ^c   Matsuura, Nariaki ^c   Nakatani, Satoshi ^c   Sakai, Yoshiki ^d   Daimon, Takashi ^e   Okita, Yutaka ^a   Sawa, Yoshiki ^b  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d ONO PHARMACEUTICAL CO   (Japan)

^e HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

DCM; Dd; dilated cardiomyopathy; Ds; E; E ; early diastolic velocity of the mitral annulus; early transmitral filling wave; EDWT; EF; ejection fraction; ELISA; end diastolic left ventricular dimension; end diastolic wall thickness; end systolic left ventricular dimension; end systolic wall thickness; enzyme linked immunosorbent assay; ESWT; hepatocyte growth factor; HGF; left ventricular (ventricle); LV; messenger RNA; mRNA; ONO1301SR; PCR; PLGA; polylactic and glycolic acid polymer; polymerase chain reaction; SDF 1; slow releasing form of ONO1301; stromal derived factor 1; vascular endothelial growth factor; VEGF

Indexed keywords

7,8 DIHYDRO 5 [2 [[ALPHA (3 PYRIDYL)BENZYLIDENE]AMINOOXY]ETHYL] 1 NAPHTHYLOXYACETIC ACID; COLLAGEN; MESSENGER RNA; POLYGLYCOLIC ACID; POLYLACTIC ACID; SCATTER FACTOR; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DOG; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; FIBROBLAST; HEART CATHETERIZATION; HEART FAILURE; HEART FUNCTION; HEART MUSCLE; HEART MUSCLE CELL; HEART PACING; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

16; 22; 39; 39.2; DCM; DD; DILATED CARDIOMYOPATHY; DS; E; E′; EARLY DIASTOLIC VELOCITY OF THE MITRAL ANNULUS; EARLY TRANSMITRAL FILLING WAVE; EDWT; EF; EJECTION FRACTION; ELISA; END-DIASTOLIC LEFT VENTRICULAR DIMENSION; END-DIASTOLIC WALL THICKNESS; END-SYSTOLIC LEFT VENTRICULAR DIMENSION; END-SYSTOLIC WALL THICKNESS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESWT; HEPATOCYTE GROWTH FACTOR; HGF; LEFT VENTRICULAR (VENTRICLE); LV; MESSENGER RNA; MRNA; ONO1301SR; PCR; PLGA; POLYLACTIC AND GLYCOLIC ACID POLYMER; POLYMERASE CHAIN REACTION; SDF-1; SLOW RELEASING FORM OF ONO1301; STROMAL-DERIVED FACTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR; VEGF;

ANIMALS; CARDIAC CATHETERIZATION; CARDIAC PACING, ARTIFICIAL; CARDIOMYOPATHY, DILATED; CARDIOVASCULAR AGENTS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; CYTOKINES; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; ECHOCARDIOGRAPHY, DOPPLER; FIBROBLASTS; HEART FAILURE; HUMANS; INJECTIONS, INTRAMUSCULAR; LACTIC ACID; MICROSCOPY, ELECTRON; MITOCHONDRIA, HEART; MYOCARDIUM; POLYGLYCOLIC ACID; PYRIDINES; RECOVERY OF FUNCTION; RNA, MESSENGER; STROKE VOLUME; TIME FACTORS; UP-REGULATION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84880261815     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2012.10.003     Document Type: Article

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