Expression of B and T lymphocyte attenuator (BTLA) in macrophages contributes to the fulminant hepatitis caused by murine hepatitis virus strain-3

Gut

Volumn 62, Issue 8, 2013, Pages 1204-1213

  Yang, Chengying ^a   Chen, Yongwen ^a   Guo, Guoning ^a   Li, Hong ^a   Cao, Dayan ^a   Xu, Huan ^a   Guo, Sheng ^a   Fei, Lei ^a   Yan, Weiming ^b   Ning, Qing ^b   Zheng, Lixin ^c   Wu, Yuzhang ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; B AND T LYMPHOCYTE ATTENUATOR; FIBRINOGEN; FIBRINOGEN LIKE PROTEIN 2; PLASMA PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; B LYMPHOCYTE; CELL FUNCTION; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME SYNTHESIS; HEPATITIS; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LIVER INJURY; MACROPHAGE; MORPHOLOGY; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PURIFICATION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN INJURY; SURVIVAL RATE; T LYMPHOCYTE; TISSUE INJURY; VIRUS REPLICATION; VIRUS TITRATION;

ACUTE LIVER FAILURE; BTLA; CELL BIOLOGY; CELLULAR IMMUNITY; CELLULAR IMMUNOLOGY; FGL2; FULMINANT VIRAL HEPATITIS; HEPATOBILIARY PATHOLOGY; IMMUNE; IMMUNE-MEDIATED LIVER DAMAGE; IMMUNOLOGY; IMMUNOLOGY IN HEPATOLOGY; INFECTIOUS DISEASE; INFLAMMATION; INFLAMMATORY MECHANISMS; TNFΑ; VITAMINS;

ADOPTIVE TRANSFER; ANIMALS; APOPTOSIS; CORONAVIRUS INFECTIONS; HEPATITIS, VIRAL, ANIMAL; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MURINE HEPATITIS VIRUS; RECEPTORS, IMMUNOLOGIC; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880253499     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-302239     Document Type: Article

References (29)

1. Hugo RR, Martin P. Viral hepatitis in the liver transplant recipient. Infect Dis Clin North Am 2000;14:761-84.
2. Liu M, Chan CW, McGilvray I, et al. Fulminant viral hepatitis: molecular and cellular basis, and clinical implications. Expert Rev Mol Med 2001;2001:1-19.
3. Levy GA, Leibowitz JL, Edgington TS. Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice. J Exp Med 1981;154:1150-63.
4. Ding JW, Ning Q, Liu MF, et al. Fulminant hepatic failure in murine hepatitis virus strain 3 infection: tissue-specific expression of a novel fgl2 prothrombinase. J Virol 1997;71:9223-30.
5. Marsden PA, Ning Q, Fung LS, et al. The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. J Clin Invest 2003;112:58-66.
6. Li C, Fung LS, Chung S, et al. Monoclonal anti-prothrombinase (3D4.3) prevents mortality from murine hepatitis virus infection (MHV-3). J Exp Med 1992;176:689-97.
7. Watanabe N, Gavrieli M, Sedy JR, et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 2003;4:670-9.
8. Deppong C, Juehne TI, Hurchla M, et al. Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation. J Immunol 2006;176:3909-13.
9. Oya Y, Watanabe N, Owada T, et al. Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator. Arthritis Rheum 2008;58:2498-510.
10. Tao R, Wang L, Han R, et al. Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J Immunol 2005;175:5774-82.
11. Serriari NE, Gondois-Rey F, Guillaume Y, et al. B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function. J Immunol 2010;185:3140-8.
12. Sun Y, Brown NK, Ruddy MJ, et al. B and T lymphocyte attenuator tempers early infection immunity. J Immunol 2009;183:1946-51.
13. Sedy JR, Gavrieli M, Potter KG, et al. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol 2005;6:90-8.
14. Gavrieli M, Watanabe N, Loftin SK, et al. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. Biochem Biophys Res Commun 2003;312:1236-43.
15. Wu TH, Zhen Y, Zeng C, et al. B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation. Immunol Cell Biol 2007;85:590-5.
16. Chen Y, Wu S, Guo G, et al. Programmed death (PD)-1-deficient mice are extremely sensitive to murine hepatitis virus strain-3 (MHV-3) infection. PLoS Pathog 2011;7: e1001347.
17. Belyavsky M, Belyavskaya E, Levy GA, et al. Coronavirus MHV-3-induced apoptosis in macrophages. Virology 1998;250:41-9.
18. Pope M, Rotstein O, Cole E, et al. Pattern of disease after murine hepatitis virus strain 3 infection correlates with macrophage activation and not viral replication. J Virol 1995;69:5252-60.
19. Macnaughton MR, Patterson S. Mouse hepatitis virus strain 3 infection of C57, A/ Sn and A/J strain mice and their macrophages. Brief report. Arch Virol 1980;66:71-5.
20. McGilvray ID, Lu Z, Wei AC, et al. Murine hepatitis virus strain 3 induces the macrophage prothrombinase fgl-2 through p38 mitogen-activated protein kinase activation. J Biol Chem 1998;273:32222-9.
21. Bang FB, Warwick A. Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis of their susceptibility. Proc Natl Acad Sci U S A 1960;46:1065-9.
22. Cheung TC, Steinberg MW, Oborne LM, et al. Unconventional ligand activation of herpesvirus entry mediator signals cell survival. Proc Natl Acad Sci U S A 2009;106:6244-9.
23. Hurchla MA, Sedy JR, Murphy KM. Unexpected role of B and T lymphocyte attenuator in sustaining cell survival during chronic allostimulation. J Immunol 2007;178:6073-82.
24. Steinberg MW, Turovskaya O, Shaikh RB, et al. A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med 2008;205:1463-76.
25. Lepenies B, Pfeffer K, Hurchla MA, et al. Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria. J Immunol 2007;179:4093-100.
26. Ning Q, Brown D, Parodo J, et al. Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response. J Immunol 1998;160:3487-93.
27. Krzystyniak K, Dupuy JM. Early interaction between mouse hepatitis virus 3 and cells. J Gen Virol 1981;57:53-61.
28. Marquis JF, Gros P. Genetic analysis of resistance to infections in mice: a/J meets C57BL/6J. Curr Top Microbiol Immunol 2008;321:27-57.
29. Adler G, Steeg C, Pfeffer K, et al. B and T lymphocyte attenuator restricts the protective immune response against experimental malaria. J Immunol 2011;187: 5310-19.