메뉴 건너뛰기




Volumn 9, Issue 7, 2013, Pages 939-948

Pomalidomide in the treatment of relapsed multiple myeloma

Author keywords

IMiD; multiple myeloma; pomalidomide; refractory; relapsed

Indexed keywords

BORTEZOMIB; CYCLOPHOSPHAMIDE; DEXAMETHASONE; LENALIDOMIDE; POMALIDOMIDE; PREDNISONE;

EID: 84880249695     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.13.105     Document Type: Article
Times cited : (3)

References (77)
  • 1
    • 8944220233 scopus 로고    scopus 로고
    • A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma
    • Attal M, Harousseau JL, Stoppa AM et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. N. Engl. J. Med. 335(2), 91-97 (1996).
    • (1996) N. Engl. J. Med. , vol.335 , Issue.2 , pp. 91-97
    • Attal, M.1    Harousseau, J.L.2    Stoppa, A.M.3
  • 2
    • 0037739753 scopus 로고    scopus 로고
    • High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma
    • Child JA, Morgan GJ, Davies FE et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N. Engl. J. Med. 348(19), 1875-1883 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , Issue.19 , pp. 1875-1883
    • Child, J.A.1    Morgan, G.J.2    Davies, F.E.3
  • 3
    • 0032748385 scopus 로고    scopus 로고
    • Anti-tumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R et al. Anti-tumor activity of thalidomide in refractory multiple myeloma. N. Engl. J. Med. 341(21), 1565-1571 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , Issue.21 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 4
    • 33644831033 scopus 로고    scopus 로고
    • Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the eastern cooperative oncology group
    • Rajkumar SV, Blood E, Vesole D, Fonseca R, Griepp PR. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the Eastern Cooperative Oncology Group. J. Clin. Oncol. 24(3), 431-436 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.3 , pp. 431-436
    • Rajkumar, S.V.1    Blood, E.2    Vesole, D.3    Fonseca, R.4    Griepp, P.R.5
  • 5
    • 20444433230 scopus 로고    scopus 로고
    • Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    • Richardson PG, Sonneveld P, Schuster MW et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N. Engl. J. Med. 352(24), 2487-2498 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , Issue.24 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 6
    • 27744492561 scopus 로고    scopus 로고
    • Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
    • Rajkumar SV, Hayman SR, Lacy MQ et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood 106(13), 4050-4053 (2005).
    • (2005) Blood , vol.106 , Issue.13 , pp. 4050-4053
    • Rajkumar, S.V.1    Hayman, S.R.2    Lacy, M.Q.3
  • 7
    • 4344693453 scopus 로고    scopus 로고
    • Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma
    • Schey SA, Fields P, Bartlett JB et al. Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma. J. Clin. Oncol. 22(16), 3269-3276 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.16 , pp. 3269-3276
    • Schey, S.A.1    Fields, P.2    Bartlett, J.B.3
  • 8
    • 40449135275 scopus 로고    scopus 로고
    • Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation
    • Streetly MJ, Gyertson K, Daniel Y, Zeldis JB, Kazmi M, Schey SA. Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation. Br. J. Haematol. 141(1), 41-51 (2008).
    • (2008) Br. J. Haematol. , vol.141 , Issue.1 , pp. 41-51
    • Streetly, M.J.1    Gyertson, K.2    Daniel, Y.3    Zeldis, J.B.4    Kazmi, M.5    Schey, S.A.6
  • 9
    • 84880223547 scopus 로고    scopus 로고
    • A Phase 1/2 multi-center, randomized, open-label, dose escalation study to determine the maximum tolerated dose, safety, and efficacy of pomalidomide alone or in combination with low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (MM) who have received prior treatment that includes lenalidomide and bortezomib
    • France 3-6 May 2011.
    • Richardson P, Siegel D, Baz R et al. A Phase 1/2 multi-center, randomized, open-label, dose escalation study to determine the maximum tolerated dose, safety, and efficacy of pomalidomide alone or in combination with low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (MM) who have received prior treatment that includes lenalidomide and bortezomib. Presented at: 13th International Myeloma Workshop. Paris, France, 3-6 May 2011.
    • Presented at: 13th International Myeloma Workshop. Paris
    • Richardson, P.1    Siegel, D.2    Baz, R.3
  • 10
    • 84880217564 scopus 로고    scopus 로고
    • Impact of pom + lodex on disease parameters and cytogenetic status in relapsed and refractory multiple myeloma (rrmm)
    • Kyoto Japan 3-7 April 2013.
    • Richardson PG, Lonial S, Jakubowiak A et al. Impact of POM + LoDEX on disease parameters and cytogenetic status in relapsed and refractory multiple myeloma (RRMM). Presented at: 14th International Myeloma Workshop. Kyoto, Japan, 3-7 April 2013.
    • Presented At: 14th International Myeloma Workshop
    • Richardson, P.G.1    Lonial, S.2    Jakubowiak, A.3
  • 11
    • 84884702467 scopus 로고    scopus 로고
    • Pomalidomide (POM) with or without low-dose dexamethasone (LoDEX) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): Outcomes in pts refractory to lenalidomide (LEN) and/or bortezomib (BORT)
    • Chicago, IL, USA 1-5 June
    • Vij R, Richardson PG, Jagannath S et al. Pomalidomide (POM) with or without low-dose dexamethasone (LoDEX) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): Outcomes in pts refractory to lenalidomide (LEN) and/or bortezomib (BORT). Presented at: American Society of Clinical Oncology Annual Meeting. Chicago, IL, USA, 1-5 June 2012.
    • (2012) Presented at: American Society of Clinical Oncology Annual Meeting
    • Vij, R.1    Richardson, P.G.2    Jagannath, S.3
  • 12
    • 84884703339 scopus 로고    scopus 로고
    • Pomalidomide (POM) with low-dose dexamethasone (LoDex) in patients (Pts) with relapsed and refractory multiple myeloma who have received prior therapy with lenalidomide (LEN) and bortezomib (BORT): Updated Phase 2 results and age subgroup analysis
    • Atlanta, GA, USA 8-11 December
    • Jagannath S, Hofmeister C, Siegel D et al. Pomalidomide (POM) with low-dose dexamethasone (LoDex) in patients (Pts) with relapsed and refractory multiple myeloma who have received prior therapy with lenalidomide (LEN) and bortezomib (BORT): Updated Phase 2 results and age subgroup analysis. Presented at: American Society of Hematology Annual Meeting. Atlanta, GA, USA, 8-11 December 2012.
    • (2012) Presented at: American Society of Hematology Annual Meeting
    • Jagannath, S.1    Hofmeister, C.2    Siegel, D.3
  • 13
    • 84877622448 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide-refractory multiple myeloma Intergroupe Francophone du Myélome 2009 02
    • Leleu X, Attal M, Arnulf B et al. Pomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide-refractory multiple myeloma: Intergroupe Francophone du Myélome 2009-02. Blood 121(11), 1968-1975 (2013).
    • (2013) Blood , vol.121 , Issue.11 , pp. 1968-1975
    • Leleu, X.1    Attal, M.2    Arnulf, B.3
  • 14
    • 73849086725 scopus 로고    scopus 로고
    • Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma
    • Lacy MQ, Hayman SR, Gertz MA et al. Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma. J. Clin. Oncol. 27(30), 5008-5014 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.30 , pp. 5008-5014
    • Lacy, M.Q.1    Hayman, S.R.2    Gertz, M.A.3
  • 15
    • 78149468560 scopus 로고    scopus 로고
    • Pomalidomide (CC4047) plus low dose dexamethasone (Pom/Dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)
    • Lacy MQ, Hayman SR, Gertz MA et al. Pomalidomide (CC4047) plus low dose dexamethasone (Pom/Dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM). Leukemia 24(11), 1934-1939 (2010).
    • (2010) Leukemia , vol.24 , Issue.11 , pp. 1934-1939
    • Lacy, M.Q.1    Hayman, S.R.2    Gertz, M.A.3
  • 16
    • 80052937408 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: Comparison of 2 dosing strategies in dual-refractory disease
    • Lacy MQ, Allred JB, Gertz MA et al. Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: Comparison of 2 dosing strategies in dual-refractory disease. Blood 118(11), 2970-2975 (2011).
    • (2011) Blood , vol.118 , Issue.11 , pp. 2970-2975
    • Lacy, M.Q.1    Allred, J.B.2    Gertz, M.A.3
  • 17
    • 84880221530 scopus 로고    scopus 로고
    • Enhanced activity of pomalidomide and dexamethasone in relapsed refractory myeloma irrespective to efficacy in their last prior line of therapy
    • Amsterdam The Netherlands 14-17 June 2012.
    • Leleu XL, Roussel MR, Arnulf BA et al. Enhanced activity of pomalidomide and dexamethasone in relapsed refractory myeloma irrespective to efficacy in their last prior line of therapy. Presented at: 17th Congress of the European Hematology Association. Amsterdam, The Netherlands, 14-17 June 2012.
    • Presented at: 17th Congress of the European Hematology Association
    • Leleu, X.L.1    Roussel, M.R.2    Arnulf, B.A.3
  • 18
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • Kumar SK, Rajkumar SV, Dispenzieri A et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 111(5), 2516-2520 (2008).
    • (2008) Blood , vol.111 , Issue.5 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispenzieri, A.3
  • 19
    • 84860709392 scopus 로고    scopus 로고
    • Lenalidomide maintenance after stem-cell transplantation for multiple myeloma
    • Attal M, Lauwers-Cances V, Marit G et al. Lenalidomide maintenance after stem-cell transplantation for multiple myeloma. N. Engl. J. Med. 366(19), 1782-1791 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.19 , pp. 1782-1791
    • Attal, M.1    Lauwers-Cances, V.2    Marit, G.3
  • 20
    • 84860741191 scopus 로고    scopus 로고
    • Lenalidomide after stem-cell transplantation for multiple myeloma
    • McCarthy PL, Owzar K, Hofmeister CC et al. Lenalidomide after stem-cell transplantation for multiple myeloma. N. Engl. J. Med. 366(19), 1770-1781 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.19 , pp. 1770-1781
    • McCarthy, P.L.1    Owzar, K.2    Hofmeister, C.C.3
  • 21
    • 84860744403 scopus 로고    scopus 로고
    • Continuous lenalidomide treatment for newly diagnosed multiple myeloma
    • Palumbo A, Hajek R, Delforge M et al. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N. Engl. J. Med. 366(19), 1759-1769 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.19 , pp. 1759-1769
    • Palumbo, A.1    Hajek, R.2    Delforge, M.3
  • 22
    • 84877620340 scopus 로고    scopus 로고
    • BiRD (clarithromycin, lenalidomide, dexamethasone): An update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma
    • Rossi A, Mark T, Jayabalan D et al. BiRD (clarithromycin, lenalidomide, dexamethasone): An update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma. Blood 121(11), 1982-1985 (2011).
    • (2011) Blood , vol.121 , Issue.11 , pp. 1982-1985
    • Rossi, A.1    Mark, T.2    Jayabalan, D.3
  • 23
    • 84856719479 scopus 로고    scopus 로고
    • Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter International Myeloma Working Group study
    • Kumar SK, Lee JH, Lahuerta JJ et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter International Myeloma Working Group study. Leukemia 26(1), 149-157 (2012).
    • (2012) Leukemia , vol.26 , Issue.1 , pp. 149-157
    • Kumar, S.K.1    Lee, J.H.2    Lahuerta, J.J.3
  • 24
    • 84864561961 scopus 로고    scopus 로고
    • Whole genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution and clonal tides
    • Egan JB, Shi CX, Tembe W et al. Whole genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution and clonal tides. Blood 120(5), 1060-1066 (2012).
    • (2012) Blood , vol.120 , Issue.5 , pp. 1060-1066
    • Egan, J.B.1    Shi, C.X.2    Tembe, W.3
  • 25
    • 33748564972 scopus 로고    scopus 로고
    • Immune parameters in multiple myeloma patients: Influence of treatment and correlation with opportunistic infections
    • Schutt P, Brandhorst D, Stellberg W et al. Immune parameters in multiple myeloma patients: Influence of treatment and correlation with opportunistic infections. Leuk. Lymphoma 47(8), 1570-1582 (2006).
    • (2006) Leuk. Lymphoma , vol.47 , Issue.8 , pp. 1570-1582
    • Schutt, P.1    Brandhorst, D.2    Stellberg, W.3
  • 26
    • 34547677725 scopus 로고    scopus 로고
    • Immunodeficiency and immunotherapy in multiple myeloma
    • Pratt G, Goodyear O, Moss P. Immunodeficiency and immunotherapy in multiple myeloma. Br. J. Haematol. 138(5), 563-579 (2007).
    • (2007) Br. J. Haematol. , vol.138 , Issue.5 , pp. 563-579
    • Pratt, G.1    Goodyear, O.2    Moss, P.3
  • 27
    • 70349898336 scopus 로고    scopus 로고
    • Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents
    • Nucci M, Anaissie E. Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents. Clin. Infect. Dis. 49(8), 1211-1225 (2009).
    • (2009) Clin. Infect. Dis. , vol.49 , Issue.8 , pp. 1211-1225
    • Nucci, M.1    Anaissie, E.2
  • 28
    • 79951891171 scopus 로고    scopus 로고
    • Renal impairment in patients with multiple myeloma: A consensus statement on behalf of the International Myeloma Working Group
    • Dimopoulos MA, Terpos E, Chanan-Khan A et al. Renal impairment in patients with multiple myeloma: A consensus statement on behalf of the International Myeloma Working Group. J. Clin. Oncol. 28(33), 4976-4984 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.33 , pp. 4976-4984
    • Dimopoulos, M.A.1    Terpos, E.2    Chanan-Khan, A.3
  • 29
    • 34247897361 scopus 로고    scopus 로고
    • Renal failure in multiple myeloma: Incidence, correlations, and prognostic significance
    • Eleutherakis-Papaiakovou V, Bamias A, Gika D et al. Renal failure in multiple myeloma: Incidence, correlations, and prognostic significance. Leuk. Lymphoma 48(2), 337-341 (2007).
    • (2007) Leuk. Lymphoma , vol.48 , Issue.2 , pp. 337-341
    • Eleutherakis-Papaiakovou, V.1    Bamias, A.2    Gika, D.3
  • 30
    • 51049095076 scopus 로고    scopus 로고
    • The effect of chronic renal failure on drug metabolism and transport
    • Dreisbach AW, Lertora JJ. The effect of chronic renal failure on drug metabolism and transport. Expert Opin. Drug Metab. Toxicol. 4(8), 1065-1074 (2008).
    • (2008) Expert Opin. Drug Metab. Toxicol. , vol.4 , Issue.8 , pp. 1065-1074
    • Dreisbach, A.W.1    Lertora, J.J.2
  • 31
    • 35548992822 scopus 로고    scopus 로고
    • Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution
    • Stewart AK, Chang H, Trudel S et al. Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution. Leukemia 21(11), 2358-2359 (2007).
    • (2007) Leukemia , vol.21 , Issue.11 , pp. 2358-2359
    • Stewart, A.K.1    Chang, H.2    Trudel, S.3
  • 32
    • 70249146895 scopus 로고    scopus 로고
    • Single-agent bortezomib in previously untreated multiple myeloma: Efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy
    • Richardson PG, Xie W, Mitsiades C et al. Single-agent bortezomib in previously untreated multiple myeloma: Efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy. J. Clin. Oncol. 27(21), 3518-3525 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.21 , pp. 3518-3525
    • Richardson, P.G.1    Xie, W.2    Mitsiades, C.3
  • 33
    • 20044386503 scopus 로고    scopus 로고
    • Neurological toxicity of long-term (>1 yr) thalidomide therapy in patients with multiple myeloma
    • Tosi P, Zamagni E, Cellini C et al. Neurological toxicity of long-term (>1 yr) thalidomide therapy in patients with multiple myeloma. Eur. J. Haematol. 74(3), 212-216 (2005).
    • (2005) Eur. J. Haematol. , vol.74 , Issue.3 , pp. 212-216
    • Tosi, P.1    Zamagni, E.2    Cellini, C.3
  • 34
    • 74249089972 scopus 로고    scopus 로고
    • Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
    • Quach H, Ritchie D, Stewart AK et al. Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma. Leukemia 24(1), 22-32 (2010).
    • (2010) Leukemia , vol.24 , Issue.1 , pp. 22-32
    • Quach, H.1    Ritchie, D.2    Stewart, A.K.3
  • 35
    • 84876724199 scopus 로고    scopus 로고
    • Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma
    • Zhu YX, Korteum KM, Stewart AK. Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk. Lymphoma 54(4), 683-687 (2013).
    • (2013) Leuk. Lymphoma , vol.54 , Issue.4 , pp. 683-687
    • Zhu, Y.X.1    Korteum, K.M.2    Stewart, A.K.3
  • 36
    • 84880215251 scopus 로고    scopus 로고
    • Overcoming resistance: The use of pomalidomide (pom) and dexamethasone (dex) in re-sensitizing lenalidomide (len)-resistant multiple myeloma (MM) cells
    • Paris France 3-6 May 2011.
    • Rychak E, Mendy D, Miller K et al. Overcoming resistance: The use of pomalidomide (pom) and dexamethasone (dex) in re-sensitizing lenalidomide (len)-resistant multiple myeloma (MM) cells. Presented at: 13th International Myeloma Workshop. Paris, France, 3-6 May 2011.
    • Presented at: 13th International Myeloma Workshop
    • Rychak, E.1    Mendy, D.2    Miller, K.3
  • 37
    • 1942534043 scopus 로고    scopus 로고
    • The evolution of thalidomide and its IMiD derivatives as anticancer agents
    • Bartlett JB, Drege K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat. Rev. Cancer 4(4), 314-322 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.4 , pp. 314-322
    • Bartlett, J.B.1    Drege, K.2    Dalgleish, A.G.3
  • 38
    • 23444447848 scopus 로고    scopus 로고
    • IMiDs: A novel class of immunomodulators
    • Knight R. IMiDs: A novel class of immunomodulators. Semin. Oncol. 32(4 Suppl. 5), 24-30 (2005).
    • (2005) Semin. Oncol. , vol.32 , Issue.4 SUPPL.5 , pp. 24-30
    • Knight, R.1
  • 39
    • 84874110472 scopus 로고    scopus 로고
    • Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration
    • Hoffmann M, Kasserra C, Reyes J et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother. Pharmacol. 71(2), 489-501 (2013).
    • (2013) Cancer Chemother. Pharmacol. , vol.71 , Issue.2 , pp. 489-501
    • Hoffmann, M.1    Kasserra, C.2    Reyes, J.3
  • 40
    • 84859780661 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism and excretion of [14C] lenalidomide following oral administration in healthy male subjects
    • Chen N, Wen L, Lau H, Surapaneni S, Kumar G. Pharmacokinetics, metabolism and excretion of [14C]-lenalidomide following oral administration in healthy male subjects. Cancer Chemother. Pharmacol. 69(3), 789-797 (2012).
    • (2012) Cancer Chemother. Pharmacol. , vol.69 , Issue.3 , pp. 789-797
    • Chen, N.1    Wen, L.2    Lau, H.3    Surapaneni, S.4    Kumar, G.5
  • 41
    • 70349739288 scopus 로고    scopus 로고
    • Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism
    • Escoubet-Lozach L, Lin IL, Jensen-Pergakes K et al. Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism. Cancer Res. 69(18), 7347-7356 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.18 , pp. 7347-7356
    • Escoubet-Lozach, L.1    Lin, I.L.2    Jensen-Pergakes, K.3
  • 42
    • 79955969732 scopus 로고    scopus 로고
    • IMiD immunomodulatory compounds block C/EBPb translation through eIF4E down-regulation resulting in inhibition of MM
    • Li S, Pal R, Monaghan SA et al
    • (2011) Blood , vol.117 , Issue.19 , pp. 5157-5165
    • Li, S.1    Pal, R.2    Monaghan, S.A.3
  • 43
    • 33846665934 scopus 로고    scopus 로고
    • Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells
    • Verhelle D, Corral LG, Wong K et al. Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells. Cancer Res. 67(2), 746-755 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.2 , pp. 746-755
    • Verhelle, D.1    Corral, L.G.2    Wong, K.3
  • 44
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
    • Mitsiades N, Mitsiades CS, Poulaki V et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications. Blood 99(22), 4525-4530 (2002).
    • (2002) Blood , vol.99 , Issue.22 , pp. 4525-4530
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 45
    • 77957774888 scopus 로고    scopus 로고
    • Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myeloma
    • Harousseau JL, Dimopoulos MA, Wang M et al. Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myeloma. Haematologica 95(10), 1738-1744 (2010).
    • (2010) Haematologica , vol.95 , Issue.10 , pp. 1738-1744
    • Harousseau, J.L.1    Dimopoulos, M.A.2    Wang, M.3
  • 46
    • 77950644007 scopus 로고    scopus 로고
    • Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function
    • Gandhi AK, Kang J, Capone L et al. Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. Curr. Cancer Drug Targets 10(2), 155-167 (2010).
    • (2010) Curr. Cancer Drug Targets , vol.10 , Issue.2 , pp. 155-167
    • Gandhi, A.K.1    Kang, J.2    Capone, L.3
  • 47
    • 84878690962 scopus 로고    scopus 로고
    • Enhanced cross-priming of naive CD8+ T cells by DCs treated by the IMiDs® immunomodulatory compounds lenalidomide and pomalidomide
    • doi:10.1111/imm.12087 Epub ahead of print
    • Henry JY, Labarthe MC, Meyer B, Dasgupta P, Dalgleish AG, Galustian C. Enhanced cross-priming of naive CD8+ T cells by DCs treated by the IMiDs® immunomodulatory compounds lenalidomide and pomalidomide. Immunology doi:10.1111/imm.12087 (2013) (Epub ahead of print).
    • (2013) Immunology
    • Henry, J.Y.1    Labarthe, M.C.2    Meyer, B.3    Dasgupta, P.4    Dalgleish, A.G.5    Galustian, C.6
  • 48
    • 67349107194 scopus 로고    scopus 로고
    • The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells
    • Galustian C, Meyer B, Labarthe MC et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunol. Immunother. 58(7), 1033-1045 (2009).
    • (2009) Cancer Immunol. Immunother. , vol.58 , Issue.7 , pp. 1033-1045
    • Galustian, C.1    Meyer, B.2    Labarthe, M.C.3
  • 49
    • 0037093854 scopus 로고    scopus 로고
    • Protective anti-tumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity
    • Dredge K, Marriott JB, Todryk SM et al. Protective anti-tumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity. J. Immunol. 168(10), 4914-4919 (2002).
    • (2002) J. Immunol. , vol.168 , Issue.10 , pp. 4914-4919
    • Dredge, K.1    Marriott, J.B.2    Todryk, S.M.3
  • 50
    • 0033168605 scopus 로고    scopus 로고
    • Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha
    • Corral LG, Haslett PA, Muller GW et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. J. Immunol. 163(1), 380-386 (1999).
    • (1999) J. Immunol. , vol.163 , Issue.1 , pp. 380-386
    • Corral, L.G.1    Haslett, P.A.2    Muller, G.W.3
  • 51
    • 67651111993 scopus 로고    scopus 로고
    • Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases
    • Xu Y, Li J, Ferguson GD et al. Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases. Blood 114(2), 338-345 (2009).
    • (2009) Blood , vol.114 , Issue.2 , pp. 338-345
    • Xu, Y.1    Li, J.2    Ferguson, G.D.3
  • 52
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 98(1), 210-216 (2001).
    • (2001) Blood , vol.98 , Issue.1 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 53
    • 52549088421 scopus 로고    scopus 로고
    • Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation
    • Zhu D, Corral LG, Fleming YW, Stein B. Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation. Cancer Immunol. Immunother. 57(12), 1849-1859 (2008).
    • (2008) Cancer Immunol. Immunother. , vol.57 , Issue.12 , pp. 1849-1859
    • Zhu, D.1    Corral, L.G.2    Fleming, Y.W.3    Stein, B.4
  • 54
    • 77449111211 scopus 로고    scopus 로고
    • Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia
    • Pal R, Monaghan SA, Hassett AC et al. Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia. Blood 115(3), 605-614 (2010).
    • (2010) Blood , vol.115 , Issue.3 , pp. 605-614
    • Pal, R.1    Monaghan, S.A.2    Hassett, A.C.3
  • 55
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: Clinical applications
    • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: Clinical applications. Blood 104(3), 607-618 (2004).
    • (2004) Blood , vol.104 , Issue.3 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 56
    • 0035195019 scopus 로고    scopus 로고
    • Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications
    • Gupta D, Treon SP, Shima Y et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications. Leukemia 15(12), 1950-1961 (2001).
    • (2001) Leukemia , vol.15 , Issue.12 , pp. 1950-1961
    • Gupta, D.1    Treon, S.P.2    Shima, Y.3
  • 57
    • 0034655957 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma
    • Dankbar B, Pado T, Leo R et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood 95(8), 2630-2636 (2000).
    • (2000) Blood , vol.95 , Issue.8 , pp. 2630-2636
    • Dankbar, B.1    Pado, T.2    Leo, R.3
  • 58
    • 84876158316 scopus 로고    scopus 로고
    • The immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple myeloma-induced osteoclast formation and RANKL/OPG ratio in myeloma microenvironment targeting the expression of adhesion molecules
    • Bolzoni M, Storti P, Bonomini S et al. The immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple myeloma-induced osteoclast formation and RANKL/OPG ratio in myeloma microenvironment targeting the expression of adhesion molecules. Exp. Hematol. 41(4), 387-397 (2013).
    • (2013) Exp. Hematol. , vol.41 , Issue.4 , pp. 387-397
    • Bolzoni, M.1    Storti, P.2    Bonomini, S.3
  • 59
    • 60449115552 scopus 로고    scopus 로고
    • The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions
    • Lu L, Payvandi F, Wu L et al. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc. Res. 77(2), 78-86 (2009).
    • (2009) Microvasc. Res. , vol.77 , Issue.2 , pp. 78-86
    • Lu, L.1    Payvandi, F.2    Wu, L.3
  • 60
    • 0037021257 scopus 로고    scopus 로고
    • Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects
    • Dredge K, Marriott JB, Macdonald CD et al. Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects. Br. J. Cancer 87(10), 1166-1172 (2002).
    • (2002) Br. J. Cancer , vol.87 , Issue.10 , pp. 1166-1172
    • Dredge, K.1    Marriott, J.B.2    Macdonald, C.D.3
  • 61
    • 33645736007 scopus 로고    scopus 로고
    • Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1
    • Anderson G, Gries M, Kurihara N et al. Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1. Blood 107(8), 3098-3105 (2006).
    • (2006) Blood , vol.107 , Issue.8 , pp. 3098-3105
    • Anderson, G.1    Gries, M.2    Kurihara, N.3
  • 62
    • 77949350034 scopus 로고    scopus 로고
    • Identification of a primary target of thalidomide teratogenicity
    • Ito T, Ando H, Suzuki T et al. Identification of a primary target of thalidomide teratogenicity. Science 327(5971), 1345-1350 (2010).
    • (2010) Science , vol.327 , Issue.5971 , pp. 1345-1350
    • Ito, T.1    Ando, H.2    Suzuki, T.3
  • 63
    • 84873048466 scopus 로고    scopus 로고
    • High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance
    • Broyl A, Kuiper R, van Duin M et al. High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance. Blood 121(4), 624-627 (2013).
    • (2013) Blood , vol.121 , Issue.4 , pp. 624-627
    • Broyl, A.1    Kuiper, R.2    Van Duin, M.3
  • 64
    • 84869082150 scopus 로고    scopus 로고
    • Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
    • Lopez-Girona A, Mendy D, Ito T et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11), 2326-2335 (2012).
    • (2012) Leukemia , vol.26 , Issue.11 , pp. 2326-2335
    • Lopez-Girona, A.1    Mendy, D.2    Ito, T.3
  • 65
    • 80855156719 scopus 로고    scopus 로고
    • Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
    • Zhu YX, Braggio E, Shi CX et al. Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide. Blood 118(18), 4771-4779(2011).
    • (2011) Blood , vol.118 , Issue.18 , pp. 4771-4779
    • Zhu, Y.X.1    Braggio, E.2    Shi, C.X.3
  • 66
    • 84880237543 scopus 로고    scopus 로고
    • Pomalidomide in combination with low-dose dexamethasone demonstrates a significant progression free survival and overall survival advantage, in relapsed/refractory MM: A Phase 3, multicenter, randomized, open-label study
    • Atlanta, GA, USA 8-11 December 2012.
    • Dimopoulos MA, Lacy MQ, Moreau P et al. Pomalidomide in combination with low-dose dexamethasone demonstrates a significant progression free survival and overall survival advantage, in relapsed/refractory MM: A Phase 3, multicenter, randomized, open-label study. Presented at: American Society of Hematology Meeting. Atlanta, GA, USA, 8-11 December 2012.
    • Presented at: American Society of Hematology Meeting
    • Dimopoulos, M.A.1    Lacy, M.Q.2    Moreau, P.3
  • 67
    • 84880241377 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone (Pom/Dex) in relapsed myeloma: Long term follow up and factors predicting outcome in 345 patients
    • Atlanta, GA, USA 8-11 December 2012.
    • Lacy MQ, LaPlant BR, Laumann K et al. Pomalidomide plus low-dose dexamethasone (Pom/Dex) in relapsed myeloma: Long term follow up and factors predicting outcome in 345 patients. Presented at: American Society of Hematology Meeting. Atlanta, GA, USA, 8-11 December 2012.
    • Presented at: American Society of Hematology Meeting
    • Lacy, M.Q.1    LaPlant, B.R.2    Laumann, K.3
  • 68
    • 84860547342 scopus 로고    scopus 로고
    • Thalidomide versus dexamethasone for the treatment of relapsed and/or refractory multiple myeloma: Results from OPTIMUM, a randomized trial
    • Kropff M, Baylon HG, Hillengass J et al. Thalidomide versus dexamethasone for the treatment of relapsed and/or refractory multiple myeloma: Results from OPTIMUM, a randomized trial. Haematologica 97(5), 784-791 (2012).
    • (2012) Haematologica , vol.97 , Issue.5 , pp. 784-791
    • Kropff, M.1    Baylon, H.G.2    Hillengass, J.3
  • 69
    • 62549132481 scopus 로고    scopus 로고
    • Treatment of newly diagnosed myeloma
    • Palumbo A, Rajkumar SV. Treatment of newly diagnosed myeloma. Leukemia 23(3), 449-456 (2009).
    • (2009) Leukemia , vol.23 , Issue.3 , pp. 449-456
    • Palumbo, A.1    Rajkumar, S.V.2
  • 70
    • 0027451853 scopus 로고
    • Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients
    • Scaglione F, Ferrara F, Dugnani S, Demartini G, Triscari F, Fraschini F. Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients. J. Chemother. 5(4), 228-232 (1993).
    • (1993) J. Chemother. , vol.5 , Issue.4 , pp. 228-232
    • Scaglione, F.1    Ferrara, F.2    Dugnani, S.3    Demartini, G.4    Triscari, F.5    Fraschini, F.6
  • 71
    • 0030063950 scopus 로고    scopus 로고
    • Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells
    • Matsuoka N, Eguchi K, Kawakami A et al. Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells. Clin. Exp. Immunol. 104(3), 501-508 (1996).
    • (1996) Clin. Exp. Immunol. , vol.104 , Issue.3 , pp. 501-508
    • Matsuoka, N.1    Eguchi, K.2    Kawakami, A.3
  • 72
    • 0029126897 scopus 로고
    • Erythromycin suppresses interleukin 6 expression by human bronchial epithelial cells: A potential mechanism of its anti-inflammatory action
    • Takizawa H, Desaki M, Ohtoshi T et al. Erythromycin suppresses interleukin 6 expression by human bronchial epithelial cells: A potential mechanism of its anti-inflammatory action. Biochem. Biophys. Res. Commun. 210(3), 781-786 (1995).
    • (1995) Biochem. Biophys. Res. Commun. , vol.210 , Issue.3 , pp. 781-786
    • Takizawa, H.1    Desaki, M.2    Ohtoshi, T.3
  • 73
    • 14944374754 scopus 로고    scopus 로고
    • Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice
    • Ohara T, Morishita T, Suzuki H, Masaoka T, Ishii H, Hibi T. Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice. Anticancer Res. 24(6), 3723-3730 (2004).
    • (2004) Anticancer Res. , vol.24 , Issue.6 , pp. 3723-3730
    • Ohara, T.1    Morishita, T.2    Suzuki, H.3    Masaoka, T.4    Ishii, H.5    Hibi, T.6
  • 75
    • 84880213428 scopus 로고    scopus 로고
    • ClaPD (clarithromycin, pomalidomide, dexamethasone) therapy in relapsed or refractory multiple myeloma
    • Atlanta, GA, USA 8-11 December 2012.
    • Mark TM, Boyer A, Rossi AC et al. ClaPD (clarithromycin, pomalidomide, dexamethasone) therapy in relapsed or refractory multiple myeloma. Presented at: American Society of Hematology Meeting. Atlanta, GA, USA, 8-11 December 2012.
    • Presented at: American Society of Hematology Meeting
    • Mark, T.M.1    Boyer, A.2    Rossi, A.C.3
  • 76
    • 84880229914 scopus 로고    scopus 로고
    • Pomalidomide cyclophosphamide and Prednisone (PCP) treatment for relapsed/refractory multiple myeloma
    • Atlanta, GA, USA 8-11 December 2012.
    • Palumbo A, Larocca A, Montefusco V et al. Pomalidomide cyclophosphamide and Prednisone (PCP) treatment for relapsed/refractory multiple myeloma. Presented: American Society of Hematology Meeting. Atlanta, GA, USA, 8-11 December 2012.
    • Presented: American Society of Hematology Meeting
    • Palumbo, A.1    Larocca, A.2    Montefusco, V.3
  • 77
    • 84880236399 scopus 로고    scopus 로고
    • MM-005 a Phase 1, multicenter, open-label, dose-escalation study to determine the maximum tolerated dose for the combination of pomalidomide, bortezomib, and low-dose dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma
    • Atlanta, GA, USA 8-11 December 2012.
    • Richardson PG, Hofmeister CC, Siegel D et al. MM-005 a Phase 1, multicenter, open-label, dose-escalation study to determine the maximum tolerated dose for the combination of pomalidomide, bortezomib, and low-dose dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma. Presented at: American Society of Hematology Meeting. Atlanta, GA, USA, 8-11 December 2012.
    • Presented at: American Society of Hematology Meeting
    • Richardson, P.G.1    Hofmeister, C.C.2    Siegel, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.