Phytochemicals and biological studies of plants in genus Hedysarum

Chemistry Central Journal

Volumn 7, Issue 1, 2013, Pages

  Dong, Yinmao ^a,c   Tang, Dongyan ^a   Zhang, Na ^b   Li, Yue ^b   Zhang, Chunhong ^b   Li, Li ^c   Li, Minhui ^b  

^a HARBIN INSTITUTE OF TECHNOLOGY   (China)

^b BAOTOU MEDICAL COLLEGE   (China)

^c BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

Author keywords

Chemical constituents; Hedysarum; Pharmacology; TCM; Utilization

Indexed keywords

EID: 84880184467     PISSN: None     EISSN: 1752153X     Source Type: Journal    
DOI: 10.1186/1752-153X-7-124     Document Type: Review

References (72)

1. Chen DZ: Flora reipublicae popularis sinicae. Beijing: Science Press 1999, 42:180.
2. National Pharmacopoeia Committee: Chinese PharmacopoeiaI. 2010, 142. [China Medical Science and Technology Press]
3. Nechepurenko IV, Polovinka MP, Komarova NI, Korchagina DV, Salakhutdinov NF, Nechepurenko SB: Low-molecular-weight phenolic compounds from Hedysarum theinum roots. Chem Nat Compd 2008, 44:31-34.
4. Liu Y, Yang JS: Studies on chemical constituents isolated from Hedysarum polybotrys . Chin Pharm J 2005, 40:1215-1216.
5. Liu Y, Zhang QY, Zhao YY, Wang B, Hai LQ, Ying YP, Chen HB: Saponins from the roots of Hedysarum polybotrys . Biochem Syst Ecol 2007, 35:389-391.
6. Dang ZL, Liu XH, Zhao AN, Liang JD, Liang J, Liu ZH, Feng SL: Chemical structural features and primary molecular conformation of polysaccharide HPS4-1A from Hedysarum polybotrys. Zhongcaoyao 2013, 44:141-146.
7. Wang W, Liang H, Wang B, Tu GZ, Chen HB, Zhao YY: A new natural product from the roots of Hedysarum multijugum . J Peking University(Health Sciences) 2005, 37:532-535.
8. Chen SG: Master's thesis. Studies on the chemical constituents of Hedysarum scoparium and Inula Hupehensis: Lanzhou University; 2007.
9. Neretina OV, Fedorov SV, Gromova AS, Lutskii VI, El'kin YN: Flavonoids of Hedysarum setigerum . Chem Nat Compd 2002, 38:194-195.
10. Neretina OV, Gromova AS, Lutskii VI, Semenov AA, Ushakov IA, Makar'eva TN, Owen NL: Secondary metabolites from Hedysarum setigerum . Chem Nat Compd 2004, 40:91-92.
11. Glyzina GS, Komissarenko NF: The flavonoids of Hedysarum gmelini . Khim Prir Soedin 1967, 3:116.
12. Glyzina GS, Bykov VI: Phenolic compounds of Hedysarum neglectum . Khim Prir Soedin 1969, 5:272.
13. Komissarenko AN, Nadezhina TP, Komissarenko NZ: Flavonoids and xanthones of Hedysarum connatum and H. alpinum . Chem Nat Compd 1994, 30:521-522.
14. Glyzin VI, Bykov VI, Glyzina GS: The phenolic compounds of Hedysarum komarovii . Khim Prir Soedin 1968, 4:324.
15. Glyzin VI, Ban'kovsii AI, Pavlova HS: Phenolic compounds of Hedysarum sachalinense and H. brandtii . Khim Prir Soedin 1970, 6:372.
16. Alaniya MD: Flavonoids of Hedysarum sericeum and H. caucasicum . Plenum publishing corporation 1983, 19:612-613.
17. Hai LQ, Xu JJ, Kai Sai-er A, Zhang X, Ma LY: Chemical constituents of Hedysanun austrosibuicum b. Fedtsch. Huaxi Yaoxue Zazhi 2006, 21:47-48.
18. Liu Y, Zhang Z, Zhang QY, Pu XP, Zhao YY: Study on chemical constituents and antioxidative activity of Radix Hedysari. China Pharm 2010, 24:543-549.
19. Liu Y, Zhao YY, Chen HB, Wang B, Zhang QY: Chemical analysis of the principal flavonoids of Radix Hedysari by HPLC. Nat Prod Commun 2010, 5:541-544.
20. Liu Y, Chen HB, Zhao YY, Wang B, Zhang QY, Zhang L, Tu PF: Quantification and stability studies on the flavonoids of Radix Hedysari. J Agr Food Chem 2006, 54:6634-6639.
21. Hai LQ, Zhang QY, Liang H, Zhao YY, Du NS: Study on chemical constituents of Hedysarum polybotrys . Acta Pharm Sinica 2003, 38:592-595.
22. Liu Y, Zhao YY, Tu GZ, Chen HB: Flavonoids of the roots of Hedysarum kirghisorum . Biochem Syst Ecol 2005, 33:809-812.
23. Liu Y, Chen HB, Tu GZ, Zhao YY: Studies on the constituents from the Hedysarum kirghisorum . Medicinal Plant Research and Traditional Chinese Medicine Modernization-Fourth National Symposium on Medicinal Botany and Herbal Medicine 2004, 167-169.
24. Liu Y, Hai LQ, Zhao YY: Isoflavonoids from Hedysarum semenovii . Chin Pharm J 2009, 44:1533-1535.
25. Xu JJ, Hai LQ, Wang XQ, Chang JM, Zhang X: Chemical constituents of Hedysarum austrosibiricum b. Fedtsch Huaxi Yaoxue Zazhi 2005, 20:214-215.
26. Nechepurenko IV, Polovinka NP, Sal'nikova OI, Pokrovskii LM, Komarova NI, Salakhutdinov NF, Nechepurenko SB: Components of the ethylacetate extract of Hedysarum theinum roots. Chem Nat Compd 2007, 43:5-9.
27. Li YZ, Huang J, Guo HC, Ren B: Chemical constituents from Hedysarum polybotrys and their antitumor activities. Chin Trad Herb Drugs 2009, 40:1195-1198.
28. Wang W, Chen HB, Wang WM, Zhao YY: Studies on flavoniod constituents of Hedysarum multijugum . Acta Pharm Sinica 2002, 37:196-198.
29. Wang W, Chen W, Chen HB, Liu JQ, Zhao YY: Study on chemical constituents of Hedysarum multijugum . J Peking University (Health Sciences) 2001, 33:205-208.
30. Yang M, Wang W, Sun JH, Zhao YY, Liang H, Guo DA: Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 2007, 21:3833-3841.
31. Chen SG, Chen JJ, Gao K: Prenylisoflavone derivatives from the roots of Hedysarum scoparium . Chem Pharm Bull 2007, 55:1181-1184.
32. Li YS, Chen JJ, Liao XR, Wang HY, Luo SD: Studies on chemical constituents of Hedysarum sikkimense var Rigidum. Chin Trad Herb Drugs 2001, 32:489-490.
33. Nechepurenko IV, Komarova NI, Kuzovkina IN, Vdovitchenko MY, Polovinka MP, Salakhutdinov NF: Structure of oligomeric proanthocyanidines from Hedysarum thienum roots studied by thiolysis and MALDI-TOF MS. Chem Nat Compd 2009, 45:420-421.
34. Liu Y, Zhao YY, Chen HB, Zhang QY: Isolation and structural elucidation of an unstable isoflavonoid glycoside malonate from radix hedysari. J Chin Pharm Sci 2010, 19:100-103.
35. Chen SG, Li Y, Zhao J, Gao K: Three new prenylfuranoisoflavonoids from the roots of Hedysarum scoparium . Chin J Chem 2008, 26:531-535.
36. Liu Y, Chen HB, Qiao L, Zhao YY: Two new isoprenyl chalcones from Hedysarum gmelinii . J Asian Nat Prod Res 2005, 7:723-727.
37. Rybachenko AI, Kvivut BA, Georgievkii VP: Fluorodensitometric determination of mangiferin and isomangiferin in Hedysarum flavescens and H. Alpinum. Chem Nat Compd 1967, 12:395-396.
38. Denisova OA, Glyzin VI, Rusakova SV, Pimenov MG: Xanthone C-glycosides of Hedysarum denticulatum . Chem Nat Compd 1977, 13:245.
39. Glyzin VI, Ban'kovsii AI, Pimenov MG, Boryaev KI: Xanthone glycosides of Hedysarum flavescens . Chem Nat Compd 1973, 9:409-410.
40. Liu Y, Hai LQ, Zhao YY, Zhang QY: Studies on the chemical constituents of Hedysarum semenovii . China Pharm 2008, 22:568-569.
41. Wang W, An DG, Chen HB, Tu GZ, Zhao YY: Two new pterocarpenes from Hedysarum multijugum . J Asian Nat Prod Res 2003, 5:31-34.
42. Miyase T, Fukushima S, Akiyama Y: Studies on the constituents of Hedysarum polybotrys Hand-Mazz. Chem Pharm Bull 1984, 32:3267-3270.
43. Tian HY, Liu QG: A study on the chemical constituents of Hedysarum Taipeicum (Hand-Mazz) K T Fu. J Southwest Nationalities Collge Nat Sci 1996, 22:182-184.
44. Liu Y, Ma XX, Chen HB, Tu GZ, He JM, Zhao YY: Chemical constituents of Hedysarum gmelinii . J Chin Pharm Sci 2005, 14:75-78.
45. Hai LQ, Zhang QY, Wang Y, Zhao YY: Study on chemical constituents of Hedysarum polybotrys (IV). Lishizhen Med Materia Medica Res 2006, 17:1659.
46. Liu Y, Zhang QY, Chen HB, Wang B, An DG, Zhao YY: Structural determination of saponins from Hedysarum polybotrys . Magn Reson Chem 2006, 44:1128-1130.
47. Wang W, Hai LQ, Zhao YY, Chen HB, Wang B, Liang H: Saponins from roots of Hedysarum multijugum . China J Chin Mat Med 2007, 32:315-317.
48. Liu Y, Zhao YY, Chen HB, Wang B, Zhang QY: Structure elucidation and complete NMR spectral assignment of two triterpenoid saponins from Radix Hedysari. Fitoterapia 2009, 80:127-129.
49. Wang W, Zhao YY, Liang H, Jia Q, Chen HB: Coumestans from Hedysarum multijugum . J Nat Prod 2006, 69:876-880.
50. Neretina OV, Gromova AS, Lutskii VI, Semenov AA, Ushakov IA, Dmitrenok PS, Oven NL: Isolariciresinol glucoside, berberine, and phenolic acid from the aerial part of Hedysarum setigerum . Chem Nat Compd 2004, 40:609-610.
51. Hui HP, Feng SL, Zhao LG, Shi YK, Liu XH: Purification and structure identification of HPS. LiShizhen Med Materia Medica Res 2010, 21:2302-2303.
52. Wang W, Zhao YY, Wang B, Liang H, Tu GZ, Chen HB: Two new arylbenzofurans from the roots of Hedysarum multijugum . J Asian Nat Prod Res 2007, 9:19-22.
53. Zou K, Katsuko K, Zhu S: A novel compound from Hedysarum polybotrys . J Asian Nat Prod Res 2007, 9:699-703.
54. Cheng F, Zou K, Zhu S, Katsuko K: A new phenylpropionate derivative from the rhizomes of Hedysarum polybotrys . Chi J Nat Med 2009, 7:351-353.
55. Kukushkina TA, Vysochina GI, Karnaukhova NA, Selyutina IY: Content of mangiferin and total amount of xanthones in plants of some wild-growing and introduced Hedysarum (Fabaceae) species. Rastitel'nye Resursy 2011, 47:99-106.
56. Ma D, Feng SL, Zhao LG, Liu XH, Li B, Li XD, Hu FD: Purification of the radix Hedysari polysaccharide and determination of its constitution. Chin JAMP 2008, 25:177-179.
57. Hikino H, Funayama S, Endo K: Hypotensive principle of astragalus and Hedysarum roots. Planta Med 1976, 30:297-302.
58. Shi YK, Zhao LG, Liu XH, Hu FD, Cui F, Bi YY, Ma YF, Feng SL: Structural characterization of a sulfated glucan isolated from the aqueous extract of Hedysarum polybotrys Hand.-Mazz. Carbohydr Polym 2012, 87:160-169.
59. Tibe O, Meagher LP, Fraser K, Harding DRK: Condensed Tannins and Flavonoids from the Forage Legume Sulla (Hedysarum coronarium). J Agr Food Chem 2011, 59:9402-9409.
60. Hui HP, Feng SL, Hu FD, Cui F, Wu YQ: Study on antioxidative activity of polysaccharide from Radix Hedysari in vitro . J Anhui Agri Sci 2010, 38:4056-4057.
61. Qiu T, Bai J, Jiang Y, Huang ZL: The effect of HPS on RNA and DNA content in several organs of mice. Chin Trad Pat Med 1992, 14:33-34.
62. Zhang JP, Guo LP, Ruan SY: The effect of HPS on LPO and SOD content in SMC of rabbits. J Gansu College of Trad Chin Med 1992, 9:3.
63. Hai LQ, Kang JS, Sun L: Effects of aqueous extract of Hedysarum austrosibiricum on metabolism of oxyen free radicals in subacute aging mice caused by D-galactose. China J Chin Materia Medica 2007, 32:729-731.
64. Mao XJ, Wang JZ, Wang FL: Effects of radix hedysari polysaccharide (RHPS) & astragali polysaccharide (APS) on immune functions. Chin Pharm Bull 1989, 5:367-372.
65. Quan JX: The pharmacological research on Hedysari . LiShizhen Med Materia Medica Res 1997, 8:178-180.
66. Wang W, You CG, Wang Y, Wang CM, Hu JC, Zheng HJ: The RHTS' enhancement to the function of mouse immunocytes and its relation with CaM levels in the cells. J Lanzhou University 2000, 5:112-116.
67. Yu L, Cao Y, Wei X, Xu L, Fang TH: The Immuno regulation effects of different extracts from radix Astragali and radix Hedysari. J Anhui Agri Sci 2010, 38:20623-20624.
68. Wei DF, Zhang LF, Cheng WD, Gui MM, Li XY, Wei YX, Bao YC: Comparative study of Hedysari Radix and Astragali Radix alternative classic tonification prescriptions on humoral immunity in immunosuppressed mice. Zhongyaocai 2012, 35:944-948.
69. Li SG, Wang DG, Tian W, Wang XX, Zhao JX, Liu Z, Chen R: Characterization and anti-tumor activity of a polysaccharide from Hedysarum polybotrys Hand.-Mazz. Carbohydr Polym 2008, 73:344-350.
70. Hu FD, Li XD, Zhao LG, Feng SL, Wang CM: Antidiabetic properties of purified polysaccharide from Hedysarum polybotrys . Can J Physiol Pharm 2010, 88:64-72.
71. Wei SY, Zhang PX, Han N, Dang Y, Zhang HB, Zhang DY, Fu ZG, Jiang BG: Effects of Hedysari polysaccharides on regeneration and function recovery following peripheral nerve injury in rats. The American J Chin Med 2009, 37:57-67.
72. Huang ZL, Cui ZM, Ren Y, Zhang J: Pharmacological effects on HPS complexes. J Gansu College of Trad Chin Med 1987, 3:40-43.