HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activity

Kidney and Blood Pressure Research

Volumn 37, Issue 4-5, 2013, Pages 229-239

  Kee, Hae Jin ^a   Bae, Eun Hui ^b   Park, Sangha ^a   Lee, Ko Eun ^b   Suh, Sang Heon ^b   Kim, Soo Wan ^b   Jeong, Myung Ho ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

Cardiac hypertrophy; DOCA salt hypertensive rats; GATA6; HDAC enzyme activity; Histone deacetylase inhibitor

Indexed keywords

HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; TRANSCRIPTION FACTOR GATA 6; VALPROIC ACID; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE 9; TRANSCRIPTION FACTOR GATA 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HEART LEFT VENTRICLE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL CELL; ANIMAL TISSUE; BODY WEIGHT; DEOXYCORTICOSTERONE-SALT INDUCED HYPERTENSION; HEART MUSCLE CELL; HEART PROTECTION; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CARDIOMEGALY; DESOXYCORTICOSTERONE ACETATE; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FIBROSIS; HISTONE DEACETYLASES; HYPERTENSION; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; VALPROIC ACID;

EID: 84880183268     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000350148     Document Type: Article

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