Pulmonary toxicity screening of triclosan in rats after intratracheal instillation

Journal of Toxicological Sciences

Volumn 38, Issue 3, 2013, Pages 471-475

  Kwon, Jung Taek ^a   Yang, Young Su ^b   Kang, Min Sung ^b   Seo, Gyun Baek ^a   Lee, Dong Hun ^b   Yang, Mi Jin ^b   Shim, Ilseob ^a   Kim, Hyun Mi ^a   Kim, Pilje ^a   Choi, Kyunghee ^a   Lee, Kyuhong ^a  

^a National Institute of Environmental Research   (South Korea)

^b Korea Institute of Toxicology   (South Korea)

Author keywords

Acute lung injury; Lung permeability; Triclosan

Indexed keywords

3 (4, 5 DIMETHYL 2 THIAZOLYL) 2, 5 DIPHENYLTETRAZOLIUM BROMIDE; INTERLEUKIN 6; LACTATE DEHYDROGENASE; PROTEIN; TRICLOSAN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL COUNT; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HISTOPATHOLOGY; INFLAMMATION; LETTER; LUNG LAVAGE; LUNG TOXICITY; MALE; NEUTROPHIL; NONHUMAN; RAT; TOXICITY TESTING;

EID: 84880168986     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.38.471     Document Type: Letter

References (11)

1. Abraham, E. (2003): Neutrophils and acute lung injury. Crit. Care Med., 31, S195-S199.
2. Adolfsson-Erici, M., Pettersson, M., Parkkonen, J. and Sturve, J. (2002): Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden. Chemosphere, 46, 1485-1489.
3. Calafat, A.M., Ye, X., Wong, L.Y., Reidy, J.A. and Needham, L.L. (2008): Urinary concentrations of triclosan in the U.S. population: 2003-2004. Environ. Health. Perspect., 116, 303-307.
4. Heath, R.J., Rubin, J.R., Holland, D.R., Zhang, E., Snow, M.E. and Rock, C.O. (1999): Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J. Biol. Chem., 274, 11110-11114.
5. Jones, R.D., Jampani, H.B., Newman, J.L. and Lee, A.S. (2000): Triclosan: a review of effectiveness and safety in health care settings. Am. J. Infect. Control., 28, 184-196.
6. Kumar, V. and Sharma, A. (2010): Neutrophils: Cinderella of innate immune system. Int. Immunopharmacol., 10, 1325-1334.
7. Leutkemeier, H., Ullmann, L., Zak, F., Sachsse, K. and Shess, R. (1974): Irgasan DP 300 (FAT 80023/A) 21-day inhalation study on the rat. Ciba-Geigy Limited.
8. Ohnuma, A., Yoshida, T., Horiuchi, H., Fukumori, J., Tomita, M., Kojima, S., Takahashi, N., Fukuyama, T., Hayashi, K. and Yamaguchi, S. (2011): Altered pulmonary defense system in lung injury induced by didecyldimethylammonium chloride in mice. Inhal. Toxicol., 23, 476-485.
9. Ohnuma, A., Yoshida, T., Tajima, H., Fukuyama, T., Hayashi, K., Yamaguchi, S., Ohtsuka, R., Sasaki, J., Fukumori, J. and Tomita, M. (2010): Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice. Exp. Toxicol. Pathol., 62, 643-651.
10. Ware, L.B. (2006): Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin. Respir. Crit. Care Med., 27, 337-349.
11. Warheit, D.B., Carakostas, M.C., Hartsky, M.A. and Hansen, J.F. (1991): Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: Comparisons of pulmonary responses to carbonyl iron and silica. Toxicol. Appl. Pharmacol., 107, 350-368.