Dermcidin: What is its antibiotic potential?

Future Microbiology

Volumn 8, Issue 7, 2013, Pages 817-819

  Zeth, Kornelius ^a,b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

antimicrobial peptide; crystal structure; dermcidin; human skin; superbugs

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DERMCIDIN; PROTEINASE;

CELL MEMBRANE; EVOLUTIONARY ADAPTATION; HOST RESISTANCE; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; REVIEW; RIBOSOME; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; DRUG RESISTANCE, BACTERIAL; HUMANS; PEPTIDES;

EID: 84880130944     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.13.67     Document Type: Review

References (13)

1. Bush K, Courvalin P, Dantas G et al. Tackling antibiotic resistance. Nat. Rev. Microbiol. 9(12), 894-896 (2011).
2. Hersh AL, Chambers HF, Maselli JH, Gonzales R. National trends in ambulatory visits and antibiotic prescribing for skin and soft-tissue infections. Arch. Intern. Med. 168(14), 1585-1591 (2008).
3. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 415, 389-395 (2002).
4. Hancock RE, Diamond G. The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol. 8, 402-410 (2000).
5. Yonath A. Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation. Annu. Rev. Biochem. 74, 649-679 (2005).
6. Fox JL. Antimicrobial peptides stage a comeback. Nat. Biotechnol. 31, 379-382 (2013).
7. Fjell CD, Hiss JA, Hancock REW, Schneider G. Designing antimicrobial peptides: form follows function. Nat. Rev. Drug Discov. 11, 37-51 (2012).
8. Hancock REW, Sahl HG. Antimicrobial and host-defense peptides as new antiinfective therapeutic strategies. Nat. Biotechnol. 24, 1551-1557 (2006).
9. Vandamme D, Landuyt B, Luyten W, Schoofs L. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol. 280, 22-35 (2012).
10. Schittek B, Hipfel R, Sauer B et al. Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat. Immunol. 2, 1133-1137 (2001).
11. Song C, Weichbrodt C, Salnikov ES et al. Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proc. Natl Acad. Sci. USA 110, 4586-4591 (2013).
12. Stevenson CL. Advances in peptide pharmaceuticals. Curr. Pharm. Biotechnol. 10, 122-137 (2009).
13. Blanes-Mira C, Clemente J, Jodas G et al. A synthetic hexapeptide (argireline) with antiwrinkle activity. Int. J. Cosmet. Sci. 24, 303-310 (2002).